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Open AccessArticle

Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis

1
Nemours Healthcare System for Children, Wilmington, DE 19803, USA
2
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
3
History of Science and Medicine Department, Yale University, New Haven, CT 06511, USA
4
Master of Public Health, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Davie, FL 33328, USA
5
Master of Public Health Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
*
Author to whom correspondence should be addressed.
Received: 27 October 2020 / Revised: 31 December 2020 / Accepted: 31 December 2020 / Published: 5 January 2021
(This article belongs to the Section Cancer Biology and Anticancer Therapeutics)
Helicobacter pylori (H. pylori) is a bacterial pathogen implicated in gastritis, gastric ulceration, and gastric carcinoma. This study aimed to synthesize literature in providing evidence on the causative role of H. pylori in gastric carcinoma development. This study is based on assessing public literature using an applied meta-analysis, namely, quantitative evidence synthesis (QES). The analytic procedure uses DerSimonian-Laird, including assessing heterogeneity. The QES also utilizes meta-regression and the environmental effect associated with H. pylori in gastric cancer development. Eighteen studies are included in the QES. There is increased prevalence of H. pylori exposure among the cases. The heterogeneity between the CES and individual effect sizes is also significant. Despite controlling for the confoundings, there is increased exposure to H. pylori among the gastric cancer cases, regardless of the differences in the geographic location. H. pylori in this synthesized literature illustrates the contributory role of this microbe in gastric carcinoma. Additionally, regardless of geographic locale, namely, South Korea or Spain, H. pylori is implicated in gastric cancer development. View Full-Text
Keywords: Helicobacter pylori (H. pylori); gastric carcinoma; gastritis; gastric ulceration; QES Helicobacter pylori (H. pylori); gastric carcinoma; gastritis; gastric ulceration; QES
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MDPI and ACS Style

Holmes, L., Jr.; Rios, J.; Berice, B.; Benson, J.; Bafford, N.; Parson, K.; Halloran, D. Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis. Medicines 2021, 8, 1. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8010001

AMA Style

Holmes L Jr., Rios J, Berice B, Benson J, Bafford N, Parson K, Halloran D. Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis. Medicines. 2021; 8(1):1. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8010001

Chicago/Turabian Style

Holmes, Laurens, Jr.; Rios, Jasmine; Berice, Betyna; Benson, Jacqueline; Bafford, Nastocia; Parson, Kadedrah; Halloran, Daniel. 2021. "Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis" Medicines 8, no. 1: 1. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8010001

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