Next Article in Journal
Ketone- and Cyano-Selenoesters to Overcome Efflux Pump, Quorum-Sensing, and Biofilm-Mediated Resistance
Next Article in Special Issue
Feasibility and Validity of a Framework for Antimicrobial Stewardship in General Practice: Key Stakeholder Interviews
Previous Article in Journal
Poly-ε-caprolactone Nanoparticles Loaded with 4-Nerolidylcatechol (4-NC) for Growth Inhibition of Microsporum canis
Previous Article in Special Issue
Impact and Sustainability of Antibiotic Stewardship in Pediatric Emergency Departments: Why Persistence Is the Key to Success
Open AccessReview

Are Follow-Up Blood Cultures Useful in the Antimicrobial Management of Gram Negative Bacteremia? A Reappraisal of Their Role Based on Current Knowledge

Department of Public Health and Infectious Diseases, University “Sapienza” of Rome, 00185 Rome, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to the paper.
Received: 6 November 2020 / Revised: 6 December 2020 / Accepted: 9 December 2020 / Published: 11 December 2020
(This article belongs to the Special Issue Antimicrobial Prescribing and Stewardship)
Bloodstream infections still constitute an outstanding cause of in-hospital morbidity and mortality, especially among critically ill patients. Follow up blood cultures (FUBCs) are widely recommended for proper management of Staphylococcus aureus and Candida spp. infections. On the other hand, their role is still a matter of controversy as far as Gram negative bacteremias are concerned. We revised, analyzed, and commented on the literature addressing this issue, to define the clinical settings in which the application of FUBCs could better reveal its value. The results of this review show that critically ill patients, endovascular and/or non-eradicable source of infection, isolation of a multi-drug resistant pathogen, end-stage renal disease, and immunodeficiencies are some factors that may predispose patients to persistent Gram negative bacteremia. An analysis of the different burdens that each of these factors have in this clinical setting allowed us to suggest which patients’ FUBCs have the potential to modify treatment choices, prompt an early source control, and finally, improve clinical outcome. View Full-Text
Keywords: follow-up blood cultures; Gram negative bacteremia; critically ill patients; antibiotic therapy follow-up blood cultures; Gram negative bacteremia; critically ill patients; antibiotic therapy
Show Figures

Figure 1

MDPI and ACS Style

Cogliati Dezza, F.; Curtolo, A.; Volpicelli, L.; Ceccarelli, G.; Oliva, A.; Venditti, M. Are Follow-Up Blood Cultures Useful in the Antimicrobial Management of Gram Negative Bacteremia? A Reappraisal of Their Role Based on Current Knowledge. Antibiotics 2020, 9, 895. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9120895

AMA Style

Cogliati Dezza F, Curtolo A, Volpicelli L, Ceccarelli G, Oliva A, Venditti M. Are Follow-Up Blood Cultures Useful in the Antimicrobial Management of Gram Negative Bacteremia? A Reappraisal of Their Role Based on Current Knowledge. Antibiotics. 2020; 9(12):895. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9120895

Chicago/Turabian Style

Cogliati Dezza, Francesco; Curtolo, Ambrogio; Volpicelli, Lorenzo; Ceccarelli, Giancarlo; Oliva, Alessandra; Venditti, Mario. 2020. "Are Follow-Up Blood Cultures Useful in the Antimicrobial Management of Gram Negative Bacteremia? A Reappraisal of Their Role Based on Current Knowledge" Antibiotics 9, no. 12: 895. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9120895

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop