Next Article in Journal
The Emergence of a vv + MDV Can Break through the Protections Provided by the Current Vaccines
Next Article in Special Issue
Viral Genomic Characterization and Replication Pattern of Human Polyomaviruses in Kidney Transplant Recipients
Previous Article in Journal
PA from a Recent H9N2 (G1-Like) Avian Influenza A Virus (AIV) Strain Carrying Lysine 367 Confers Altered Replication Efficiency and Pathogenicity to Contemporaneous H5N1 in Mammalian Systems
Previous Article in Special Issue
Indoleamine 2,3-Dioxygenase Is Involved in Interferon Gamma’s Anti-BKPyV Activity in Renal Cells
Article

Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19

1
Microbiology and Virology Unit, University Hospital City of Health and Science of Turin, Corso Bramante 88, 10126 Turin, Italy
2
Nephrology Unit, University Hospital City of Health and Science of Turin, Corso Bramante 88, 10126 Turin, Italy
3
Pathology Unit, University Hospital City of Health and Science of Turin, Corso Bramante 88, 10126 Turin, Italy
*
Author to whom correspondence should be addressed.
Received: 27 August 2020 / Revised: 16 September 2020 / Accepted: 18 September 2020 / Published: 20 September 2020
(This article belongs to the Special Issue BK Virus and Transplantation)
Background: In kidney transplant patients, polyomavirus-associated nephropathy (PVAN) represents a serious complication; the key factor for the development of PVAN is immunosuppression level and modulation of anti-rejection treatment represents the first line of intervention. Allograft biopsy and histology remain the criterion standard for diagnosing PVAN. Methods: All consecutive renal biopsies with the diagnosis of PVAN carried out at the University Hospital City of Health and Science of Turin over a five-years period were studied. Renal allograft biopsy was performed due to renal function alterations associated to medium-high polyomavirus BK (BKV)-DNA levels on plasma specimen. Results: A total of 21 patients underwent a first biopsy to diagnose a possible BKV nephropathy, in 18, a second biopsy was made, in eight, a third biopsy, and finally, three underwent the fourth renal biopsy; following the results of each biopsies, immunosuppressant agents dosages were modified in order to reduce the effect of PVAN. Conclusions: In this study, the clinical and histological features of 21 kidney transplant recipients with BKV reactivation and development of PVAN are described. To date, the only treatment for PVAN consists in the reduction of immunosuppressive agents, constantly monitoring viral load. View Full-Text
Keywords: BKV; nephropathy; immunosuppression BKV; nephropathy; immunosuppression
Show Figures

Figure 1

MDPI and ACS Style

Zanotto, E.; Allesina, A.; Barreca, A.; Sidoti, F.; Gallo, E.; Bottino, P.; Iannaccone, M.; Bianco, G.; Biancone, L.; Cavallo, R.; Costa, C. Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19. Viruses 2020, 12, 1047. https://0-doi-org.brum.beds.ac.uk/10.3390/v12091047

AMA Style

Zanotto E, Allesina A, Barreca A, Sidoti F, Gallo E, Bottino P, Iannaccone M, Bianco G, Biancone L, Cavallo R, Costa C. Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19. Viruses. 2020; 12(9):1047. https://0-doi-org.brum.beds.ac.uk/10.3390/v12091047

Chicago/Turabian Style

Zanotto, Elisa, Anna Allesina, Antonella Barreca, Francesca Sidoti, Ester Gallo, Paolo Bottino, Marco Iannaccone, Gabriele Bianco, Luigi Biancone, Rossana Cavallo, and Cristina Costa. 2020. "Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19" Viruses 12, no. 9: 1047. https://0-doi-org.brum.beds.ac.uk/10.3390/v12091047

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop