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Fetuin-A and Fetuin-B in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis and Meta-Regression

1
Xiangya School of Public Health, Central South University, Changsha 410008, China
2
Department of Mathematics and Statistics, Mzuzu University, Mzuzu 999120, Malawi
3
Saw Swee Hock School of Public Health, National University of Singapore, Singapore 999002, Singapore
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(8), 2735; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17082735
Received: 25 February 2020 / Revised: 8 April 2020 / Accepted: 9 April 2020 / Published: 15 April 2020
The magnitude of the effect of fetuin-A and fetuin-B on non-alcoholic fatty liver disease (NAFLD) remains undefined. Therefore, the aim of this study was to synthesize previous findings to obtain a reliable estimation of this relationship. This study was registered in PROSPERO with the number CRD42019126314. Studies published not later than March 2019, examining the relationship between fetuin-A, fetuin-B, and NAFLD, were identified by a systematic search in the electronic databases of the Web of Science, PubMed, Embase, and Cochrane Library. Pooled estimates of standardized mean difference (SMD), calculated using the random-effects model in a meta-analysis, were applied to estimate the strength of the association between fetuin-A, fetuin-B, and NAFLD. Thirty publications were identified and analyzed based on specified inclusion criteria. Collectively, they consisted of 3800 NAFLD participants and 3614 controls. Compared with the controls, significant higher values of the fetuin-A (SMD = 0.83, 95% CI: 0.59 to 1.07, Z = 6.82, p < 0.001) and fetuin-B (SMD = 0.18, 95% CI: 0.02 to 0.33, Z = 2.27, p = 0.023) were observed in NAFLD patients. Meanwhile, in the subgroup analysis, the effect value of fetuin-A in the NASH group was significantly higher than that in the NAFL group (p = 0.036). The findings of this study suggest that elevated fetuin-A and fetuin-B may independently indicate the occurrence of NAFLD. Nevertheless, further research is needed to confirm these results. View Full-Text
Keywords: fetuin-A; fetuin-B; non-alcoholic fatty liver disease; meta-analysis; meta-regression fetuin-A; fetuin-B; non-alcoholic fatty liver disease; meta-analysis; meta-regression
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MDPI and ACS Style

Pan, X.; Kaminga, A.C.; Chen, J.; Luo, M.; Luo, J. Fetuin-A and Fetuin-B in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis and Meta-Regression. Int. J. Environ. Res. Public Health 2020, 17, 2735. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17082735

AMA Style

Pan X, Kaminga AC, Chen J, Luo M, Luo J. Fetuin-A and Fetuin-B in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis and Meta-Regression. International Journal of Environmental Research and Public Health. 2020; 17(8):2735. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17082735

Chicago/Turabian Style

Pan, Xiongfeng, Atipatsa C. Kaminga, Jihua Chen, Miyang Luo, and Jiayou Luo. 2020. "Fetuin-A and Fetuin-B in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis and Meta-Regression" International Journal of Environmental Research and Public Health 17, no. 8: 2735. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17082735

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