Special Issue "Sepsis: Pathophysiology, Diagnosis and Therapy"
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (10 December 2019).
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Sepsis is currently defined as the presence of a systemic inflammatory response syndrome (SIRS) in the setting of infection. Severe sepsis is defined as sepsis with evidence of end-organ dysfunction as a result of hypoperfusion, ultimately leading to septic shock and death if with persistent hypotension despite fluid resuscitation and resulting tissue hypoperfusion.
Mortality is still now up to 30%, and therapy requires an early detection of the causes of the infection and very good knowledge about its pathophysiology to prevent complications and death. During the last decade, a lot of data have been acquired about this issue, but antibiotic therapy still remains the backbone of the patients' treatment. On the other hand, during the last 20 years no new antibiotics have been invented, and the number of antibiotic resistant microrganisms is continuously increasing. So we need a new, updated diagnostic protocol including new biomarkers, and new therapies to lower the medical expenses and improve prognosis for septic patients.
Dr. Luigi Santacroce
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- gram negative bacteria
- antibiotic resitant microrganisms
- immune system
- immune response
- immune anergy
- microvascular thrombosis
- multiple organ dysfunction
- septic shock