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Volume 15
Issue 12
10.3390/v15122345
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Systematic Review
Peer-Review Record

Diagnostic Efficacy of Serological Antibody Detection Tests for Hepatitis Delta Virus: A Systematic Review and Meta-Analysis

Viruses 2023, 15(12), 2345; https://0-doi-org.brum.beds.ac.uk/10.3390/v15122345
by Zhenzhen Pan 1,†, Sisi Chen 2,†, Ling Xu 1, Yao Gao 1, Yaling Cao 1, Zihao Fan 1, Yuan Tian 1, Xiangying Zhang 1, Zhongping Duan 2 and Feng Ren 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Viruses 2023, 15(12), 2345; https://0-doi-org.brum.beds.ac.uk/10.3390/v15122345
Submission received: 4 November 2023 / Revised: 21 November 2023 / Accepted: 24 November 2023 / Published: 29 November 2023
(This article belongs to the Special Issue Life Cycle of Hepatitis D Virus (HDV) and HDV-Like Agents)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

This is a very detailed meta-analysis of the accuracy of existing anti-HDV assays. I have just some suggestions for the Discussion:

1) Can the Authors discuss the fact that as of today there is no standard reference assay, and that this should be a priority for regulatory agencies?

2) Do HDV genotypes influence the accuracy of anti-HDV testing? 

3) Why the CLIA were not included in the analysis?

4) Can the Authors explain why all reference studies are mentioned twice in Figure 3D?

4) can the Author mention and comment upon the studies by Brichler S, et al. J Clin Microbiol 2014;52:1694-1697; Lin GY, et al. Virol J 2020;17:76.; and Rocco C, et al. Diagn Microbiol Infect Dis 2019;95:114873

 

 

Comments on the Quality of English Language

Minor language editing: please be consistent, names which are abbreviated should be mentioned in extenso again (Hepatitis D Virus etc.)

The reference list requires major attention: several names of Authors are misspelled

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

1.    Authors should discuss whether agents leading to functional cure of HBV are ideal for both HBV and HDV.

2.    Give the several comments on that HDV viremia played a crucial role in HCC development in CHB patients who underwent NA therapy.

3.    Add the reference: Sasaki T, et al. Hepatol Res. 2023 Oct;53(10):960-967. doi: 10.1111/hepr.13936. PMID: 37332115; Omata M, et al. Hepatogastroenterology. 1985 Oct;32(5):220-3.PMID: 4077011.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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