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Article

Facile In-Situ Fabrication of a Ternary ZnO/TiO2/Ag Nanocomposite for Enhanced Bactericidal and Biocompatibility Properties

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Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
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Centre for Foundation Studies in Science, University of Malaya, Kuala Lumpur 50603, Malaysia
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Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
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Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
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Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia
*
Author to whom correspondence should be addressed.
Received: 1 October 2020 / Revised: 14 December 2020 / Accepted: 29 December 2020 / Published: 18 January 2021
(This article belongs to the Special Issue Discovery and Functional Evaluation of Antimicrobials)
This paper presents for the first time a successful fabrication of ternary ZnO/TiO2/Ag nanocomposites consisting of zinc oxide (ZnO), titania (TiO2) and silver (Ag) nanoparticles (NPs) synthesised using Morinda citrifolia fruit (MCF) extract. ZnONPs were synthesised using the co-precipitation method, and TiO2 and Ag were introduced into the precursor solutions under microwave irradiation to obtain ZnO/TiO2/Ag nanocomposites (NCs). This material demonstrated enhanced bactericidal effect towards bacterial pathogens compared to that of the binary TiO2/Ag, Ag and TiO2 alone. In vitro cytotoxicity results of the as-synthesised ZnO/TiO2/AgNCs on RAW 264.7 macrophages and A549 cell lines revealed a negative role in cytotoxicity, but contributed astoundingly towards antimicrobials as compared of Ag alone and binary Ag/TiO2. This study shows that the resultant ternary metal/bi-semiconductor nanocomposites may provide a therapeutic strategy for the eradication of bacterial pathogens without affecting the healthy mammalian cells. View Full-Text
Keywords: antibacterial; semiconductor materials; nanocomposites; precipitation; cytotoxicity antibacterial; semiconductor materials; nanocomposites; precipitation; cytotoxicity
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MDPI and ACS Style

Sakthi Mohan, P.; Sonsuddin, F.; Mainal, A.B.; Yahya, R.; Venkatraman, G.; Vadivelu, J.; Al-Farraj, D.A.; Al-Mohaimeed, A.M.; Alarjani, K.M. Facile In-Situ Fabrication of a Ternary ZnO/TiO2/Ag Nanocomposite for Enhanced Bactericidal and Biocompatibility Properties. Antibiotics 2021, 10, 86. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10010086

AMA Style

Sakthi Mohan P, Sonsuddin F, Mainal AB, Yahya R, Venkatraman G, Vadivelu J, Al-Farraj DA, Al-Mohaimeed AM, Alarjani KM. Facile In-Situ Fabrication of a Ternary ZnO/TiO2/Ag Nanocomposite for Enhanced Bactericidal and Biocompatibility Properties. Antibiotics. 2021; 10(1):86. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10010086

Chicago/Turabian Style

Sakthi Mohan, Priyadarshini, Faridah Sonsuddin, Azizah B. Mainal, Rosiyah Yahya, Gopinath Venkatraman, Jamuna Vadivelu, Dunia A. Al-Farraj, Amal M. Al-Mohaimeed, and Khaloud M. Alarjani 2021. "Facile In-Situ Fabrication of a Ternary ZnO/TiO2/Ag Nanocomposite for Enhanced Bactericidal and Biocompatibility Properties" Antibiotics 10, no. 1: 86. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10010086

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