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Article

Identification of Intercellular Crosstalk between Decidual Cells and Niche Cells in Mice

Guangdong Laboratory for Lingnan Modern Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
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Author to whom correspondence should be addressed.
Academic Editor: Satoshi Kishigami
Int. J. Mol. Sci. 2021, 22(14), 7696; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147696
Received: 23 June 2021 / Revised: 15 July 2021 / Accepted: 16 July 2021 / Published: 19 July 2021
(This article belongs to the Special Issue Cytogenomics)
Decidualization is a crucial step for human reproduction, which is a prerequisite for embryo implantation, placentation and pregnancy maintenance. Despite rapid advances over recent years, the molecular mechanism underlying decidualization remains poorly understood. Here, we used the mouse as an animal model and generated a single-cell transcriptomic atlas of a mouse uterus during decidualization. By analyzing the undecidualized inter-implantation site of the uterus as a control, we were able to identify global gene expression changes associated with decidualization in each cell type. Additionally, we identified intercellular crosstalk between decidual cells and niche cells, including immune cells, endothelial cells and trophoblast cells. Our data provide a valuable resource for deciphering the molecular mechanism underlying decidualization. View Full-Text
Keywords: decidualization; mouse; single-cell RNA-seq; transcriptional changes decidualization; mouse; single-cell RNA-seq; transcriptional changes
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MDPI and ACS Style

He, J.-P.; Tian, Q.; Zhu, Q.-Y.; Liu, J.-L. Identification of Intercellular Crosstalk between Decidual Cells and Niche Cells in Mice. Int. J. Mol. Sci. 2021, 22, 7696. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147696

AMA Style

He J-P, Tian Q, Zhu Q-Y, Liu J-L. Identification of Intercellular Crosstalk between Decidual Cells and Niche Cells in Mice. International Journal of Molecular Sciences. 2021; 22(14):7696. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147696

Chicago/Turabian Style

He, Jia-Peng, Qing Tian, Qiu-Yang Zhu, and Ji-Long Liu. 2021. "Identification of Intercellular Crosstalk between Decidual Cells and Niche Cells in Mice" International Journal of Molecular Sciences 22, no. 14: 7696. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147696

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