Life, Volume 11, Issue 1 (January 2021) – 72 articles
Cover Story (view full-size image): The endoplasmic reticulum is the protein synthesis factory of the cells. ER stress and unfolded protein response (UPR) are key cellular responses against misfolded protein accumulation in the ER. UPR maintains cellular balance and potentially is involved in pathogenesis of many diseases, including idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary (COPD) disease. Both genetic and environmental factors might be involved in UPR-induced IPF and COPD. UPR triggers programmed cell death (apoptosis), epithelial-to-mesenchymal transition (EMT), fibrosis and inflammation and potentially initiates IPF and COPD. Targeting different arms of UPR could be a future therapeutic approach for developing new therapies for IPF and COPD and bring hope to these patients for better quality of life. View this paper.
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