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Review

Associations of Dietary Intake on Biological Markers of Inflammation in Children and Adolescents: A Systematic Review

by
Melissa Bujtor
1,
Anne I. Turner
1,
Susan J. Torres
1,
Laura Esteban-Gonzalo
2,
Carmine M. Pariante
3 and
Alessandra Borsini
3,*
1
Institute for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC 3125, Australia
2
Nursing Department, Faculty of Medicine, Autonomous University of Madrid, 28029 Madrid, Spain
3
Stress, Psychiatry and Immunology Laboratory, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College, London SE5 9RT, UK
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(2), 356; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13020356
Submission received: 24 December 2020 / Revised: 19 January 2021 / Accepted: 21 January 2021 / Published: 25 January 2021
(This article belongs to the Special Issue Nutrition and CNS: In Health and Disease)
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Versions Notes

Abstract

:
Background: In children and adolescents, chronic low-grade inflammation has been implicated in the pathogenesis of co- and multi-morbid conditions to mental health disorders. Diet quality is a potential mechanism of action that can exacerbate or ameliorate low-grade inflammation; however, the exact way dietary intake can regulate the immune response in children and adolescents is still to be fully understood. Methods: Studies that measured dietary intake (patterns of diet, indices, food groups, nutrients) and any inflammatory biomarkers in children and adolescents aged 2 to19 years and published until November 2020 were included in this systematic review, and were selected in line with PRISMA guidelines through the following databases: Academic Search Complete, CINAHL, Global Health, Medline COMPLETE and Web of Science–Core Collection. A total of 53 articles were identified. Results: Results show that adequate adherence to healthful dietary patterns such as the Mediterranean diet, or food groups such as vegetables and fruit, or macro/micro nutrients such as fibre or vitamin C and E, are associated with decreased levels of pro-inflammatory biomarkers, mainly c-reactive protein (CRP), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α), whereas adherence to a Western dietary pattern, as well as intake of food groups such as added sugars, macro-nutrients such as saturated fatty acids or ultra-processed foods, is associated with higher levels of the same pro-inflammatory biomarkers. Conclusions: This is the first systematic review examining dietary intake and biological markers of inflammation in both children and adolescents. A good quality diet, high in vegetable and fruit intake, wholegrains, fibre and healthy fats ameliorates low-grade inflammation, and therefore represents a promising therapeutic approach, as well as an important element for disease prevention in both children and adolescents.

1. Introduction

Inflammation is a physiological response to cellular and tissue damage. It is designed to protect the host from bacteria, viruses and infections by eliminating pathogens, promoting cellular repair and restoring homeostatic conditions [1]. However, a prolonged inflammatory state through chronic low-grade inflammation has deleterious effects, including irreparable damage to tissues and organs, and increased risk of disease status [2].
Low-grade inflammation, reflected in the overproduction of acute phase proteins such as C-reactive protein (CRP), pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumour necrosis factor-alpha (TFN-α) has been established as a risk factor for several neuropsychiatric disorders [3], including depression [4,5,6,7] and schizophrenia [8]. Moreover, low-grade inflammation in children and adolescents has been associated with the development of co- and multi-morbid conditions to mental health pathologies [9,10,11,12], including cardiovascular disease [13,14], metabolic syndrome [15], type-II diabetes [16] and obesity [17], therefore making inflammation an important therapeutic target to study, especially for individuals suffering from those conditions.
The potential factors that promote low-grade chronic inflammation are diverse. Stressors such as trauma through adverse childhood experiences, psychosocial stress, as well as modifiable lifestyle sources such as limited physical exercise or smoking are all capable of evoking a deleterious inflammatory response. Increasingly, attention has been given to diet quality as a potential mechanism of action that can exacerbate or ameliorate low-grade inflammation and subsequently influence mental health [18,19]. Certainly, healthy dietary patterns of high quality, such as adherence to a Mediterranean Diet [20], or eating foods such as vegetables and fruit [1], or macro/micronutrients, such as omega-3 poly-unsaturated fatty acids (PUFAs) [21] or vitamins C and E [22], respectively, have been shown to reduce systemic inflammation [23,24]. In observational and interventional studies, a higher quality diet, comprised of these nutrients, has been associated with a reduced risk of adverse mental health in both children [25] and adolescents [26,27]. In contrast, the prevailing Western dietary pattern, which is high in refined grains, red meat, refined sugar and saturated fat, elicits a pro-inflammatory response and increasing levels of circulating inflammatory biomarkers [21].
Moreover, it is well established that a healthy diet in childhood and adolescence is crucial for optimal growth and development and for disease prevention [28]. For example, higher vegetable intake in childhood has been associated with a lower risk of developing mental health pathologies later in life [29], such as depression. In addition, a healthy diet can contribute to the prevention of cardio-metabolic multi-morbidities, often seen in adult patients with neuropsychiatric conditions [30]. As such, modifying dietary intake as early as during childhood and adolescence represents a promising therapeutic strategy in order to maintain a regular immune response, and to reduce the risk of adverse mental health disorders and associated co- and multi-morbid conditions later in life.
Former literature reviews in children and adolescents have focused on various aspects of diet and various biomarkers that, however, are not specifically related to the immune system function and response [31,32,33]. Therefore, to the best of our knowledge this is the first systematic review bringing together the current evidence base from observational and interventional studies investigating associations between dietary intake, by means of dietary patterns, food groups, macronutrients or micronutrients, and biological markers of low-grade inflammation, including CRP, IL-6 and TNF-α among others, in both children and adolescents.

2. Materials and Methods

This systematic review complies with the PRISMA Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines and is registered with PROSPERO (registration code: CRD42020215954) [34]. It comprises papers published until November 2020 and identified across the following databases: Academic Search Complete, CINAHL, Medline COMPLETE, PsycInfo, Embase and Web of Science. Search terms included “dietary intake” OR “dietary pattern” OR “food groups” OR “macronutrients” OR “micronutrients” AND “inflammation” OR “immune biomarkers” OR “inflammatory biomarkers” AND “children” OR “adolescents” and related terms. The selected studies met the following inclusion criteria: peer-reviewed original research articles involving children and adolescents aged 2–19 years, describing associations between inflammation and/or: (a) patterns or indices of dietary intake, such as the Mediterranean Diet, the Western Dietary pattern, and the Healthy Eating Index, (b) food groups such as fruit and vegetables, whole and refined grains and dairy, (c) macronutrients, such as fat and fibre, and (d) micronutrients, such as vitamins A and C. Whereas, exclusion criteria included: non-peer reviewed article publications, studies in a language other than English, animal studies, studies in pregnant women that only examined maternal diet, and supplementation interventions or dietary rehabilitation interventions for malnutrition. The search included studies published until December 2020. Overall, a total of 53 studies met the inclusion criteria for our review (see Figure 1) and were assessed for risk of bias following the Cochrane risk-of-bias (RoB 2.0) for intervention studies, and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist for observational studies [35,36], see Supplement S1. The majority of the studies included in this review had a low risk of bias.

3. Results

The 53 studies included in this review have been categorized into: (1) dietary patterns and indices (see Table 1), (2) food groups and (3) macronutrients and micronutrients (see Table 2). In particular, 26 studies examined dietary patterns and indices, 15 studies examined food groups, 19 studies examined macronutrients and 7 studies examined micronutrients, while some studies examine more than one category. In total, there were 8 interventional studies, and 45 observational studies, of which 2 were longitudinal [37,38], while the remaining 43 studies were cross-sectional.

3.1. Dietary Patterns

Out of the 53 studies, 17 examined a priori dietary patterns which are based on countries dietary guidelines [9]. The examined dietary patterns included the Dietary Approaches to Stop Hypertension (DASH) dietary pattern, low and high glycaemic index dietary patterns, the Mediterranean dietary pattern and the Western dietary pattern. Two studies examined more than one dietary pattern [39,40].

