Impact of the First COVID-19 Wave on French Hospitalizations for Myocardial Infarction and Stroke: A Retrospective Cohort Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Hospitalization Data
2.2. Study Design
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
List of Abbreviations
AF | atrial fibrillation |
ATIH | Agence Technique de l’Information sur l’Hospitalisation |
COVID-19 | Coronavirus Disease 2019 |
HS | hemorrhagic stroke |
ICD-10 | International Classification of Diseases-Tenth Revision |
IS | ischemic stroke |
LISA | Local Indicators of Spatial Association |
MI | myocardial infarction |
NSTEMI | Non-ST segment elevation myocardial infarction |
PMSI | Programme de Médicalisation des Systèmes d’Information |
STEMI | ST segment elevation myocardial elevation |
TIA | transient ischemic attack |
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COVID-19 + N (%) (n = 666) | COVID-19—N (%) (n = 13,536) | p-Value * | |
---|---|---|---|
All MI (n = 14,202) | |||
Age, years | |||
Mean (SD) | 73.0 (13.8) | 68.8 (14.1) | <0.0001 |
Sex | 0.10 | ||
Women | 235 (35.3) | 4367 (32.3) | |
Men | 431 (64.7) | 9169 (67.7) | |
Hypertension | 356 (53.5) | 5761 (42.6) | <0.0001 |
Diabetes | 212 (31.8) | 2993 (22.1) | <0.0001 |
Obesity | 94 (14.1) | 1582 (11.7) | 0.058 |
Atrial fibrillation | 169 (25.4) | 2014 (14.9) | <0.0001 |
In-hospital mortality | 183 (27.5) | 979 (7.2) | <0.0001 |
NSTEMI (n = 7323) | 327 | 6996 | |
Age, years | |||
Mean (SD) | 73.7 (13.6) | 70.3 (13.5) | <0.0001 |
Sex | 0.93 | ||
Women | 110 (33.6) | 2369 (33.9) | |
Men | 217 (66.4) | 4627 (66.1) | |
Hypertension | 201 (61.5) | 3387 (48.4) | <0.0001 |
Diabetes | 114 (34.9) | 1758 (25.1) | <0.0001 |
Obesity | 38 (11.6) | 834 (11.9) | 0.87 |
Atrial fibrillation | 88 (26.9) | 1091 (15.6) | <0.0001 |
In-hospital mortality | 72 (22.0) | 268 (3.8) | <0.0001 |
STEMI (n = 7663) | 387 | 7276 | |
Age, years | |||
Mean (SD) | 72.3 (13.7) | 67.4 (14.5) | <0.0001 |
Sex | 0.077 | ||
Women | 135 (34.9) | 2228 (30.6) | |
Men | 252 (65.1) | 5048 (69.4) | |
Hypertension | 183 (47.3) | 2762 (38.0) | 0.0002 |
Diabetes | 112 (28.9) | 1419 (19.5) | <0.0001 |
Obesity | 66 (17.1) | 854 (11.7) | 0.0017 |
Atrial fibrillation | 96 (24.8) | 1032 (14.2) | <0.0001 |
In-hospital mortality | 121 (31.3) | 753 (10.4) | <0.0001 |
COVID-19 + N (%) (n = 1361) | COVID-19—N (%) (n = 22,995) | p-Value * | |
---|---|---|---|
All stroke (n = 24,356) | |||
Age, years | |||
Mean (SD) | 73.9 (14.5) | 73.2 (14.8) | 0.090 |
Sex | <0.0001 | ||
Women | 566 (41.6) | 11,178 (48.6) | |
Men | 795 (58.4) | 11,817 (51.4) | |
Hypertension | 714 (52.5) | 11,552 (50.2) | 0.11 |
Diabetes | 351 (25.8) | 4274 (18.6) | <0.0001 |
Obesity | 139 (10.2) | 1734 (7.5) | 0.0003 |
Atrial fibrillation | 333 (24.5) | 5110 (22.2) | 0.053 |
In-hospital mortality | 424 (31.2) | 2811 (12.2) | <0.0001 |
Ischemic stroke (n = 15,411) | 914 | 14,497 | |
Age, years | |||
Mean (SD) | 74.4 (14.0) | 74.2 (14.3) | 0.76 |
Sex | <0.0001 | ||
Women | 371 (40.6) | 6869 (47.4) | |
Men | 543 (59.4) | 7628 (52.6) | |
Hypertension | 489 (53.5) | 7758 (53.5) | 0.99 |
Diabetes | 258 (28.2) | 3092 (21.3) | <0.0001 |
Obesity | 93 (10.2) | 1248 (8.6) | 0.10 |
Atrial fibrillation | 252 (27.6) | 3849 (26.6) | 0.50 |
In-hospital mortality | 274 (30.0) | 1602 (11.1) | <0.0001 |
Hemorrhagic stroke (n = 4892) | 335 | 4557 | |
Age, years | |||
Mean (SD) | 68.6 (15.2) | 70.7 (15.8) | 0.023 |
Sex | 0.0002 | ||
Women | 125 (37.3) | 2180 (47.8) | |
Men | 210 (62.7) | 2377 (52.2) | |
Hypertension | 157 (46.9) | 2191 (48.1) | 0.67 |
Diabetes | 74 (22.1) | 638 (14.0) | <0.0001 |
Obesity | 41 (12.2) | 321 (7.0) | 0·0005 |
Atrial fibrillation | 63 (18.8) | 949 (20.8) | 0.38 |
In-hospital mortality | 156 (46.6) | 1373 (30.1) | <0.0001 |
TIA (n = 5673) | 220 | 5453 | |
Age, years | |||
Mean (SD) | 77.8 (14.9) | 72.0 (14.7) | <0.0001 |
Sex | 0.43 | ||
Women | 108 (49.1) | 2826 (51.8) | |
Men | 112 (50.9) | 2627 (48.2) | |
Hypertension | 130 (59.1) | 2444 (44.8) | <0.0001 |
Diabetes | 47 (21.4) | 841 (15.4) | 0.017 |
Obesity | 16 (7.3) | 333 (6.1) | 0.48 |
Atrial fibrillation | 51 (23.2) | 753 (13.8) | <0.0001 |
In-hospital mortality | 31 (14.1) | 86 (1.6) | <0.0001 |
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Mariet, A.-S.; Duloquin, G.; Benzenine, E.; Roussot, A.; Pommier, T.; Eicher, J.-C.; Baptiste, L.; Giroud, M.; Cottin, Y.; Béjot, Y.; et al. Impact of the First COVID-19 Wave on French Hospitalizations for Myocardial Infarction and Stroke: A Retrospective Cohort Study. Biomedicines 2022, 10, 2501. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10102501
Mariet A-S, Duloquin G, Benzenine E, Roussot A, Pommier T, Eicher J-C, Baptiste L, Giroud M, Cottin Y, Béjot Y, et al. Impact of the First COVID-19 Wave on French Hospitalizations for Myocardial Infarction and Stroke: A Retrospective Cohort Study. Biomedicines. 2022; 10(10):2501. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10102501
Chicago/Turabian StyleMariet, Anne-Sophie, Gauthier Duloquin, Eric Benzenine, Adrien Roussot, Thibaut Pommier, Jean-Christophe Eicher, Laura Baptiste, Maurice Giroud, Yves Cottin, Yannick Béjot, and et al. 2022. "Impact of the First COVID-19 Wave on French Hospitalizations for Myocardial Infarction and Stroke: A Retrospective Cohort Study" Biomedicines 10, no. 10: 2501. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10102501