Antibiotic Prophylaxis in the Prevention of Postoperative Infections in Mandibular Third Molar Extractions: Systematic Review and Meta-Analysis
, Giorgia Olivieri 1,†, Jessica Landini 1, Andrea Ferrigno 2, Plinio Richelmi 2, Claudia Todaro 1,‡ and Ruggero Rodriguez y Baena 1,‡Round 1
Reviewer 1 Report
In this study, the authors did systematic review and meta-analysis to evaluate the effectiveness of antibiotic prophylaxis for the prevention of surgical wound infection following mandibular third molar extraction. These are important and interesting area for clinical research of dentistry. This paper is well written and seems to be written according to the rules of systematic review. I have a comment.
I think that the author only lists the results in the discussion section. For example, the results showed that pre- and post-surgical and post-surgical antibiotic prophylaxis demonstrated lower efficiency than pre-surgical antibiotic prophylaxis alone. Many readers may want to know why pre-surgical antibiotic prophylaxis alone is higher than both pre- and post-surgical antibiotic prophylaxis. The authors should discuss more detail.
Author Response
Reviewer 1:
In this study, the authors did systematic review and meta-analysis to evaluate the effectiveness of antibiotic prophylaxis for the prevention of surgical wound infection following mandibular third molar extraction. These are important and interesting area for clinical research of dentistry. This paper is well written and seems to be written according to the rules of systematic review. I have a comment.
I think that the author only lists the results in the discussion section. For example, the results showed that pre- and post-surgical and post-surgical antibiotic prophylaxis demonstrated lower efficiency than pre-surgical antibiotic prophylaxis alone. Many readers may want to know why pre-surgical antibiotic prophylaxis alone is higher than both pre- and post-surgical antibiotic prophylaxis. The authors should discuss more detail.
Reply:
Dear reviewer, thank you for this comment. In fact, even to the authors this result seemed counterintuitive. The authors hypothesized that the administration of a double dose of antibiotic, typical of the preoperative modality, may explain the lower incidence of postoperative complications as it allows a maximum blood concentration during surgery. Lines 295 and following.
Reviewer 2 Report
The article is well written and scientifically sound.
Some minor issue should be improved.
The english language should be improved, and some form should be avoided (ex line184)
Considering this kind of analysis
Lo Giudice R, Puleio F, Rizzo D, Alibrandi A, Lo Giudice G, Centofanti A, et al. Comparative investigation of cutting devices on bone blocks: An SEM morphological analysis. Appl Sci 2019;9(2).
does the author thinks that the cutting device could influence the surgical outcome ?
Author Response
Reviewer 2:
The article is well written and scientifically sound.
Some minor issue should be improved.
- The english language should be improved, and some form should be avoided (ex line184)
Reply: Dear reviewer, thank you for this comment. The text has been completely revised and corrected.
- Considering this kind of analysis
Lo Giudice R, Puleio F, Rizzo D, Alibrandi A, Lo Giudice G, Centofanti A, et al. Comparative investigation of cutting devices on bone blocks: An SEM morphological analysis. Appl Sci 2019;9(2).
does the author thinks that the cutting device could influence the surgical outcome ?
Reply: Dear reviewer, thank you for this comment. Actually, we had not considered this aspect. We added it among the limitations of the work and we included the appropriate bibliographic reference.
