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Article

Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese

1
Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
2
School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
3
Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing 100000, China
4
Key Laboratory of Systems Health Science of Zhejiang Province, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou 310024, China
*
Author to whom correspondence should be addressed.
Academic Editor: Hans-Peter Kubis
Received: 9 March 2021 / Revised: 20 April 2021 / Accepted: 23 April 2021 / Published: 27 April 2021
Little is known about changes in plasma metabolome profiles during the oral glucose tolerance test (OGTT) in Chinese. We aimed to characterize plasma metabolomic profiles at 0 and 2 h of OGTT and their changes in individuals of different glycemic statuses. A total of 544 metabolites were detected at 0 and 2 h of OGTT by a nontarget strategy in subjects with normal glucose (n = 234), prediabetes (n = 281), and newly diagnosed type 2 diabetes (T2D) (n = 66). Regression model, mixed model, and partial least squares discrimination analysis were applied. Compared with subjects of normal glucose, T2D cases had significantly higher levels of glycerone at 0 h and 22 metabolites at 2 h of OGTT (false discovery rate (FDR) < 0.05, variable importance in projection (VIP) > 1). Seven of the twenty-two metabolites were also significantly higher in T2D than in prediabetes subjects at 2 h of OGTT (FDR < 0.05, VIP > 1). Two hours after glucose challenge, concentrations of 35 metabolites (normal: 18; prediabetes: 23; T2D: 13) significantly increased (FDR < 0.05, VIP > 1, fold change (FC) > 1.2), whereas those of 45 metabolites (normal: 36; prediabetes: 29; T2D: 18) significantly decreased (FDR < 0.05, VIP > 1, FC < 0.8). Distinct responses between cases and noncases were detected in metabolites including 4-imidazolone-5-acetate and 4-methylene-L-glutamine. More varieties of distinct metabolites across glycemic statuses were observed at 2 h of OGTT compared with fasting state. Whether the different patterns and responsiveness of certain metabolites in T2D reflect a poor resilience of specific metabolic pathways in regaining glucose homeostasis merits further study. View Full-Text
Keywords: diabetes; oral glucose tolerance test; metabolome; dynamic change diabetes; oral glucose tolerance test; metabolome; dynamic change
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MDPI and ACS Style

Huo, S.; Sun, L.; Zong, G.; Shen, X.; Zheng, H.; Jin, Q.; Li, H.; Yin, H.; Lin, X. Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese. Nutrients 2021, 13, 1474. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13051474

AMA Style

Huo S, Sun L, Zong G, Shen X, Zheng H, Jin Q, Li H, Yin H, Lin X. Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese. Nutrients. 2021; 13(5):1474. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13051474

Chicago/Turabian Style

Huo, Shaofeng, Liang Sun, Geng Zong, Xia Shen, He Zheng, Qianlu Jin, Huaixing Li, Huiyong Yin, and Xu Lin. 2021. "Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese" Nutrients 13, no. 5: 1474. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13051474

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