Effects of Treadmill Exercise on Neural Mitochondrial Functions in Parkinson’s Disease: A Systematic Review of Animal Studies
Abstract
:1. Introduction
2. Materials and Methods
2.1. Protocol and Registration
2.2. Eligibility Criteria
2.3. Information Sources and Search Strategy
2.4. Data Collection Process
2.5. Study Quality Evaluation
2.6. Data Synthesis and Presentation
3. Results
3.1. Search Results
3.2. Study Characteristics
3.3. Outcome Summary
3.3.1. Effects of TE Training on Neural Mitochondrial Respiratory Deficiency in PD
3.3.2. Effects of TE Training on Neural Mitochondrial Biogenesis in PD
3.3.3. Effects of TE Training on Neural Mitochondrial Dynamics in PD
3.3.4. Effects of TE Training on Neural Mitophagy in PD
3.4. Study Quality Evaluation
4. Discussion
4.1. Summary of Evidence
4.2. Study Quality Evaluation
4.3. Limitations
4.4. The Implications for Future Research
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Study | Model | Treadmill Exercise | Brain’s Tissue | Outcomes | |||
---|---|---|---|---|---|---|---|
Mitochondrial Respiratory Function | Mitochondrial Biogenesis | Mitochondrial Dynamic | Mitophagy | ||||
Koo and Cho, 2017 [20] | MPTP model on male mice (7-wk-old), induced by 25 mg/kg MPTP i.p, twice/wk for 5 wks | After PD induction. Duration: 40–60 min/day, 5 days/wk, 8 wks. Speed: 10–12 min/m. | Substantia Nigra Striatum | Compared to normal, protein levels of complex IV and cytochrome c were reduced in PD group. TE training enhanced those levels in PD. | Compared to normal, protein levels of SIRT1, PGC-1α, NRF-1, and TFAM were reduced in PD group. TE training enhanced those levels in PD. | Compared to normal, the protein levels of p62, beclin-1 levels, and LC3II/I ratio were increased in PD group. TE training reduced p62 levels, but unchanged beclin-1 and LC3II/I levels in PD. | |
Koo et al., 2017a [21] | MPTP model on male mice (7-wk-old) induced by 25 mg/kg MPTP i.p twice/wk for 5 wks | After PD induction. Duration: 40–60 min/day, 5 days/wk, 8 wks. Speed: 10–12 min/m. | Substantia Nigra Striatum | Compared to normal, protein levels of complex IV were reduced in PD group. TE training enhanced those levels in PD. | Compared to normal, protein levels of TOM-40, TOM-20, TIM-23, and mtHSP70 were reduced in PD group. TE training enhanced those levels in PD. | ||
Rezaee et al., 2019 [22] | 6-OHDA model on male rats (8-wk-old) induced by 2 μg/μL injected to the right medial forebrain bundle | Before PD induction. Duration: 25–50 min/day, 5 days/wk, 16 wks. Speed: 15–21 m/min. | Striatum | Compared to normal, both mRNA expression and protein levels of AMPK and PGC-1α were reduced in PD group. Both mRNA and protein levels of SIRT1 and TFAM were increased in PD group. All of those levels were enhanced by TE in PD group. | |||
Chuang et al., 2017 [15] | 6-OHDA model on female rats (8-wk-old) induced by 15 μg/μL injected to the ascending mesostriatal pathway | After PD induction. Duration: 30 min/day, 7 days/wk, 4 wks. Speed: 15 m/min. | Substantia Nigra Striatum | Compared to normal, protein levels of complex I was reduced, whereas complex II, III, IV protein levels were increased in PD. TE increased complex I levels and reduced complex II, III, IV levels in PD. Complex V protein levels were unchanged among three groups. | Compared to normal, protein levels of TOM-20 were reduced in PD group. TE training enhanced TOM-20 levels in PD in Substantia Nigra. TOM-20 level was unchanged among three groups in striatum. | Compared to normal, protein levels of OPA-1, MFN-2, and Drp1 were reduced in PD group. TE training enhanced those levels in PD. | Compared to normal, the protein levels of PINK1 were increased in PD group. TE training reduced those levels in PD |
Jang et al., 2018 [23] | MPTP model on male mice (7-wk-old) induced by 25 mg/kg MPTP i.p daily, 7 days | After PD induction. Duration: 60 min/day, 5 days/wk, 6 wks. Speed: 12 m/min. | Substantia Nigra | Compared to normal, protein levels of complex II and V were reduced in PD group. TE training enhanced complex II and V levels in PD. Complex I, III, IV protein levels were unchanged among all groups. | Compared to normal, protein levels of TFAM, NRF-1, and SIRT3 were reduced in PD group. TE training enhanced those levels in PD. PGC-1α protein level was unchanged among three groups. | Compared to normal, protein levels of OPA-1, MFN-2, and p-Drp1Ser637 were reduced in PD group. TE training enhanced those levels in PD. | |
Tuon et al., 2015 [16] | 6-OHDA model on male mice (8-wk-old) induced by 2 μg/μL injected to the striatum | Before PD induction. Duration: 50 min/day, 3–4 days/wk, 8 wks Speed: 13–17 m/min. | Striatum Hippocampus | Compared to normal, protein levels of SIRT1 were reduced in PD group. TE training enhanced those levels in PD. | |||
Patki and Lau, 2011 [24] | MPTP model on male mice (6–10 month-old) induced by 15 mg/kg MPTP, 10 doses, s.c., 5 wks | Before and after PD induction. Duration: 40 min/day, 5 days/wk, 18 wks. Speed: 15 m/min. | Striatum | Compared to normal, cytochrome c protein level in mitochondria was reduced in PD group. TE training enhanced those levels in PD. | Compared to normal, the mRNA levels of TFAM, PGC-1α were increased in PD group. TE training reduced those levels in PD to normal. | ||
Lau et al., 2011 [25] | MPTP model on male mice (6–10 month-old) induced by 15 mg/kg MPTP, s.c., 10 doses, 5 wks | Before and after PD induction. Duration: 40 min/day, 5 days/wk, 18 wks. Speed: 15 m/min. | Substantia Nigra Striatum | Compared to normal, the mitochondrial respiration stage 3–4, as well as ATP production, were reduced in PD group. TE training enhanced those levels in PD | |||
Ferreira et al., 2020 [26] | 6-OHDA model on male mice (2–3 month-old) induced by 6 μg/μL injected to the striatum | After PD induction Duration: 40 min/day, 3 days/wk, 1 or 4 wks Speed: 10 m/min. | Substantia Nigra Striatum | Compared to normal, the protein level of complex I was reduced in PD group. 4-week TE training enhanced complex I levels in PD. Complex II-V in substantia nigra and complex I-V levels in striatum were unchanged among all groups. | Compared to normal, the levels of PGC-1α, NRF-1, and TFAM were reduced in PD. Those levels significantly increased to normal after 4 weeks training in Substantia Nigra. Those levels in striatum were unchanged among all groups. | ||
Hwang et al., 2018 [27] | MPTP model on male mice (8 week-old) induced by 25 mg/kg MPTP, i.p, 10 doses, 5 wks | After PD induction. Duration: 20 min/day, 5 days/wk, 8 wks. Speed: 15 m/min. | Substantia Nigra | Compared to normal, the protein levels of PINK1, Parkin, p62, and LC3II/I ratio were increased in PD group. TE training reduced the levels of PINK1, parkin, and p62, but unchanged LC3II/I ratio in PD. Compared to normal, protein levels of LAMP2 and Cathepsin L were reduced in PD group. TE enhanced those levels in PD. |
Study | CAMARADES Checklist of Study Quality | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | Total | |
Koo and Cho, 2017 [20] | √ | √ | √ | √ | √ | √ | 6 | ||||
Koo et al., 2017a [21] | √ | √ | √ | √ | √ | √ | 6 | ||||
Rezaee et al., 2019 [22] | √ | √ | √ | √ | √ | √ | √ | 7 | |||
Chuang et al., 2017 [15] | √ | √ | √ | √ | √ | √ | √ | 7 | |||
Jang et al., 2018 [23] | √ | √ | √ | √ | √ | √ | 6 | ||||
Tuon et al., 2015 [16] | √ | √ | √ | √ | √ | √ | 7 | ||||
Patki and Lau, 2011 [24] | √ | √ | √ | √ | 4 | ||||||
Lau et al., 2011 [25] | √ | √ | √ | √ | 4 | ||||||
Ferreira et al., 2020 [26] | √ | √ | √ | √ | √ | 5 | |||||
Hwang et al., 2018 [27] | √ | √ | √ | √ | √ | 5 |
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Nhu, N.T.; Cheng, Y.-J.; Lee, S.-D. Effects of Treadmill Exercise on Neural Mitochondrial Functions in Parkinson’s Disease: A Systematic Review of Animal Studies. Biomedicines 2021, 9, 1011. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines9081011
Nhu NT, Cheng Y-J, Lee S-D. Effects of Treadmill Exercise on Neural Mitochondrial Functions in Parkinson’s Disease: A Systematic Review of Animal Studies. Biomedicines. 2021; 9(8):1011. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines9081011
Chicago/Turabian StyleNhu, Nguyen Thanh, Yu-Jung Cheng, and Shin-Da Lee. 2021. "Effects of Treadmill Exercise on Neural Mitochondrial Functions in Parkinson’s Disease: A Systematic Review of Animal Studies" Biomedicines 9, no. 8: 1011. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines9081011