3.1.1. DASH Dietary Pattern

The DASH dietary pattern was examined in one intervention study [41] and one observational study [40]. The first study found adherence to a DASH diet and lower levels of CRP, in a female cohort of patients with metabolic syndrome [41]. In contrast, the second study did not find an association between adherence to a DASH diet and CRP in a cohort of males and females with type-1 diabetes [40].

3.1.2. Low and High Glycaemic Index Dietary Pattern

Low and high glycaemic index diet patterns were examined in four interventional studies [42,43,44,45]. These studies found that adherence to a low glycaemic index diet pattern or to a hypocaloric high glycaemic index diet pattern was associated with lower levels of CRP, both in males and females with obesity.
In particular, the first study found an association between adherence to a low glycaemic index diet and lower levels of CRP and IL-6 in females with obesity or overweight [45]. Another two studies found an association between adherence to both a hypocaloric low and a hypocaloric high glycaemic index diet and lower levels of high sensitivity c-reactive protein (hs-CRP) in males and females with obesity [43,44]. In contrast, a fourth study did not find any associations between low and high glycaemic index diet patterns and inflammatory outcomes in a healthy cohort of male and female participants [42].

3.1.3. Mediterranean Dietary Pattern

The Mediterranean dietary pattern was examined in 10 observational studies [39,40,46,47,48,49,50,51,52,53], one of which was also discussed in Section 3.1.1 [40]. These studies found that adherence to a Mediterranean dietary pattern was associated with lower levels of CRP, IL-6, and TNF-α in healthy males and females, whereas the majority of studies conducted in cohorts with underlying pathologies, including type-1 diabetes and obesity, found no associations with inflammatory biomarkers.
Two studies, in particular, found an association between a Mediterranean diet pattern and lower levels of hs-CRP in females only [52], or both in males and females [46], whereas another study found an inverse association between a Mediterranean diet and IL-1, IL2, IL-6 and TNF-α both in males and females [48], all studies were conducted in cohorts of healthy participants. In contrast, one study found a positive association between a Mediterranean diet pattern, and CRP and transforming growth factor beta 1 (TGFβ-1) in males only, but an inverse association with soluble vascular cell adhesion molecule-1 (sVCAM-1) in male and females [47], again the study was conducted in a cohort of healthy participants. Another study found an association between a Mediterranean diet pattern and lower levels of IL-4 and IL-17, but higher levels of IL-33, in both males and females with asthma [49]. In contrast, one study in a type-1 diabetic cohort [40], three studies in obese cohorts [50,51,53], and one study in a healthy cohort [39] did not find any associations.

3.1.4. Western Dietary Pattern (WDP)

The WDP was examined in three observational studies [37,39,54]; one study was aforementioned in Section 3.1.3 [39]. These studies found that adherence to a WDP was associated with higher levels of CRP in a cohort of healthy males and females.
The first study was longitudinal and found an association between WDP adherence at 14-years and higher levels of hs-CRP at 17-years both in healthy males and females [37]. The remaining two studies found an association between WDP adherence, and higher levels of CRP and IL-6 in this case in female cohorts of healthy participants [39,54].

3.2. Indices

Out of the 53 studies, 11 examined dietary indices, including the dietary inflammatory index, healthy eating index and the diet quality index. One study examined both a pattern and an index [51], while another study examined two patterns and one index [40].

3.2.1. Dietary Inflammatory Index (DII)

The DII, a tool that assesses the inflammatory potential of a diet [32], was examined in 6 observational studies [38,51,55,56,57,58], one of which was also discussed in Section 3.1.3 [51]. These studies found that adherence to a pro-inflammatory diet (indicated by a higher score in the DII) was associated with higher levels of hs-CRP, IL-6 and TNF-α in healthy males and females.
In particular, four studies found a positive association between adherence to a pro-inflammatory diet (indicated by a higher score in the DII) and IL-6 [55,57], IL-1, IL-2, interferon gammon and sVCAM-1 in healthy males and females [58], but also a positive association between DII and CRP in males and females with obesity [51]. However, two studies did not find any associations between the DII and CRP [38], or IL-6, MCP-1 or TNF-α [56] in neither healthy males or females.

3.2.2. Healthy Eating Index (HEI)

The HEI, a tool that assesses adherence to the Dietary Guidelines of Americans in any given year, was examined in three observational studies [40,59,60]. One of which was also discussed in Section 3.1.1 and Section 3.1.3 [40]. The first study found that a higher score in the HEI (healthy diet) was associated with lower levels of CRP in females, but not males from a healthy cohort [59]. In contrast, two studies found that moderate HEI scores (moderately healthy diet) were not associated with CRP or IL-6 in males or females in cohorts of patients with type-1 diabetes [40,60].

3.2.3. Diet Quality Index (DQI)

The DQI, a composite individual-level diet quality indicator that enables cross-cultural diet quality comparisons was examined in two observational studies [61,62]. Neither of the studies found an association between the DQI and CRP [61,62] or IL-1, IL-6, IFN-y and TNF-α [62]. This suggests a lack of sensitivity associated with the DQI as a measure of inflammatory status.

3.3. Food Groups

Out of the 53 studies, 15 examined food groups, in particular: (1) vegetables and fruits, (2) dairy, (3) meat, seafood and eggs, (4) whole and refined grains, and (5) added sugars.

3.3.1. Vegetables and Fruits

Vegetable and/or fruit intake was examined in nine observational studies [47,59,60,63,64,65,66,67,68], two of which were also discussed in Section 3.2.2 [59,60]. These studies found that high dietary intake of vegetables and/or fruits was associated with lower levels of CRP and IL-6 (both in healthy males and females), TNF-α (only in healthy females), and IL-17F (both male and female patients with asthma).
In particular, three studies found an association between vegetable and fruit intake and lower levels of CRP [63,64,65], and IL-6 and TNF-α [66], both in healthy males and females, as well as in males and females with obesity [69]. In contrast, one study found an association between vegetable and fruit intake and lower levels of hs-CRP in healthy females, but not in males [59]. While another found an association between vegetable and fruit intake and higher levels of CRP in males, but not in females, lower levels of IL-4 in males and females, and lower levels of TNF-α in females, but not in males, and higher levels of IL-10 in males and females, in a cohort of healthy participants [47]. While one study found an association between fruit and vegetable intake and lower levels of IL-17F in males and females from a cohort of patients with asthma [67], another study found no associations between vegetable and fruit intake and CRP in a cohort of male and female patients with type-1 diabetes [60].

3.3.2. Dairy

Dairy was examined in seven observational studies [47,60,63,64,67,68,69], six of which were also discussed in Section 3.3.1 [47,60,63,64,67,69], and one in Section 3.1.3 [47]. One study found an association between dairy intake and higher levels of IL-17F in males and females, from a cohort of patients with asthma. However, the majority of studies did not find an association between dairy intake and CRP or IL-6 in males or females from healthy cohorts.
One study found an association between dairy intake and higher levels of IL-17F in males and females from a cohort of patients with asthma [67] while a second study found an association between dairy intake and higher levels of IL-6, Il-10 and TGFβ-1 in females, but not in males, and IL-1 in both males and females, and IL-5 in males but not in females in a healthy cohort [47]. The remaining five studies did not find any associations between dairy intake and CRP and IL-6 in males and females from healthy cohorts [60,63,64,68,69].

3.3.3. Meat, Seafood and Eggs

Meat, seafood and eggs were examined in seven observational studies [47,60,63,64,67,69,70], six of which were also discussed in Section 3.3.1 and Section 3.3.2 [47,60,63,64,67,69], and one in Section 3.1.3 [47]. The majority of studies did not find an association between dietary intake of meat, seafood and eggs and CRP, IL-6 and TNF-α in males and females from healthy cohorts.
Two studies, in healthy populations found an association between meat intake and higher levels of IL-2, IL-10 [47] and IL-6 [70] in healthy males and females, however the remaining five studies did not find any associations between meat, seafood or eggs intake and CRP, IL-6 and TNF-α [60,63,64,67,69].

3.3.4. Whole and Refined Grains

Whole and refined grains were examined in one intervention [71] and six observational [47,63,64,67,69,72] studies, six of which were also discussed in Section 3.3.1, Section 3.3.2 and Section 3.3.3 [47,63,64,67,69], and one in Section 3.1.3 [47]. These studies found that wholegrain dietary intake was associated with lower levels of CRP and IL-17F in males and females from cohorts with and without underlying pathologies. In contrast, results on the association between refined grain intake and inflammatory markers remain inconclusive.
In particular, the first study found an association between wholegrain intake and lower levels of CRP in a female only cohort of participants with obesity [71]. The second study found an association between wholegrain intake and lower levels of IL-17F in males and females from a cohort of patients with asthma [67]. A third study found an association between wholegrain intake and lower levels of CRP, in males and females from a healthy cohort [72].
The remaining studies examined refined grains in healthy populations. One study reported an association between refined grain intake and lower levels of hs-CRP in males and females [64], while another study found an association with higher levels of CRP, only in females but not in males [63]. A third study found refined grains were associated with lower levels of IL-6 and IL-10 in males and females [47]. Lastly, one study found no association between refined grain intake and CRP in males and females [69].

3.3.5. Added Sugar and Sugar Sweetened Beverages (SSB)

Added sugars (snacks—candy, jams, spreads, sugar sweetened beverages, fruit juice) were examined in one interventional [73] and eight observational [50,60,63,65,66,67,69,74] studies, two of which were also discussed in Section 3.2.1, Section 3.2.2 and Section 3.2.3 [67,69]. The majority of studies did not find an association between added sugar intake and CRP, for males or females from cohorts with healthy participants, as well as for patients with inflammatory bowel disease, Type-1 diabetes and obesity.
In particular, the first study found glucose intake decreased levels of hs-CRP, compared with fructose in a cohort of male and female patients with non-alcohol fatty liver disease [73]. Another study found an association between higher SSB intake and higher levels of CRP in males and females from a cohort of healthy participants [74]. Another two studies found an association between SSB intake and higher levels of CRP in females, but not in males in a cohort of healthy participants [63], and IL-17F in both males and females from a cohort of patients with asthma [67]. Five studies found no association between added sugar intake and CRP, IL-6 and TNF-α from cohorts of healthy participants [66,69], patients with inflammatory bowel disease, Type-1 diabetes [60] and obesity [50].

3.4. Macronutrients

A total of 19 studies examined macronutrients, including (1) fats and (2) fibre.

3.4.1. Fats

Fat was examined in 13 observational studies [39,47,50,59,60,64,70,75,76,77,78,79,80], 8 of which were also discussed in Section 3.1.3 [39,50], Section 3.1.4 [39], Section 3.2.2 [59] Section 3.3.1 [59,60,64], Section 3.3.2 [60,64], Section 3.3.3 [60,64,70], Section 3.3.4 [60,64], and Section 3.3.5 [50,60]. The studies found that saturated fatty acids (SFAs) intake was associated with higher levels of CRP, IL-6, Transforming growth factor-beta and sVCAM-1, while monounsaturated fatty acid (MUFA) intake was associated with lower levels of IL-6, and omega-3 PUFA intake was associated with lower levels of plasminogen activator inhibitor-1, in males and females from cohorts of healthy participants.
These studies found an association between SFAs and higher levels of CRP in females, but not in males from a cohort of healthy participants [59], as well as in male and female obese participants [70]. In contrast, one study found a positive association between SFA intake and CRP in males, but not in females from a cohort of healthy participants [67]. Another study found an inverse association between dietary intake of MUFA and IL-6, as well as between omega-3 PUFAs and plasminogen activator inhibitor-1, in a female cohort of healthy participants [39]. Another study found a positive association between MUFA:SFA ratio and IL-6 in males and females, TGFβ-1 in females but not in males, and sVCAM-1 in males but not in females, from a cohort of healthy participants [47]. The same study also found an inverse association between SFA and sVCAM-1 in females but not in males [47]. Lastly, seven studies found no associations between SFA and CRP [60,76] and total fat and CRP [50,64,75,79,80] or IL-6 [80].

3.4.2. Fibre

Fibre was examined in one intervention [81] and nine observational [50,59,64,76,78,82,83,84,85] studies, five of which were also discussed in Section 3.1.3 [50], Section 3.2.2 [59], Section 3.3.1 [59,64], Section 3.3.2 [64], Section 3.3.3 [64], Section 3.3.4 [64], Section 3.3.5 [50], and Section 3.4.1 [50,76]. Results show that, while six studies did not find an association between fibre intake and CRP in males or females from healthy cohorts, four studies found an association between fibre intake and lower levels of CRP, TNF-α, plasminogen activator inhibitor-1, and monocyte chemoattractant protein-1 in males and females, from cohorts of healthy participants.
The first study found an association between dietary fibre intake and higher levels of TNF-α in males and females from a cohort of healthy participants [81]. Another two studies in healthy participants found an association between dietary fibre intake and lower levels of CRP in females, but not in males [59], or both in males and females [85]. A fourth study found that total fibre intake was inversely associated with plasminogen activator inhibitor-1, while insoluble fibre was inversely associated with plasminogen activator inhibitor-1 and monocyte chemoattractant protein-1, in males and females from a cohort of overweight participants [86]. Lastly, six studies found no associations between fibre intake and CRP in males or females from cohorts of healthy participants [64,78,82,83,84], or in obese participants [50].

3.5. Micronutrients

A total of seven observational studies examined various micronutrients [39,59,66,79,87,88,89]. Three of the studies were also discussed in Section 3.2.2 [59], Section 3.3.1 [59,66] and Section 3.4.1 [59,79]. These studies found an association between dietary intakes of vitamins and lower levels of CRP and IL-6, while sodium was associated with higher levels of TNF-α, in males and females from a cohort of healthy participants [87].
Vitamin C intake was associated with lower levels of hs-CRP and IL-6 in males and females from a cohort of healthy participants. [66]. Dietary intake of beta-carotene was associated with lower levels of IL-6 and TNF-α [66], while vitamins A and E were inversely associated with hs-CRP, in males and females from cohorts of healthy participants [59]. Magnesium was inversely associated with hs-CRP in healthy male and female participants [88] and positively associated with IL-6 in healthy females [39]. One study examined sodium intake and found a positive association with TNF-α in healthy males and females [87]. However, two studies found no associations between micronutrient intake and CRP in males and females from healthy populations [79,89].

4. Discussion

This review provides the first evidence for the association between dietary intake (dietary patterns, food groups, macronutrients and micronutrients) and biological markers of inflammation in children and adolescents. The main results (Table 1 and Table 2, Figure 2) indicate that adequate adherence to healthful dietary patterns, such as the DASH diet, low glycaemic index diets and the Mediterranean diet are associated with decreased levels of biomarkers, including CRP, IL-6 and TNF-α. Among the individual constituents of these diets, vegetable and fruit intake and wholegrains, as well as healthy fats were associated with a favourable inflammatory response. In contrast, a Western dietary pattern, as well as its separate constituents including saturated fatty acid, elicited a pro-inflammatory response increasing levels of pro-inflammatory biomarkers, such as CRP, IL-6, TNF-α and sVCAM-1. Associations across the studies included in this review were attenuated by gender, as well as the presence of underlying pathologies, independent of dietary intake.
Traditionally diet–disease relationships have been examined by focusing on nutrients or food groups, which can be limiting. Foods are typically eaten in combination, and nutrients have both synergistic and antagonistic biochemical interactions [90]. More recently, dietary patterns that capture the whole diet, involving the combination of foods and nutrients have been examined [91]. The most examined dietary pattern in this review was the Mediterranean diet and in observational studies conducted in healthy populations adequate to high adherence resulted in decreased levels of pro-inflammatory biomarkers [46,48,52]. Similar results were found for studies examining low glycaemic index diets in obese populations [43,44,45] and one intervention study in females with metabolic syndrome which examined the DASH diet [41].
The mechanisms by which these healthful dietary patterns affect the inflammatory process are largely underexplored [18]. It has been hypothesised that the protective effect of these patterns may be derived from the anti-inflammatory properties of their constituents [92]. The Mediterranean diet is characterized by high intakes of vegetables, fruit, wholegrains, legumes, nuts, fish and low-fat dairy, and low intakes of red meat and adequate intakes of healthy fats [93]. As such, the diet is rich in antioxidants, folate, and flavonoids which are anti-inflammatory. The high dietary fibre content supports gut health and the growth of microbial species which potentially regulate the inhibition or production of pro-inflammatory chemokines and cytokines [94]. Omega-3 PUFAs, found in high concentration in oily fish such as salmon, have been shown to regulate the immune response by inhibiting the activation of pro-inflammatory pathways and reducing cytokine expression [3]. High-dose eicosapentaenoic acid has been shown to improve cognitive symptoms in Attention deficit hyperactivity disorder (ADHD) youth with low baseline levels [95,96], while research in animal models has demonstrated inflammation-induced reductions in neurogenesis can be prevented through omega-3 PUFAs intake [97]. Lastly, sodium intake has been implicated in the regulation of the immune response [98]. The DASH diet, which is similar to the Mediterranean diet, with a greater focus on minimal red meat and processed foods, also restricts sodium intake [99]. Similar to sodium, the studies included in this review also examined other dietary components with strong anti-inflammatory properties. For example, studies showed that high intakes of vegetables and fruit [59,63,64,65,66,67,69], and whole-grains [67,72] resulted in lower levels of inflammatory biomarkers, such as CRP, IL-6 and TNF-α. The same was for various micronutrients such as beta-carotene [66] and vitamins C and E [39] all of which are considered to have anti-inflammatory properties [100].
In contrast to healthful dietary patterns, studies that examined the Western dietary pattern, characterised by high amounts of refined grains, red meat, high fat dairy, ultra-processed food intake and trans fatty acids while being low in omega-3 PUFAs [101,102] showed positive associations with pro-inflammatory markers [37,54]. Similarly, in the studies that examined the DII, diets with high inflammatory potential, inducing a higher inflammatory response were positively associated with pro-inflammatory biomarkers in males and females [51,55,57,58]. In terms of separate components comprising these diets, saturated fatty acid intake is known to be a significant pro-inflammatory contributor that stimulates IL-6 secretion, while in contrast high intakes of healthier fats, such as omega-3 PUFAs found in oily fish can inhibit the inflammatory response [103]. Across the studies that examined saturated fatty acids in this review there was evidence for a positive association between saturated fatty acid and CRP, as well as various cytokines, IL-6, sVCAM and sICAM [59].
As demonstrated in this review, the relationship between diet and inflammation is attenuated by a number of different factors [1,104,105]. For example, gender differences were evident across the studies included in this review, however, they were not specific to one particular diet, food group, macro- or micronutrient. Nor where they specific to any inflammatory biomarker. We hypothesize the gender difference is potentially attributable to the influence of hormones. Sex hormones affect immune function, whereby estrogens stimulate auto-immunity and androgens exhibit protective properties [106,107,108,109]. Other evidence indicates genetic, epigenetic and environmental factors may also contribute to gender differences; however, no included studies explored these potential associations [109,110]. Furthermore, we acknowledge the heterogeneity in the cohorts of the studies included in this review, and as such some associations could have been confounded by the sample population. A number of studies examined cohorts with underlying pathologies, with overweight/obesity [42,43,44,45,50,51,53,70,71,75,81,86], and type-1 diabetes [40,60,82] being the most studied. In overweight and obese populations excess adipose tissue has been linked to an increase in sub-chronic levels of key pro-inflammatory cytokines, mainly CRP, IL-6 and TNF-α [111], and this may prevent or attenuate any potential therapeutic effect exerted by a healthful diet [112]. Taken together, physiologic mechanisms specific to disease state or population may inhibit any beneficial influence of a healthy dietary pattern, potentially explaining the lack of significant associations in the studies discussed in our review [82].
With regards to methodology, it is widely accepted that nutrition epidemiology studies are affected by reporting bias. Imprecision in the measurement of dietary intake is often observed, particularly in children and adolescents, which can cause the over- or under- estimation of the impact of exposure [113,114,115]. Moreover, the measurement tools themselves are often flawed, for example the KidMed questionnaire, used to evaluate the level of adherence to the Mediterranean diet, has a strong bias toward healthy foods and as such may not adequately capture hidden constituents such as sodium [116]. These methods also do not consider the biological effect of food (intake versus absorption) [117]. More recently, several studies have examined associations between biological markers of dietary intake and pro-inflammatory biomarkers. Using these methods, an inverse association between fatty acid composition in erythrocytes and pro-inflammatory biomarkers (IL-1β and IL-6) has been observed in children and adolescents [118], and higher omega-6/omega-3 PUFAs ratio has been associated with higher levels of inflammation [119] and subsequent adverse mental health effects [120]. These biological, rather than self-reported, dietary measures are a more accurate and reliable way of investigating dietary intake, which should be more often used in future research studies [121].
Lastly, there is currently no consensus regarding the inflammatory biomarkers best used to represent chronic low-grade inflammation in children and adolescents, and biomarker measurement error such as sampling, storage and laboratory errors also cannot be excluded [122]. The majority of the studies in this review used a single static measurement of inflammation, however, inflammatory markers owing to their role in homeostasis and immune response are by nature not static and when measured in the fasting state are recognised as being insensitive, and producing highly variable results [2]. Multiple, non-fasting state measures would provide for more accurate and meaningful outcomes.

5. Conclusions

In conclusion, our review shows that healthful dietary patterns such as the Mediterranean diet, high in vegetables, fruit, wholegrains, legumes, nuts, fish and low-fat dairy, alongside moderate to low consumption of meat and healthy fats, have an inverse association with pro-inflammatory biomarkers, particularly CRP, IL-6 and TNF-α, in children and adolescents. Components of healthful diets that were examined separately, including food groups such as vegetables and fruit, or macronutrients such as fibre, or micronutrients such as Vitamins A, C and E also have inverse associations with pro-inflammatory biomarkers. In contrast, the Western dietary pattern, as well as its individual components including macronutrients such as saturated fatty acids, micronutrients such as sodium and ultra-processed foods, increases levels of the same pro-inflammatory biomarkers. Further interventional research is needed to establish the strength of associations between dietary intake and inflammatory biomarkers, and ultimately to develop a better understanding of the biological mechanisms underlying such associations.

Supplementary Materials

The following are available online at https://0-www-mdpi-com.brum.beds.ac.uk/2072-6643/13/2/356/s1. Supplement S1: RoB2.0 and STROBE risk of bias assessment checklists (completed).

Author Contributions

All authors contributed to the manuscript. All authors have read and agreed to the published version of the manuscript.

Funding

A.B. and C.M.P. are funded by the UK Medical Research Council (grants MR/L014815/1, MR/J002739/1and MR/N029488/1), the European Commission Horizon 2020 (grant SC1-BHC-01-2019) and the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London; they have also received research funding from Johnson and Johnson for research on depression and inflammation, but this paper is independent from this funding. In addition, C.M.P. is funded by the Wellcome Trust strategy award to the Neuroimmunology of Mood Disorders and Alzheimer’s Disease (NIMA) Consortium (104025), which is also funded by Janssen, GlaxoSmithKline, Lundbeck and Pfizer, but, again, this paper is independent from this funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable because it is a systematic review. All data is available in primary studies.

Conflicts of Interest

Authors declare no conflict of interest.

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Nutrients 13 00356 g001 550
Figure 1. Study selection flow chart including reasons for exclusion of studies during full text screening.
Figure 1. Study selection flow chart including reasons for exclusion of studies during full text screening.
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Nutrients 13 00356 g002 550
Figure 2. Association between dietary intake and biomarkers of inflammation in children and adolescents.
Figure 2. Association between dietary intake and biomarkers of inflammation in children and adolescents.
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Table
Table 1. Summary of studies investigating the associations between dietary patterns/scores/indices and biological markers of inflammation in children and adolescents.
Table 1. Summary of studies investigating the associations between dietary patterns/scores/indices and biological markers of inflammation in children and adolescents.
Author and Country
(* also in
Table 2)		Sample CharacteristicsPathology
(Present or Outcome)		Dietary Pattern or Index
(Intervention Period if Applicable)		Components of Dietary Pattern or IndicesBiological Markers of InflammationMain Findings
↑ Increase/Positive Association
↓ Decrease/Negative or Inverse Association
↔ No Association
Experimental
Damsgaard et al. (2012)
(Europe) [42]		n = 253
13.2 (10.6–16.2) female
12.8 (10.3–15.2) male
51% female		Parents were overweight/obese
Present		Randomized to 1 of 5 diet patterns:
1. High Protein Diet Pattern
2. Low Protein Diet Pattern
3. HGI Diet Pattern
4. LGI Diet Pattern
5. Control
(6 months)		High protein/low protein
High GI/low GI		hs-CRPPatterns—high protein, low protein, high GI, low GI, control: ↔ No associations
Iannuzzi et al. (2009)
(Italy) [43]		n = 26
7–13 years
54% female		Obese
Present		Hypocaloric HGI Diet Pattern
Hypocaloric LGI Diet Pattern		HGI: Energy intake 30% < required for weight maintenance, 25–30% fat, 15–20% protein, 50–60% carbohydrate, high glycaemic index.
LGI: same as HGI diet but mean daily estimated index was 60		CRPHGI intake: CRP ↓
LGI intake: CRP ↓
Parillo et al. (2012)
(Italy) [44]		n = 22
8–13 years
54% female		Obese
Present		Hypocaloric HGI Diet Pattern
Hypocaloric LGI Diet Pattern		HGI: Energy intake < 30% less than reqd. for weight maintenance, 25–30% fat, 15–20% protein, 50–60% carbohydrate, fibre intake 0.5 g/kg and high glycaemic index of 90.
LGI: Same as for HGI diet, but mean daily estimated glycaemic index was 60.		hs-CRPHGI intake: CRP ↓
LGI intake: CRP ↓
Rouhani et al. (2016)
(Iran) [45]		n = 50
Exp-25, 13.28 ± 0.16
Cont-25, 13.93 ± 0.24
100% female		Overweight/obese
Present		LGI Diet Pattern
HND
(10 weeks)		LGI: carbohydrate containing foods from a list of LGI grains, fruits, vegetables, dairy and high glycaemic foods to be avoided (moderately calorie restricted)
HND: based on healthy eating guidelines		CRP, Il-6LGI intake: IL-6 and CRP ↓,
HND intake: Il-6 ↓
All other ↔
Saneei et al. (2014)
(Iran) [41]		n = 60 (30 exp. 30 cont.)
14.2 ± 0.7
100% female		Metabolic syndrome
Present		Randomized to:
DASH Dietary Pattern
Typical Iranian Diet
(cross-over trial: 6-wk cycle, 4 wk wash-out)		DASH Diet
Typical Iranian Diet		CRP, IL-2, IL-6, TNF-α, DASH, compared to typical Iranian diet:
CRP ↓
All other ↔
Observational
Agostinis-Sobrinho et al. (2018)
(Columbia and Portugal) [46]		n = 1462
13.5 ± 2.1
43% female		NAMDPKidmed (16 questions, maximum score 12):
Group 1—optimal adherence (≥8, optimal MedDiet); and
Group 2 and 3—Low adherence (4–7, improvement needed (adjust intake to Med) or ≤3, very low diet quality)		hs-CRPOptimal adherence to MDP + High MF/High CRF: hs-CRP ↓
Optimal adherence to MDP + Low MF/Low CRF: hs-CRP ↑
Low adherence to MedDiet + Low MF/Low CRF: hs-CRP ↑
Almeida-de-Souza et al. (2015)
(Portugal) [55]		n = 329
15.00 (13.0–16.0)
56% female		NADIIDII score was calculated considering 31 food parameters, expressed as tertiles:
Tertile 1—low (<−1.34)
Tertile 2—medium (−1.34 to 1.41)
Tertile 3—high (>1.41)		CRP, IL-6DII: 0.57 ± 0.92–2.07
3rd Tertile compared to 1st:
Il-6 ↑
CRP ↔
Arouca et al. (2017) *
(Europe) [47]		n = 464
14.79 ± 1.24
53% female		NAMDPMDP: MD score (0–9 points, higher scores indicating greater adherence)
Positive components: (1) high ratio of monounsaturated to saturated dietary lipids (mainly olive oil), (2) vegetables, (3) fruits and nuts, (4) fish (5) cereals (6) of pulses
Negative components: (7) meat and meat products (8) milk and dairy products, and (9) any consumption of alcohol (deducted in this study)		CRP, IL-1, IL-2, IL-4, IL-5, IL-6, Il-10, sVCAM-1, sICAM-1, sE-selectin, TNF-α, TGFβ-1MDS (mean 4.23 ± 1.49 boys, 4.19 ± 1.43 girls):
CRP, TGFβ-1 ↑ (boys), sVCAM-1 ↓ (all)
All other ↔
Carvalho et al. (2018)
(Multi-country) [48]		n = 242
14.4 ± 1.1
56.61% female		NAMDPMDP: modified MD score (0–8 points, higher scores indicating greater adherence)
Positive components: (1) high ratio of monounsaturated to saturated dietary lipids (mainly olive oil), (2) vegetables, (3) fruits and nuts, (4) fish (5) cereals (6) of pulses
Negative components: (7) meat and meat products (8) milk and dairy products		CRP, IL-1, IL-2, IL-4, IL-6, TNF-α, MDS: 4.2 ± 1.5
High adherence vs. low adherence: IL-1, IL-2, IL-6, TNF-α ↓ (unadjusted)
Chan et al. (2015)
(Australia) [61]		n = 1419
14 years,
49% female
n = 843
17 years
53.5% female		NADGI-CAModified DGI-CA: score 0–100 points, scores closer to 100 represent maximum compliance, item 10. alcohol excluded
Eleven indicators (1) wide variety of foods, (2) serves of vegetables, legumes, fruit (3) serves of breads and cereals (4) lean meat/fish/poultry (5) milk/yoghurt/cheese (6) plenty of water (7) limited SFA/moderate total fat (8) low salt foods (9) prevent weight gain (10) 		hs-CRPDGI-CA 14-yrs 47.1 ± 10.2; and
DGI-CA17-yrs 47.7 ± 11.0:
↔ No associations reported
Coheley et al. (2019)
(USA) [56]		n = 323
11.38 ± 1.23
57% female		NADIIDII calculated from 27 food parameters available (of 45 recognised in the DII score) from the 3 day food diary, expressed as levels of inflammatory potential:
[<−1.34]—low
[−1.34 to 1.41]—medium
[>1.41]—and high 		IL-6, MCP-1, TNF-αDII: score 0.59 ± 1.36 (pro-inflammatory):
↔ No associations reported
del Mar Bibiloni (2013) *
(Spain) [39]		n = 219
14.9 ± 1.3
100% female		NAWDP
MDP		WDP—yoghurt and cheese, dairy desserts, red meats, poultry, sausages, eggs, bread, cereals, pasta, rice dishes, pizza, fruit juices, canned fruits, nuts, soft drinks, high-fat foods, other oils and fats, sweets and chocolates
MDP—yoghurt and cheese, red meat, poultry, fish and seafood, eggs, legumes, pasta, fresh fruit, fruit juices, vegetables, potatoes, tubercles and olive oil
Participants were categorised across tertiles of the two patterns		hs-CRP, IL-6, PAI-1, TNF-α WDP score: Il-6 ↑, ↔ All other
MDP score: ↔ No associations reported
Douros et al. (2018)
(Greece) [49]		n = 70
Exp-44, 8.9 ± 2.4, 41% female
Cont-26, 8.6 ± 2.1, 35% female		Asthma
Present		MDPKidmed (16 questions, maximum score 12):
Optimal adherence: ≥8, optimal MedDiet
Average adherence: 4–7
Low adherence: ≤3		IL-4, IL-17, IL-33KidMed (mean 5.70 ± 1.94):
Asthmatic only: IL-4, Il-17 ↓ Il-33 ↑
Control: ↔ No associations reported
Karampola et al. (2019) *
(Greece) [50]		n = 142:
Exp-71 (28 overweight/43 obese)
Cont-71
13.4 ± 1.46
46% female		Overweight/obese
Present		MDPKidMed (16 questions, maximum score 12):
Group 1—optimal adherence (≥8, optimal MedDiet);
Group 2 and 3—Low adherence (4–7, improvement needed (adjust intake to Med) or ≤3, very low diet quality)		hs-CRPKidMed—obese—5, overweight—7, controls—6:
↔ No associations reported
Khayyatzadeh et al. (2018)
(Iran) [54]		n = 670
14.5 ± 1.5
100% female		NAWDPWDP: high in refined grains, snacks, red meats, poultry, fish, organ meat, pizza, fruit juices, industrial juice and compote, mayonnaise, nuts, sugars, soft drinks, sweets and desserts, coffee and picklehs-CRPWDP (higher adherence): hs-CRP ↑
Kurklu et al. (2019)
(Turkey) [57]		n = 343
10–16 years
63% female		Metabolic syndrome
Outcome		DIIDII calculated from 31 food parameters available (of 45 recognised in the DII score) from the 3 day food diary, expressed as levels of inflammatory potential:
Quartile 1  =  1.04–3.19
Quartile 2  =  3.19–3.80
Quartile 3  =  3.81–4.31
Quartile 4  =  4.32–5.11		CRP, IL-6, TNF-αDII (range: 1.04–5.11, average 3.6  ±  0.82):
4th quartile compared to 1st quartile: Il-6 ↑
↔ All other
Lazarou et al. (2010)
(Greece) [51]		n = 83
9.2 ± 1.7
50% female		Obesity
Present		MDP
DII		KidMed (16 questions, maximum score 12):
0–3: Poor quality
4–12: at least average quality
Inflammatory Foods Index: composed of nine foods/food groups		hs-CRPKidMeD:
CRP < 0.10 mg/dL: 33% poor quality, 67% at least average quality
CRP > 0.10 mg/dL: 31% poor quality, 69% at least average quality
MDP: ↔ No associations reported
DII (high score): hs-CRP ↑
Liese et al. (2017)
(USA) [40]		n = 2520
14.2 ± 3.0
50% female		Type-1 Diabetes
Present		DASH dietary pattern
HEI-2010
MDP-modified KidMed
TAC		Dietary indices were used to evaluate diet quality in this study; DASH, HEI2010, KidMed and TAC
All indices were coded based on food item, food group and nutrient data		CRP, IL-6DASH (43; possible range 0–80): ↔ No associations reported
HEI-2010 (55; possible range 0–100): ↔ No associations reported
Modified KidMed (3.7; possible range 3–12): ↔ No associations reported
Total Antioxidant Capacity (TAC): ↔ No associations reported
Navarro (2017) *
(Spain) [59]		n = 571
6.8 years
53% female		NAHEIHEI
Pattern 1: fibre, fruit, fruit and vegetable, and vitamin A and E intakes
Pattern 2: fat intake, particularly monounsaturated and polyunsaturated intakes		hs-CRPHEI (higher score 62.8 ± 10.3 females): hs-CRP ↓ (females only, 3rd tertile hs-CRP)
Pattern 1: hs-CRP ↓ (female only)
Pattern 2: ↔ No associations reported
Oddy et al. (2018)
(Australia) [37]		n = 843
14 years
51% female
3-year follow-up		Depression
Outcome		WDP (compared to HDP)WDP: take-away and processed foods, red and processed meats, full-fat dairy, fried potatoes, refined grains, confectionary, soft drink, crisps, sauces and dressings
HDP: wholegrains, fruit, vegetables, legumes and fish		hs-CRPWDP adherence (14-yrs): hs-CRP (17-years) ↑
HDP adherence (14-yrs): hs-CRP (17-yrs) ↓
Sanjeevi et al. (2018) *
(USA) [60]		n = 136
12.7 ± 2.6
% female not reported		Type-1 Diabetes
Present		HEI: representing adherence to Dietary Guidelines of Americans 2015 (diet quality)
(Secondary analysis of a trial that aimed to increase intake of whole plant foods in experimental group—18-month behavioural intervention trial)		Index: HEI-2015 comprised of twelve component scores summed to obtain total score 0–100. Higher score indicates higher adherence to DGA 2015CRPHEI (46.05 ± 11.70):
↔ No associations reported
Sen et al. (2017)
(USA) [38]		n = 922
3.1 years and 7.7 years
% female not reported		NADIIDII derived from FFQ and expressed as quartiles, low to high.hs-CRPDII (highest quartiles—early childhood): hs-CRP, (mid childhood)
↔ No associations reported
Shivappa et al. (2016)
(Europe) [58]		n = 532
12.5–17.5
55% female		NADIIDII derived from 25 food parameters (of 45 recognised in the DII score) and expressed levels of inflammatory potential:
Tertile 1—low inflammation
Tertile 2—medium inflammation
Tertile 3—high inflammation		CRP, IL-1, IL-2, IL-6, IL-4, IL-10, IFN-y, sICAM, sVCAM, TNF-αDII (Tertile 3): IL-1, IL-2, IFN-y, TNF-α, sVCAM ↑
↔ All other
Sureda et al. (2018)
(Spain) [52]		n = 364
12–17 years
60% female		NAMDPMDP: MD score (0–9 points, higher scores indicating greater adherence)
Energy-adjusted, daily consumption values of: legumes, cereals and roots (including bread and potatoes), fruit (including nuts), vegetables, fish, meat (and meat products) and milk (and milk products). Alcohol considered null. Summed then converted to the relative percentage of adherence:
Above median value (≥50%)
Under median value (<50%)		hs-CRP, PAI-1, TNF-αFemales—41% above median (average adherence):
Med Diet Score: hs-CRP ↓, ↔ All other
Males—46% above median (average adherence):
Med Diet Score: ↔ No associations reported
Vyncke et al. (2013)
(Europe) [62]		n = 1804 (biomarker sub-sample 552)
14.7 ± 1.2
53% female		NADQI-ADQI-A score 0–100 points, scores closer to 100 represent maximum compliance derived from intake of:
(1) water, (2) bread and cereals, (3) grains and potatoes, (4) vegetables, (5) fruit, (6) milk products, (7) cheese, (8) meat, fish, eggs, and substitutes, (9) fats and oils		hs-CRP, IL-1, IL-6, IFN-y, TNF-αDQI-A (range 11.1 to 82.5, median 55.0):
↔ No associations reported
Yilmaz et al. (2019)
(Turkey) [53]		n = 95
10–18 years
56% female		Obesity (Present)
Cardiovascular Risk Factors (Outcome)		MDPKidMed (16 questions, maximum score 12):
Optimal adherence: ≥8, optimal MedDiet
Average adherence: 4–7
Low adherence: ≤3		hs-CRPMed Diet Quality (low adherence—60% of participants):
↔ No associations reported
CRP—C-reactive protein; DASH—Dietary Approaches to Stop Hypertension; DGA—Dietary Guidelines of Americans; DGI-CA—Dietary Guidelines Index for Children and Adolescents; DII—Dietary Inflammatory Index; DQI—Diet Quality Index; DQI-A—Diet Quality Index-Adolescents; F&V—Fruit and Vegetable; FFQ—Food Frequency Questionnaire; GI—Glycaemic Index; HDP—Healthy Diet Plan; HEI2010—Healthy Eating Index 2010; HGI—High Glycaemic Index; HND—Healthy Nutritional Diet; hs-CRP—high-sensitivity C-reactive protein; IL-1—Interleukin-1; IL-10—Interleukin-10; IL-2—Interleukin-2; IL-4—Interleukin-4; IL-5—Interleukin-5; IL-6—Interleukin-6; Kidmed—Mediterranean Diet Quality Index for children and teenagers; LGI—Low Glycaemic Index; MCP-1—Monocyte Chemoattractant Protein-1; MDP—Modified Diet Pattern; Med—Mediterranean; MedDiet—Mediterranean Diet; MF—Muscular Fitness; NA—not applicable; PAI-1—Plasminogen activator inhibitor-1; sICAM-1—Soluble intercellular adhesion molecule-1; sVCAM-1—Soluble Vascular Cell Adhesion Molecule-1; TAC—Total Antioxidant Capacity; TGFβ-1—Transforming growth factor beta 1; TNF-α—Tumour necrosis factor alpha; UDA—Usual dietary advice; VEGF—Vascular Endothelial Growth Factor; WDP—Western Dietary Pattern; *—study examines more than 1 category of dietary intake and appears in both Table 1 and Table 2.
Table
Table 2. Summary of studies investigating the associations between food groups and/or nutrients and biological markers of inflammation in children and adolescents.
Table 2. Summary of studies investigating the associations between food groups and/or nutrients and biological markers of inflammation in children and adolescents.
Author and Country
(* also in
Table 1)		Sample CharacteristicsPathology
(Present or Outcome)		Dietary Intake
(Intervention Period If Applicable)		Components ExaminedBiological Markers of InflammationMain Findings
↑ Increase/Positive Association
↓ Decrease/Negative or Inverse Association
↔ No Association
Experimental—Food Groups and Nutrients
Hajihashemi et al. (2014)
(Iran) [71]		n = 44 (22 exp. 22 cont.)
8–15 years
100% female		Overweight/obese
Present		Randomized to:
Whole-grain diet
Control
(cross-over trial—6-week cycle, 2 week run-in, 4 week wash-out)		Food group: whole-grainshs-CRP, sICAM, sVCAM, SAAWholegrains v control: hs-CRP, sICAM, SAA ↓
↔ All other
Jin et al. (2014)
(USA) [73]		n = 21
Exp. 9, 14.2 ± 0.88, 33% female
Cont, 12, 13.0 ± 0.71, 67% female		Non-alcohol fatty liver disease marker (hepatic fat >8%)Randomized to:
Glucose Group
Fructose Group
(4 weeks)		Food group —sugar sweetened beverages containing 33 g of sugar in either fructose or glucose formhs-CRP, PAI-1Post 4 weeks:
Glucose: hs-CRP ↓
↔ All other
Machado et al. (2014)
(Brazil) [81]		n = 75
Exp 1–25, 52% female
Exp 2–25, 48% female
Cont. 25, 56% female
13.7 ± 2.1		Overweight
Present		Randomized to:
Brown Flax Seed (BF)
Golden Flax Seed (GF)
Control
(11 weeks)		Macronutrients: Fibre from provided foods containing brown, golden or no flax seed: coconut cookies, cereal bars, cake, kibbeh, basked stuffed pastries, butter cookiesCRP, interleukin (IL), IL-1B, IL-6, IL-10, INF-y, TNF-αBF, GF, Cont: TNF-α ↑
All other: ↔
Food Groups—Observational
Arouca et al. (2017) *
(Europe) [47]		n = 464
14.79 ± 1.24
53% female		NAFood Groups
Nutrients		Food groups (MedDiet constituents): vegetables, fruits, nuts, pulses, cereals and roots, dairy, fish, meat
Macronutrient: MUFA, 		CRP, IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, sVCAM-1, sICAM-1, sE-selectin, TNF-α, TGFβDietary Intake:
Vegetables and fruit: IL-10 ↑ (all, females), CRP ↑ (males), IL-4 ↓ (all, females), TNF-α ↓ (females)
Pulses: IL-5 ↑ (males), IL-6 ↑ (all, males), IL-2 (females)
Cereals (refined grains): IL-6, IL-10 ↓ (all)
MUFA/SFA: IL-6 (all, females), sVCAM-1 (males), TGFβ-1 (females) ↑ sVCAM-1 (females)↓
Dairy: IL-1 (all, females), IL-5 (all, males), IL-6 (all, males, females), IL-10 (females), TGFβ-1 (females) ↑
Meat: IL-2 (females), IL-10 (all, females) ↑
↔ All other
Aslam et al. (2020)
(Greece) [68]		n = 1338
11.5 ± 0.7
51% female		NAFood GroupsFood group: Dairy productshs-CRP, IL-6↔ No associations reported
Cabral et al. (2018)
(Portugal) [69]		n = 991
13 years
54% female		NAFood groupsFood groups: vegetables, fruits, starchy, refined grains, whole-grains, dairy, seafood, meat, soft-drink, fast-food, sweets and pastryhs-CRPVegetables/legumes (higher intake): hs-CRP ↓ (obese only)
Gonzales-gil (2015)
(Europe) [63]		n = 6403
2519 aged 2–6 years
48% female
3884 aged 6–10 years
51% female		NAFood GroupsFood groups: vegetables, fruits, refined grains, whole-grains, milk, dairy (yoghurt and cheese), fish, meat, egg, drinks, processed foods/snack foods, added sugar—spreads/jam/honey hs-CRPVegetable (increased intake): hs-CRP (males and females) ↓
Refined grains (increased intake): hs-CRP (females) ↑
SSB (increased intake): hs-CRP (females) ↑
↔ All other
Hagin et al. (2017)
(USA) [65]		n = 86
12.6 years mean
43% female		Inflammatory Bowel Disease (69% with Crohns Disease)
Present		Food GroupsFood groups: vegetables, fruits, snacks (including potato chips, candy, cookies, etc)CRPVegetable intake: CRP ↓
↔ All other
Han et al. (2015)
(Puerto Rico) [67]		n = 678
10.5 ± 2.7
47% female		Asthma
Present		Food GroupsFood groups: vegetables, fruits, whole-grains, dairy, meat, fats/oils, sweets/soda/snacksIL-1B, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, INF-y, TNF-αVegetables: IL-17F ↓
Whole-grains: IL-17F ↓
Dairy: IL-17F ↑
Sweets/Soda/Snacks: IL-17F ↑
↔ All other
Holt et al. (2009)
(USA) [66]		n = 285
14.9 ± 1.23
46% female		NAFood Groups
Nutrients		Food Groups: vegetables, fruits, fruit juice, french-fried potatoes, legumes
Micronutrients: vitamin C, beta-carotene		hs-CRP, IL-6, TNF-αTotal vegetable and fruit: TNF-α, IL-6, ↓
Vegetable: TNF-α ↓
Fruit: hs-CRP ↓
Vitamin C: hs-CRP, IL-6 ↓
Beta-Carotene: IL-6 and TNF-α ↓
↔ All other
Hur et al. (2012)
(USA) [72]		n = 4928
15.5 ± 0.1
49% female		NAFood Groups
Nutrients		Food groups: whole-grains
CRPWhole-grain: CRP ↓ (females)
Kosova et al. (2012)
(USA) [74]		n = 4880
3–11 years
49% female		NAFood groupsFood groups: Sugar sweetened beverage intakeCRPSSB (high intake): CRP ↑ (males)
Navarro (2017) *
(Spain) [59]		n = 571
6.8 years
53% female		NAFood Groups
Nutrients		Food groups: vegetables, fruits
Macronutrients: fat, carbohydrate, protein, fibre
Micronutrients: Vitamins: A, E		hs-CRPHigh dietary intake:
Fruit and Vegetable: hs-CRP ↓ (female)
SFA, vitamins A, E: hs-CRP ↑ (female only)
Fibre: hs-CRP ↓ (female only)
↔ All other
Qureshi et al. (2009)
(USA) [64]		n = 4110
11.6 ± 3.3
50% female		NAFood Groups
Nutrients		Food groups: vegetables, fruits, whole-grains, refined grains, dairy, meat/other proteins including eggs
Macronutrients: fat, carbohydrate, protein, fibre		hs-CRPVegetables, refined grain (low intake): hs-CRP ↑
↔ All other
Sanjeevi et al. (2018) *
(USA) [60]		n = 136
12.7 ± 2.6
% female not reported		Type-1 Diabetes
Present		Food Groups
Nutrients
(Secondary analysis of a trial that aimed to increase intake of whole plant foods in experimental group)		Food groups: vegetables, fruits, whole-grains, dairy, meat, eggs, seafood, nuts and seeds, refined grains, sodium, added sugars
Macronutrients: fat (SFA)		CRP↔ No associations reported
Nutrients—Observational
Aeberli et al. (2006)
(Switzerland) [70]		n = 79
10.1 ± 2.1
46.83% female		Overweight/obese
Present		Nutrients
Food Groups		Macronutrients: fats (SFA, PUFA, MUFA, total fat), protein
Food Groups: meat intake		hs-CRP, IL-6Fat (Total fat, % energy as fat): hs-CRP ↑
↔ All other
Arya et al. (2005)
(India) [78]		n = 359
18 ± 2.3
13% female		NANutrientsMacronutrients: fat, carbohydrate, protein, fibreCRPSFA (high intake): CRP ↑
↔ All other
Au et al. (2012)
(USA) [80]		n = 148
10–12 years
% female unknown		Cardiometabolic Risk
Outcome		NutrientsMacronutrients: Fat (SFA, MUFA, PUFA), carbohydratehs-CRP, IL-6↔ No associations reported
de Sousa et al. (2017)
(Brazil) [89]		n = 52
14–19 years
100% male		NANutrientsMicronutrients: Dietary zincIL-1B, IL-6, TNF-α↔ No associations reported
del Mar Bibiloni (2013) *
(Spain) [39]		n = 219
14.9 ± 1.3
100% female		NANutrientsMacronutrients: fat (SFA, PUFA—linoleic acid, MUFA—oleic acid)
Micronutrients: beta-carotene, vitamins A, C, E, manganese, selenium, magnesium		hs-CRP, IL-6, PAI-1, TNF-α, Dietary intake of:
PUFA (linoleic acid): PAI-1 ↓
MUFA (oleic acid), vitamin E: Il-6 ↓
Magnesium: Il-6 ↑
↔ All other
Harris et al. (2019)
(Germany) [77]		n = 824
15.2 ± 0.3
53% female		NANutrientsMacronutrients: Fat (SFA)hs-CRPSFA: hs-CRP ↓ (males only)
Jaacks et al. (2014)
(USA) [82]		n = 1405
47.9 ± 43.2
50% female		Type-1 Diabetes
Present		NutrientsMacronutrients: Dietary FibreIl-6, CRP↔ No associations reported
Karampola et al. (2019) *
(Greece) [50]		n = 142
13.4 ± 1.46
% female not stated		Overweight/obese
Present		Nutrients
Food Groups 		Macronutrients: fat, carbohydrates, protein, fibre
Food groups: added sugars		hs-CRP↔ No associations reported
King et al. (2016)
(USA) [88]		n = 5007
6–17 years
47% female		NANutrientsMicronutrients: magnesiumCRPMagnesium (low intake): CRP ↑
Lin et al. (2014)
(Europe) [83]		n = 1804
14.7 ± 1.2
53% female		NANutrientsMacronutrients: fibre—total fibre, energy-adjusted fibre, water in/soluble fibre CRP↔ No associations reported
Miller et al. (2017)
(USA) [86]		n = 142
15.3 ± 0.1
66.43% female		Overweight/obese
Present		NutrientsMacronutrients: dietary fibre derived from dietary intake information: fat, carbohydrate, added sugars, protein, vegetable, fruit, wholegrains, legumes, refined grains, SSB, snack foods (sweet)IL-6, IL-8, monocyte chemoattractant protein-1 (MCP1), PAI-1, TNF-αTotal fibre: PAI-1 ↓
Insoluble fibre: PAI-1, MCP-1 ↑
↔ All other
Oldewage-Theron et al. (2016)
(South Africa) [79]		n = 232
6–18 years
51.29% female		NANutrientsMacronutrients: fat (PUFA, MUFA, SFA, TFA, linoleic acid)
Micronutrients: iron, zinc, magnesium, vitamin C, E 		hs-CRP↔ No associations reported
Parikh et al. (2012)
(USA) [85]		n = 559
14–18 years
49% female		NANutrientsMacronutrients: fibrehs-CRP,Fibre: hs-CRP (both genders) ↓
↔ All other
Prihaningtyas et al. (2019)
(Indonesia) [75]		n = 59
13–16 years
46% female		Obesity
Present		NutrientsMacronutrients: fat, carbohydrate, proteinhs-CRP↔ No associations reported
Swann et al. (2020)
(Australia) [84]		n = 621
17-years
53%		N/ANutrientsMacronutrient: fibrehs-CRP↔ No associations reported
Thomas et al. (2007)
(UK) [76]		n = 164
12–13 years
54% female		NANutrientsMacronutrients: fat (SFA)hs-CRP↔ No associations reported
Zhu et al. (2014)
(USA) [87]		n = 766
14–18 years
50% female		NANutrientsMicronutrients: dietary sodiumhs-CRP, ICAM-1, TNF-α Sodium intake: TNF-α ↑
↔ All other
BF—Brown Flax Seed; CRP—C-reactive protein; GF—Golden Flax Seed; hs-CRP—high sensitivity C-reactive protein; IL—Interleukin; IL-1—Interleukin-1; IL-10—Interleukin-10; IL-17A—Interleukin-17A; IL-17F—Interleukin-17F; IL-1b—Interleukin-1b; IL-2—Interleukin-2; IL-21—Interleukin-21; IL-22—Interleukin-22; IL-23—Interleukin-23; IL-25—Interleukin-25; IL-31—Interleukin-31; IL-33—Interleukin-33; IL-4—Interleukin-4; IL-5—Interleukin-5; IL-6—Interleukin-6; IL-B—Interleukin-B; INF-y—Interferon gamma; MCP-1—monocyte chemoattractant protein-1; MUFA—Monounsaturated Fatty Acids; NA—not applicable; PAI-1—Plasminogen activator inhibitor-1; PUFA—Polyunsaturated Fatty Acids; SAA—Serum amyloid-A; sE-selectin—Soluble E-selectin; SFA—Saturated Fatty Acids; sICAM—Soluble intercellular adhesion molecule; sICAM-1—Soluble intercellular adhesion molecule-1; SSB—Sugar Sweetened Beverage; sVCAM—Soluble Vascular Cell Adhesion Molecule; sVCAM-1—Soluble Vascular Cell Adhesion Molecule-1; TFA—Total Fatty Acids; TGFβ-1—Transforming growth factor beta 1; TNF-α—Tumour necrosis factor-alpha; *—study examines more than 1 category of dietary intake and appears in both Table 1 and Table 2.
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Bujtor, M.; Turner, A.I.; Torres, S.J.; Esteban-Gonzalo, L.; Pariante, C.M.; Borsini, A. Associations of Dietary Intake on Biological Markers of Inflammation in Children and Adolescents: A Systematic Review. Nutrients 2021, 13, 356. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13020356

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Bujtor M, Turner AI, Torres SJ, Esteban-Gonzalo L, Pariante CM, Borsini A. Associations of Dietary Intake on Biological Markers of Inflammation in Children and Adolescents: A Systematic Review. Nutrients. 2021; 13(2):356. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13020356

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Bujtor, Melissa, Anne I. Turner, Susan J. Torres, Laura Esteban-Gonzalo, Carmine M. Pariante, and Alessandra Borsini. 2021. "Associations of Dietary Intake on Biological Markers of Inflammation in Children and Adolescents: A Systematic Review" Nutrients 13, no. 2: 356. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13020356

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