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Review

Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei 230032, China
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Academic Editor: Hidayat Hussain
Int. J. Mol. Sci. 2021, 22(19), 10827; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910827
Received: 18 September 2021 / Revised: 5 October 2021 / Accepted: 5 October 2021 / Published: 7 October 2021

Lung cancer is one of the most prevalent malignancies worldwide. Despite the undeniable progress in lung cancer research made over the past decade, it is still the leading cause of cancer-related deaths and continues to challenge scientists and researchers engaged in searching for therapeutics and drugs. The tumor microenvironment (TME) is recognized as one of the major hallmarks of epithelial cancers, including the majority of lung cancers, and is associated with tumorigenesis, progression, invasion, and metastasis. Targeting of the TME has received increasing attention in recent years. Natural products have historically made substantial contributions to pharmacotherapy, especially for cancer. In this review, we emphasize the role of the TME and summarize the experimental proof demonstrating the antitumor effects and underlying mechanisms of natural products that target the TME. We also review the effects of natural products used in combination with anticancer agents. Moreover, we highlight nanotechnology and other materials used to enhance the effects of natural products. Overall, our hope is that this review of these natural products will encourage more thoughts and ideas on therapeutic development to benefit lung cancer patients. View Full-Text
Keywords: natural products; tumor microenvironment (TME); lung cancer; phytochemicals; botanical agents natural products; tumor microenvironment (TME); lung cancer; phytochemicals; botanical agents
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MDPI and ACS Style

Yang, Y.; Li, N.; Wang, T.-M.; Di, L. Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment. Int. J. Mol. Sci. 2021, 22, 10827. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910827

AMA Style

Yang Y, Li N, Wang T-M, Di L. Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment. International Journal of Molecular Sciences. 2021; 22(19):10827. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910827

Chicago/Turabian Style

Yang, Yue, Ning Li, Tian-Ming Wang, and Lei Di. 2021. "Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment" International Journal of Molecular Sciences 22, no. 19: 10827. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910827

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