Next Article in Journal
Extracellular Vesicles and Thrombosis: Update on the Clinical and Experimental Evidence
Previous Article in Journal
NOP53 Suppresses Autophagy through ZKSCAN3-Dependent and -Independent Pathways
Review

Characteristics of TIMP1, CD63, and β1-Integrin and the Functional Impact of Their Interaction in Cancer

Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo 669, 5 Floor, São Paulo 04039-032, Brazil
*
Author to whom correspondence should be addressed.
Academic Editors: Karel Smetana and Michal Kolář
Int. J. Mol. Sci. 2021, 22(17), 9319; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179319
Received: 2 July 2021 / Revised: 10 August 2021 / Accepted: 13 August 2021 / Published: 27 August 2021
(This article belongs to the Special Issue Molecular Signal Transduction in Tumor Progression and Metastasis)
Tissue Inhibitor of Metalloproteases 1, also known as TIMP-1, is named for its well-established function of inhibiting the proteolytic activity of matrix metalloproteases. Given this function, many studies were carried out to verify if TIMP-1 was able to interrupt processes such as tumor cell invasion and metastasis. In contrast, many studies have shown that TIMP-1 expression is increased in several types of tumors, and this increase was correlated with a poor prognosis and lower survival in cancer patients. Later, it was shown that TIMP-1 is also able to modulate cell behavior through the induction of signaling pathways involved in cell growth, proliferation, and survival. The mechanisms involved in the regulation of the pleiotropic functions of TIMP-1 are still poorly understood. Thus, this review aimed to present literature data that show its ability to form a membrane complex with CD63 and β1-integrin, and point to N-glycosylation as a potential regulatory mechanism of the functions exerted by TIMP-1. This article reviewed the characteristics and functions performed individually by TIMP1, CD63, and β1-integrin, the roles of the TIMP-1/CD63/β1-integrin complex, both in a physiological context and in cancer, and the regulatory mechanisms involved in its assembly. View Full-Text
Keywords: TIMP-1; cancer; N-glycosylation; CD63; β1-integrin TIMP-1; cancer; N-glycosylation; CD63; β1-integrin
Show Figures

Figure 1

MDPI and ACS Style

Justo, B.L.; Jasiulionis, M.G. Characteristics of TIMP1, CD63, and β1-Integrin and the Functional Impact of Their Interaction in Cancer. Int. J. Mol. Sci. 2021, 22, 9319. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179319

AMA Style

Justo BL, Jasiulionis MG. Characteristics of TIMP1, CD63, and β1-Integrin and the Functional Impact of Their Interaction in Cancer. International Journal of Molecular Sciences. 2021; 22(17):9319. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179319

Chicago/Turabian Style

Justo, Beatriz L., and Miriam G. Jasiulionis 2021. "Characteristics of TIMP1, CD63, and β1-Integrin and the Functional Impact of Their Interaction in Cancer" International Journal of Molecular Sciences 22, no. 17: 9319. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179319

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop