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Article

A Multi-Step miRNA-mRNA Regulatory Network Construction Approach Identifies Gene Signatures Associated with Endometrioid Endometrial Carcinoma

1
Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou 510515, China
2
Department of Pathology, the Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China
3
Department of Gynaecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Nora L. Nock
Received: 5 April 2016 / Revised: 16 May 2016 / Accepted: 24 May 2016 / Published: 2 June 2016
(This article belongs to the Section Human Genomics and Genetic Diseases)
We aimed to identify endometrioid endometrial carcinoma (EEC)-related gene signatures using a multi-step miRNA-mRNA regulatory network construction approach. Pathway analysis showed that 61 genes were enriched on many carcinoma-related pathways. Among the 14 highest scoring gene signatures, six genes had been previously shown to be endometrial carcinoma. By qRT-PCR and next generation sequencing, we found that a gene signature (CPEB1) was significantly down-regulated in EEC tissues, which may be caused by hsa-miR-183-5p up-regulation. In addition, our literature surveys suggested that CPEB1 may play an important role in EEC pathogenesis by regulating the EMT/p53 pathway. The miRNA-mRNA network is worthy of further investigation with respect to the regulatory mechanisms of miRNAs in EEC. CPEB1 appeared to be a tumor suppressor in EEC. Our results provided valuable guidance for the functional study at the cellular level, as well as the EEC mouse models. View Full-Text
Keywords: CPEB1; endometrial carcinoma; miRNA targets; protein-protein interaction network; EMT; p53 CPEB1; endometrial carcinoma; miRNA targets; protein-protein interaction network; EMT; p53
MDPI and ACS Style

Xiong, H.; Li, Q.; Chen, R.; Liu, S.; Lin, Q.; Xiong, Z.; Jiang, Q.; Guo, L. A Multi-Step miRNA-mRNA Regulatory Network Construction Approach Identifies Gene Signatures Associated with Endometrioid Endometrial Carcinoma. Genes 2016, 7, 26. https://0-doi-org.brum.beds.ac.uk/10.3390/genes7060026

AMA Style

Xiong H, Li Q, Chen R, Liu S, Lin Q, Xiong Z, Jiang Q, Guo L. A Multi-Step miRNA-mRNA Regulatory Network Construction Approach Identifies Gene Signatures Associated with Endometrioid Endometrial Carcinoma. Genes. 2016; 7(6):26. https://0-doi-org.brum.beds.ac.uk/10.3390/genes7060026

Chicago/Turabian Style

Xiong, Hanzhen, Qiulian Li, Ruichao Chen, Shaoyan Liu, Qiongyan Lin, Zhongtang Xiong, Qingping Jiang, and Linlang Guo. 2016. "A Multi-Step miRNA-mRNA Regulatory Network Construction Approach Identifies Gene Signatures Associated with Endometrioid Endometrial Carcinoma" Genes 7, no. 6: 26. https://0-doi-org.brum.beds.ac.uk/10.3390/genes7060026

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