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Article

Maternal DHA Supplementation during Pregnancy and Lactation in the Rat Protects the Offspring against High-Calorie Diet-Induced Hepatic Steatosis

1
UMR Physiologie des Adaptations Nutritionnelles, INRAE—Université de Nantes, 44096 Nantes, France
2
Medical and Psychology School, Autonomous University of Baja California, Tijuana 21100, Mexico
3
Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico
4
CRNH-O Mass Spectrometry Core Facility, 8 Quai Moncousu, 44000 Nantes, France
5
Université de Nantes, CNRS, INSERM, L’institut du Thorax, 8 Quai Moncousu, 44000 Nantes, France
6
Université de Nantes, CHU Nantes, Inserm, CNRS, SFR Santé, Inserm UMS 016, CNRS UMS 3556, 8 Quai Moncousu, 44000 Nantes, France
*
Author to whom correspondence should be addressed.
Academic Editor: Carlo Agostoni
Received: 6 August 2021 / Revised: 29 August 2021 / Accepted: 30 August 2021 / Published: 31 August 2021
(This article belongs to the Special Issue Early-Life Nutrition and Metabolic Disorders in Later Life)
Maternal supplementation during pregnancy with docosahexaenoic acid (DHA) is internationally recommended to avoid postpartum maternal depression in the mother and improve cognitive and neurological outcomes in the offspring. This study was aimed at determining whether this nutritional intervention, in the rat, protects the offspring against the development of obesity and its associated metabolic disorders. Pregnant Wistar rats received an extract of fish oil enriched in DHA or saline (SAL) as placebo by mouth from the beginning of gestation to the end of lactation. At weaning, pups were fed standard chow or a free-choice, high-fat, high-sugar (fc-HFHS) diet. Compared to animals fed standard chow, rats exposed to the fc-HFHS diet exhibited increased body weight, liver weight, body fat and leptin in serum independently of saline or DHA maternal supplementation. Nevertheless, maternal DHA supplementation prevented both the glucose intolerance and the rise in serum insulin resulting from consumption of the fc-HFHS diet. In addition, animals from the DHA-fc-HFHS diet group showed decreased hepatic triglyceride accumulation compared to SAL-fc-HFHS rats. The beneficial effects on glucose homeostasis declined with age in male rats. Yet, the preventive action against hepatic steatosis was still present in 6-month-old animals of both sexes and was associated with decreased hepatic expression of lipogenic genes. The results of the present work show that maternal DHA supplementation during pregnancy programs a healthy phenotype into the offspring that was protective against the deleterious effects of an obesogenic diet. View Full-Text
Keywords: developmental programming; DHA; obesity; hepatic steatosis developmental programming; DHA; obesity; hepatic steatosis
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MDPI and ACS Style

Daher-Abdi, A.; Olvera Hernández, S.; Reyes Castro, L.A.; Mezo-González, C.E.; Croyal, M.; García-Santillán, J.A.; Ouguerram, K.; Zambrano, E.; Bolaños-Jiménez, F. Maternal DHA Supplementation during Pregnancy and Lactation in the Rat Protects the Offspring against High-Calorie Diet-Induced Hepatic Steatosis. Nutrients 2021, 13, 3075. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093075

AMA Style

Daher-Abdi A, Olvera Hernández S, Reyes Castro LA, Mezo-González CE, Croyal M, García-Santillán JA, Ouguerram K, Zambrano E, Bolaños-Jiménez F. Maternal DHA Supplementation during Pregnancy and Lactation in the Rat Protects the Offspring against High-Calorie Diet-Induced Hepatic Steatosis. Nutrients. 2021; 13(9):3075. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093075

Chicago/Turabian Style

Daher-Abdi, Amran, Sandra Olvera Hernández, Luis A. Reyes Castro, Carla E. Mezo-González, Mikaël Croyal, Juan A. García-Santillán, Khadija Ouguerram, Elena Zambrano, and Francisco Bolaños-Jiménez. 2021. "Maternal DHA Supplementation during Pregnancy and Lactation in the Rat Protects the Offspring against High-Calorie Diet-Induced Hepatic Steatosis" Nutrients 13, no. 9: 3075. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093075

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