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Endogenous Double-Stranded RNA
Review

The Role of LncRNAs in Translation

1
Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Istinye University, Istanbul 34010, Turkey
2
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Received: 4 January 2021 / Revised: 16 February 2021 / Accepted: 18 February 2021 / Published: 20 February 2021
Long non-coding RNAs (lncRNAs), a group of non-protein coding RNAs with lengths of more than 200 nucleotides, exert their effects by binding to DNA, mRNA, microRNA, and proteins and regulate gene expression at the transcriptional, post-transcriptional, translational, and post-translational levels. Depending on cellular location, lncRNAs are involved in a wide range of cellular functions, including chromatin modification, transcriptional activation, transcriptional interference, scaffolding and regulation of translational machinery. This review highlights recent studies on lncRNAs in the regulation of protein translation by modulating the translational factors (i.e, eIF4E, eIF4G, eIF4A, 4E-BP1, eEF5A) and signaling pathways involved in this process as wells as their potential roles as tumor suppressors or tumor promoters. View Full-Text
Keywords: non-coding RNAs; long non-coding RNAs; ncRNAs; translation; cancer non-coding RNAs; long non-coding RNAs; ncRNAs; translation; cancer
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MDPI and ACS Style

Karakas, D.; Ozpolat, B. The Role of LncRNAs in Translation. Non-Coding RNA 2021, 7, 16. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010016

AMA Style

Karakas D, Ozpolat B. The Role of LncRNAs in Translation. Non-Coding RNA. 2021; 7(1):16. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010016

Chicago/Turabian Style

Karakas, Didem, and Bulent Ozpolat. 2021. "The Role of LncRNAs in Translation" Non-Coding RNA 7, no. 1: 16. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010016

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