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Review

Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation

1
Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, 41092 Seville, Spain
2
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28029 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Ivan Y. Iourov
Int. J. Mol. Sci. 2021, 22(14), 7281; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147281
Received: 23 June 2021 / Revised: 2 July 2021 / Accepted: 4 July 2021 / Published: 6 July 2021
(This article belongs to the Special Issue Cytogenomics)
The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects, regulates, and organizes the eukaryote genome and adapts to epigenetic changes and to its environment. The NE morphology is characterized by a wide range of diversity and abnormality such as invagination and blebbing, and it is a diagnostic factor for pathologies such as cancer. Recently, the micronuclei, a small nucleus that contains a full chromosome or a fragment thereof, has gained much attention. The NE of micronuclei is prone to collapse, leading to DNA release into the cytoplasm with consequences ranging from the activation of the cGAS/STING pathway, an innate immune response, to the creation of chromosomal instability. The discovery of those mechanisms has revolutionized the understanding of some inflammation-related diseases and the origin of complex chromosomal rearrangements, as observed during the initiation of tumorigenesis. Herein, we will highlight the complexity of the NE biology and discuss the clinical symptoms observed in NE-related diseases. The interplay between innate immunity, genomic instability, and nuclear envelope leakage could be a major focus in future years to explain a wide range of diseases and could lead to new classes of therapeutics. View Full-Text
Keywords: nuclear envelope; nuclear envelope disruption; inflammation; cGAS/STING; chromosomal instability; envelopathy; cancer; lipodystrophy; neuropathy nuclear envelope; nuclear envelope disruption; inflammation; cGAS/STING; chromosomal instability; envelopathy; cancer; lipodystrophy; neuropathy
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MDPI and ACS Style

Gauthier, B.R.; Comaills, V. Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation. Int. J. Mol. Sci. 2021, 22, 7281. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147281

AMA Style

Gauthier BR, Comaills V. Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation. International Journal of Molecular Sciences. 2021; 22(14):7281. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147281

Chicago/Turabian Style

Gauthier, Benoit R., and Valentine Comaills. 2021. "Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation" International Journal of Molecular Sciences 22, no. 14: 7281. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147281

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