Persistent Detection and Infectious Potential of SARS-CoV-2 Virus in Clinical Specimens from COVID-19 Patients
Abstract
:1. Introduction
2. SARS-CoV-2 Entry and Replication
3. Duration of SARS-CoV-2 RT-PCR Positivity and Factors Associated with Prolonged Clinical Shedding
4. Persistent Detection of SARS-CoV-2 in Feces
5. Persistent Detection of SARS-CoV-2 in Other Bodily Fluids
6. Infectious Potential of Clinically Shed SARS-CoV-2
7. Infectivity of SARS-CoV-2 Shed by Pre-Symptomatic and Asymptomatic Infected Individuals
8. SARS-CoV-2 Clinical Shedding by Children
9. Persistent Clinical Shedding, Relapse, and Reinfection
10. Discussion
Funding
Acknowledgments
Conflicts of Interest
References
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Study (Reference) | Number Studied (N) | Median Duration in Respiratory Specimens (Days) | Independent Factors Associated with Viral Persistence |
---|---|---|---|
Zhou F, Yu T, Du R, et al. [32] | 191 | 20.0 days (IQR 17.0–24.0) | NE |
Zhou B, She J, Wang Y, Ma X. [33] | 41 | 31 (IQR 24.0–40.0) | NE |
Xiao AT, Tong YX, Zhang S. [40] | 56 | 24 (IQR, 18–31) | NE |
Zheng S, Fan J, Yu F, et al. [34] | 96 | 18 (Range 13–29) | (1) severe disease (21 days, 14–30 days) |
(2) age > 60 years | |||
(3) male gender | |||
Fang Z, Zhang Y, Hang C, Ai J, Li S, Zhang W. [35] | 32 | 22.25 ± 3.62 (ICU) vs. 15.67 ± 6.68 (non-ICU) | ICU hospitalization |
Li TZ, Cao ZH, Chen Y, et al. [39]) | 101 | 11 (IQR 8–14.3) | (1) temperature > 38.5 °C) (OR 5.1, 95%CI: 1.5–18.1) |
(2) corticosteroid use (OR 6.3, 95%CI: 1.5–27.8) | |||
(3) time from onset to hospitalization (OR 1.8, 95%CI: 1.19–2.7) | |||
Kaijin Xu, Yanfei Chen, Jing Yuan, et al. [41] | 113 | 17 (IQR, 13–22) | (1) male gender (OR, 3.24; 95% CI, 1.31–8.02) |
(2) invasive mechanical ventilation (OR, 9.88; 95% CI, 1.11–88.02) | |||
(3) time from illness onset to hospital admission (odds ratio [OR], 1.30; 95% confidence interval [CI], 1.10–1.54; p = 0.002) |
Study (Reference) | Number Studied (N) | Median Age | Median Duration in Respiratory Specimens (Days) | Median Duration in Fecal Specimens (Days) | Median Time to Seropositivity (Days) |
---|---|---|---|---|---|
Bahar B, Jacquot C, Mo YD, et al. [76] | 6369 | 32 (ages 6–15 years) | NE | 18 (36 days for “adequate levels” of neutralizing antibodies) | |
18 (ages 16–22 years) | |||||
Santos VS, Gurgel RQ, Cuevas LE, et al. [52] | 36 | 74 months (mean) | 12 (mean) | 22 (mean) | NE |
56 months (mean) | NE | NE | |||
84 months (mean) | 14.3 (mean) | 16.3 (mean) | |||
91 (mean) | 3.9 (mean) | 18.1 (mean) | |||
Xu CLH, Raval M, Schnall JA, et al. [51] | 69 | 11.1 ± (mean) ± 5.8 | 23.6 ± (mean) ± 8.8 | NE | |
Liu P, Cai J, Jia R, et al. [77] | 9 | 13 (range 6–24) | 43 (range 28–66) | 12.9 | |
De Ioris MA, Scarselli A, Ciofi Degli Atti ML, et al. [78] | 22 | 84 months (range 8 days–210 months) | 8 (range 1–21) | 14 (range 10–15) | NE |
Lu Y, Li Y, Deng W, et al. [79] | 110 | 6 years | 15 (IQR 11–20) | NE | NE |
11 (asymptomatic) | |||||
17 (symptomatic) |
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Zapor, M. Persistent Detection and Infectious Potential of SARS-CoV-2 Virus in Clinical Specimens from COVID-19 Patients. Viruses 2020, 12, 1384. https://0-doi-org.brum.beds.ac.uk/10.3390/v12121384
Zapor M. Persistent Detection and Infectious Potential of SARS-CoV-2 Virus in Clinical Specimens from COVID-19 Patients. Viruses. 2020; 12(12):1384. https://0-doi-org.brum.beds.ac.uk/10.3390/v12121384
Chicago/Turabian StyleZapor, Michael. 2020. "Persistent Detection and Infectious Potential of SARS-CoV-2 Virus in Clinical Specimens from COVID-19 Patients" Viruses 12, no. 12: 1384. https://0-doi-org.brum.beds.ac.uk/10.3390/v12121384