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Article

Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients

1
Department of Basic Medical Sciences, Neurosciences and Sense Organs, “Aldo Moro” University of Bari, 70122 Bari, Italy
2
Department of Emergency and Organ Transplantation, Division of Plastic and Reconstructive Surgery, “Aldo Moro” University of Bari, 70122 Bari, Italy
3
Ionian Department (DJSGEM), “Aldo Moro” University of Bari, 70122 Bari, Italy
4
Department of Dental and Maxillofacial Sciences, “Sapienza” University of Rome, 00100 Rome, Italy
5
Complex Operative Unit of Nephrology and Dialysis, Hospital S.S. Annunziata, 66100 Chieti, Italy
6
Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 10 October 2019 / Revised: 27 October 2019 / Accepted: 30 October 2019 / Published: 1 November 2019
(This article belongs to the Special Issue Sepsis: Pathophysiology, Diagnosis and Therapy)
Background: Malnutrition-inflammation complex syndrome (MICS) is a common and usually concurrent condition occurring in patients undergoing hemodialysis (HD), with a pathogenesis linked to biological and in situ environmental traditional risk factors. Periodontitis, one of the major types of infection-driven inflammation, often co-occurs in the in the hemodialysis population and correlates with markers of malnutrition and inflammation, such as albumin, creatinine, and C-reactive protein. Aim: The present study aimed to determine whether the periodontal inflammatory status parameters correlate with the albumin, creatinine, and C-reactive protein serum concentrations in HD patients, and investigate whether periodontal treatment improves these markers of nutritional and systemic inflammation. Materials and Methods: The serum creatinine, albumin, and C-reactive Protein (CRP) levels were measured at baseline and after non-surgical periodontal treatment, at 3 months and 6 months. Results: At 3 months, a significant correlation between plaque index and C-reactive protein (p = 0.012), bleeding on probing and C-reactive protein (p < 0.0019), and clinical attachment level and C-reactive protein (p = 0.022) was found. No significant correlation was found between clinical periodontal parameters and nutrition markers at each time. Conclusions: Our results confirmed the association between C-reactive protein serum concentration and periodontal inflammatory status, but further research is necessary to identify the contributing role of periodontitis on the onset and progression of MICS. View Full-Text
Keywords: periodontitis; inflammation; hemodialysis; C-reactive protein; creatinine; albumin periodontitis; inflammation; hemodialysis; C-reactive protein; creatinine; albumin
MDPI and ACS Style

Rapone, B.; Converti, I.; Santacroce, L.; Cesarano, F.; Vecchiet, F.; Cacchio, L.; Scacco, S.; Grassi, R.; Grassi, F.R.; Gnoni, A.; Ferrara, E.; Nardi, G.M. Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients. Antibiotics 2019, 8, 209. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8040209

AMA Style

Rapone B, Converti I, Santacroce L, Cesarano F, Vecchiet F, Cacchio L, Scacco S, Grassi R, Grassi FR, Gnoni A, Ferrara E, Nardi GM. Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients. Antibiotics. 2019; 8(4):209. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8040209

Chicago/Turabian Style

Rapone, Biagio, Ilaria Converti, Luigi Santacroce, Francesca Cesarano, Federico Vecchiet, Luciano Cacchio, Salvatore Scacco, Roberta Grassi, Felice R. Grassi, Antonio Gnoni, Elisabetta Ferrara, and Gianna M. Nardi 2019. "Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients" Antibiotics 8, no. 4: 209. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8040209

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