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Coagulopathy in Acute Puumala Hantavirus Infection

1
Department of Internal Medicine, Tampere University Hospital, Elämänaukio 2, 33520 Tampere, Finland
2
Department of Virology, Medicum, University of Helsinki, Haartmaninkatu 21, 00014 Helsinki, Finland
3
Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland
4
Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland
*
Author to whom correspondence should be addressed.
Academic Editor: Karla Helbig
Received: 8 June 2021 / Revised: 27 July 2021 / Accepted: 2 August 2021 / Published: 6 August 2021
(This article belongs to the Special Issue Hantavirus Research in Finland)
Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis. View Full-Text
Keywords: Puumala hantavirus; coagulation; complement system; fibrinolysis; endothelium; platelet; acute kidney injury; DIC Puumala hantavirus; coagulation; complement system; fibrinolysis; endothelium; platelet; acute kidney injury; DIC
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MDPI and ACS Style

Koskela, S.; Mäkelä, S.; Strandin, T.; Vaheri, A.; Outinen, T.; Joutsi-Korhonen, L.; Pörsti, I.; Mustonen, J.; Laine, O. Coagulopathy in Acute Puumala Hantavirus Infection. Viruses 2021, 13, 1553. https://0-doi-org.brum.beds.ac.uk/10.3390/v13081553

AMA Style

Koskela S, Mäkelä S, Strandin T, Vaheri A, Outinen T, Joutsi-Korhonen L, Pörsti I, Mustonen J, Laine O. Coagulopathy in Acute Puumala Hantavirus Infection. Viruses. 2021; 13(8):1553. https://0-doi-org.brum.beds.ac.uk/10.3390/v13081553

Chicago/Turabian Style

Koskela, Sirpa, Satu Mäkelä, Tomas Strandin, Antti Vaheri, Tuula Outinen, Lotta Joutsi-Korhonen, Ilkka Pörsti, Jukka Mustonen, and Outi Laine. 2021. "Coagulopathy in Acute Puumala Hantavirus Infection" Viruses 13, no. 8: 1553. https://0-doi-org.brum.beds.ac.uk/10.3390/v13081553

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