ijms-logo

Journal Browser

Journal Browser

Special Issue "Molecular Signal Transduction in Tumor Progression and Metastasis"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Prof. Dr. Karel Smetana, Jr.
E-Mail Website1 Website2 Website3
Guest Editor
1st Faculty Medicine, Institute of Anatomy and BIOCEV, Charles University, Prague 2 and Vestec, Prague, Czech Republic
Interests: tumor microenvironment; cutaneous malignant melanoma; cancer-associated fibroblasts; squamous epithelium; stem cells
Special Issues, Collections and Topics in MDPI journals
Prof. Michal Kolář
E-Mail Website
Guest Editor
Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
Interests: tumor microenvironment; cancer transcriptomics; genomics; bioinformatics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Even in this COVID-19 era, cancer represents one of the most relevant medical, social, and economic issues. The epidemic-like occurrence of malignant diseases is associated with many reasons; however, the aging of the population remains one of the main causes. Despite the progress in diagnostics and therapy represented by biological and targeted treatments, new approaches are required that are suitable for elderly and frail patients. One possibility is therapeutic intervention in the signaling network formed between the cancer and non-cancer cells in the tumor microenvironment. This option includes targeting the interactions that maintain stem cell properties of cancer stem cells. Another possibility is the modulation of ligand–receptor interactions and signal transduction in the cells within the cancer ecosystem. Detailed knowledge of this signaling network is necessary, not only to understand the mechanisms of cancer progression and metastasis but also to develop new targeted therapeutic modalities.

Topics of this Special Issue include but are not limited to:

  • Cancer progression and metastasis;
  • Targeted therapy of cancer;
  • Cancer microenvironment;
  • Cancer-associated fibroblasts;
  • Tumor-associated macrophages;
  • Immune cells in cancer ecosystem;
  • Cancer stem cells;
  • Extracellular matrix and cancer;
  • Signal transduction in cancer cells;
  • Receptor modulators.

Prof. Dr. Karel Smetana, Jr.
Prof. Michal Kolář
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cancer progression and metastasis
  • Targeted therapy of cancer
  • Cancer microenvironment
  • Cancer-associated fibroblasts
  • Tumor-associated macrophages
  • Immune cells in cancer ecosystem
  • Cancer stem cells
  • Extracellular matrix and cancer
  • Signal transduction in cancer cell
  • Receptor modulators

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Review
Characteristics of TIMP1, CD63, and β1-Integrin and the Functional Impact of Their Interaction in Cancer
Int. J. Mol. Sci. 2021, 22(17), 9319; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179319 - 27 Aug 2021
Viewed by 736
Abstract
Tissue Inhibitor of Metalloproteases 1, also known as TIMP-1, is named for its well-established function of inhibiting the proteolytic activity of matrix metalloproteases. Given this function, many studies were carried out to verify if TIMP-1 was able to interrupt processes such as tumor [...] Read more.
Tissue Inhibitor of Metalloproteases 1, also known as TIMP-1, is named for its well-established function of inhibiting the proteolytic activity of matrix metalloproteases. Given this function, many studies were carried out to verify if TIMP-1 was able to interrupt processes such as tumor cell invasion and metastasis. In contrast, many studies have shown that TIMP-1 expression is increased in several types of tumors, and this increase was correlated with a poor prognosis and lower survival in cancer patients. Later, it was shown that TIMP-1 is also able to modulate cell behavior through the induction of signaling pathways involved in cell growth, proliferation, and survival. The mechanisms involved in the regulation of the pleiotropic functions of TIMP-1 are still poorly understood. Thus, this review aimed to present literature data that show its ability to form a membrane complex with CD63 and β1-integrin, and point to N-glycosylation as a potential regulatory mechanism of the functions exerted by TIMP-1. This article reviewed the characteristics and functions performed individually by TIMP1, CD63, and β1-integrin, the roles of the TIMP-1/CD63/β1-integrin complex, both in a physiological context and in cancer, and the regulatory mechanisms involved in its assembly. Full article
(This article belongs to the Special Issue Molecular Signal Transduction in Tumor Progression and Metastasis)
Show Figures

Figure 1

Back to TopTop