Next Article in Journal
A Proline-Based Tectons and Supramolecular Synthons for Drug Design 2.0: A Case Study of ACEI
Next Article in Special Issue
Comparison of Five Oral Cannabidiol Preparations in Adult Humans: Pharmacokinetics, Body Composition, and Heart Rate Variability
Previous Article in Journal
Oral Treatment of Central Serous Chorioretinopathy Patients Using Propranolol Tablets
Previous Article in Special Issue
Towards Better Delivery of Cannabidiol (CBD)
Due to scheduled maintenance work on our core network, there may be short service disruptions on this website between 16:00 and 16:30 CEST on September 25th.
Article

Topical Administration of Cannabidiol: Influence of Vehicle-Related Aspects on Skin Permeation Process

Department of Pharmaceutical Sciences, Università degli Studi di Milano, via Mangiagalli 25, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(11), 337; https://0-doi-org.brum.beds.ac.uk/10.3390/ph13110337
Received: 23 September 2020 / Revised: 19 October 2020 / Accepted: 21 October 2020 / Published: 23 October 2020
Cannabidiol (CBD) is a non-psychoactive cannabinoid isolated from Cannabis sativa which, given its claimed beneficial properties and therapeutic potential, has lately aroused considerable attention from the scientific community. Starting from the little literature evidence, the main purpose of this study was to investigate the topical administration of CBD, with particular focus on the influence of vehicle-related aspects on the skin permeation process. This could provide useful information for the design of suitable drug delivery systems which could be used in developing topical medicines and cosmetics. In vitro human skin permeation studies were conducted using modified Franz diffusion cells to compare the performance of four solutions and two semisolid formulations. The Hildebrand solubility parameter was used to better understand the thermodynamic aspects implied in the partitioning process of the cannabinoid compound into the skin. It was interestingly found that a hydrophilic gel, mostly consisting of propylene glycol (79%, w/w), can be an optimal choice for the topical administration of CBD. Moreover, the feasibility of the preparation of CBD-loaded (trans)dermal patches, made with new printing technology, was also demonstrated. View Full-Text
Keywords: cannabidiol; topical administration; in vitro permeation; human skin; solutions; semisolid dosage forms; (trans)dermal patch; Hildebrand solubility parameter cannabidiol; topical administration; in vitro permeation; human skin; solutions; semisolid dosage forms; (trans)dermal patch; Hildebrand solubility parameter
Show Figures

Graphical abstract

MDPI and ACS Style

Casiraghi, A.; Musazzi, U.M.; Centin, G.; Franzè, S.; Minghetti, P. Topical Administration of Cannabidiol: Influence of Vehicle-Related Aspects on Skin Permeation Process. Pharmaceuticals 2020, 13, 337. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13110337

AMA Style

Casiraghi A, Musazzi UM, Centin G, Franzè S, Minghetti P. Topical Administration of Cannabidiol: Influence of Vehicle-Related Aspects on Skin Permeation Process. Pharmaceuticals. 2020; 13(11):337. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13110337

Chicago/Turabian Style

Casiraghi, Antonella, Umberto M. Musazzi, Giorgio Centin, Silvia Franzè, and Paola Minghetti. 2020. "Topical Administration of Cannabidiol: Influence of Vehicle-Related Aspects on Skin Permeation Process" Pharmaceuticals 13, no. 11: 337. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13110337

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop