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Review

Persistent Detection and Infectious Potential of SARS-CoV-2 Virus in Clinical Specimens from COVID-19 Patients

Veterans Affairs Medical Center, Martinsburg, WV 25405, USA
Academic Editors: Mary Kearney and Bill Sugden
Received: 6 November 2020 / Revised: 26 November 2020 / Accepted: 1 December 2020 / Published: 3 December 2020
(This article belongs to the Special Issue Mechanisms of Viral Persistence)
The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) that emerged in December 2019 as the causative agent of Coronavirus 2019 (COVID-19) and was declared a pandemic by the World Health Organization in March 2020 has several distinctive features, including extensive multiorgan involvement with a robust systemic inflammatory response, significant associated morbidity and mortality, and prolonged persistence of viral RNA in the clinical specimens of infected individuals as detected by Reverse Transcription Polymerase Chain Reaction (RT-PCR) amplification. This review begins with an overview of SARS-CoV-2 morphology and replication and summarizes what is known to date about the detection of the virus in nasal, oropharyngeal, and fecal specimens of patients who have recovered from COVID-19, with a focus on the factors thought to contribute to prolonged detection. This review also provides a discussion on the infective potential of this material from asymptomatic, pre-symptomatic, and convalescing individuals, to include a discussion of the relative persistence and infectious potential of virus in clinical specimens recovered from pediatric COVID-19 patients. View Full-Text
Keywords: coronavirus; SARS-CoV-2; COVID-19; shedding coronavirus; SARS-CoV-2; COVID-19; shedding
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MDPI and ACS Style

Zapor, M. Persistent Detection and Infectious Potential of SARS-CoV-2 Virus in Clinical Specimens from COVID-19 Patients. Viruses 2020, 12, 1384. https://0-doi-org.brum.beds.ac.uk/10.3390/v12121384

AMA Style

Zapor M. Persistent Detection and Infectious Potential of SARS-CoV-2 Virus in Clinical Specimens from COVID-19 Patients. Viruses. 2020; 12(12):1384. https://0-doi-org.brum.beds.ac.uk/10.3390/v12121384

Chicago/Turabian Style

Zapor, Michael. 2020. "Persistent Detection and Infectious Potential of SARS-CoV-2 Virus in Clinical Specimens from COVID-19 Patients" Viruses 12, no. 12: 1384. https://0-doi-org.brum.beds.ac.uk/10.3390/v12121384

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