Next Article in Journal
Reversal of Multidrug Resistance in Human Colon Cancer and Human Leukemia Cells by Three Plant Extracts and Their Major Secondary Metabolites
Next Article in Special Issue
Quercetin Enhances the Thioredoxin Production of Nasal Epithelial Cells In Vitro and In Vivo
Previous Article in Journal
The Phytochemistry of Cherokee Aromatic Medicinal Plants
Previous Article in Special Issue
Pathogenic Viruses Commonly Present in the Oral Cavity and Relevant Antiviral Compounds Derived from Natural Products
Review

The Biological Efficacy of Natural Products against Acute and Chronic Inflammatory Diseases in the Oral Region

1
Department of Dental Pharmacology, Matsumoto Dental University, 1780 Gobara Hirooka, Shiojiri 399-0781, Japan
2
Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan
3
Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8525, Japan
*
Author to whom correspondence should be addressed.
Received: 26 October 2018 / Revised: 8 November 2018 / Accepted: 8 November 2018 / Published: 13 November 2018
The oral inflammatory diseases are divided into two types: acute and chronic inflammatory diseases. In this review, we summarize the biological efficacy of herbal medicine, natural products, and their active ingredients against acute and chronic inflammatory diseases in the oral region, especially stomatitis and periodontitis. We review the effects of herbal medicines and a biscoclaurin alkaloid preparation, cepharamthin, as a therapy against stomatitis, an acute inflammatory disease. We also summarize the effects of herbal medicines and natural products against periodontitis, a chronic inflammatory disease, and one of its clinical conditions, alveolar bone resorption. Recent studies show that several herbal medicines such as kakkonto and ninjinto reduce LPS-induced PGE 2 production by human gingival fibroblasts. Among herbs constituting these herbal medicines, shokyo (Zingiberis Rhizoma) and kankyo (Zingiberis Processum Rhizoma) strongly reduce PGE 2 production. Moreover, anti-osteoclast activity has been observed in some natural products with anti-inflammatory effects used against rheumatoid arthritis such as carotenoids, flavonoids, limonoids, and polyphenols. These herbal medicines and natural products could be useful for treating oral inflammatory diseases. View Full-Text
Keywords: inflammatory disease; stomatitis; periodontitis; anti-osteoclast activity; cepharanthin; herbal medicine; natural product; arachidonic acid cascade inflammatory disease; stomatitis; periodontitis; anti-osteoclast activity; cepharanthin; herbal medicine; natural product; arachidonic acid cascade
Show Figures

Figure 1

MDPI and ACS Style

Ara, T.; Nakatani, S.; Kobata, K.; Sogawa, N.; Sogawa, C. The Biological Efficacy of Natural Products against Acute and Chronic Inflammatory Diseases in the Oral Region. Medicines 2018, 5, 122. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines5040122

AMA Style

Ara T, Nakatani S, Kobata K, Sogawa N, Sogawa C. The Biological Efficacy of Natural Products against Acute and Chronic Inflammatory Diseases in the Oral Region. Medicines. 2018; 5(4):122. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines5040122

Chicago/Turabian Style

Ara, Toshiaki, Sachie Nakatani, Kenji Kobata, Norio Sogawa, and Chiharu Sogawa. 2018. "The Biological Efficacy of Natural Products against Acute and Chronic Inflammatory Diseases in the Oral Region" Medicines 5, no. 4: 122. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines5040122

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop