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Proceedings

Polyphenols from Thelesperma megapotamicum and Their Antioxidant and Neuroprotective Activities

Instituto de Química del Sur (INQUISUR), Universidad Nacional del Sur-CONICET, 8000 Bahía Blanca, Argentina
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Presented at the 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–5 December 2020; Available online: https://ecsoc-24.sciforum.net/.
Published: 14 December 2020
Polyphenols are attracting increasing attention in the discovery of useful agents for the treatment of neurodegenerative diseases. Thelesperma megapotamicum (Spreng.) Kuntze belongs to the family Asteraceae, which is known to have a high antioxidant capacity. The phytochemical investigation of T. megapotamicum revealed the presence of 1′-S-isobutyroxyeugenol isobutyrate, (1), lupeol, (2), 1′-S-acetoxyeugenol isobutyrate, (3), stigmasterol, (4), β-sitosterol, (5), eriodictyol, (6), luteolin, (7), and marein, (8), as major secondary metabolites. The neuroprotective activity of this species was studied by evaluating the inhibition in vitro of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and the antioxidant capacity of the sub-extracts and of the major metabolites isolated from them. The AChE and BChE inhibition were determined by Ellman’s method and the antioxidant activity by DPPH assay. The inhibitory activity against BChE and the antioxidant capacity of the polyphenols present in T. megapotamicum highlight this species as a promising source of active metabolites for the development of agents for the treatment of neurodegenerative diseases.
Keywords: Thelesperma megapotamicum; polyphenols; antioxidant activity; cholinesterase inhibitors Thelesperma megapotamicum; polyphenols; antioxidant activity; cholinesterase inhibitors
MDPI and ACS Style

Siben, B.A.; Castro, M.J.; Faraoni, M.B. Polyphenols from Thelesperma megapotamicum and Their Antioxidant and Neuroprotective Activities. Chem. Proc. 2021, 3, 122. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08393

AMA Style

Siben BA, Castro MJ, Faraoni MB. Polyphenols from Thelesperma megapotamicum and Their Antioxidant and Neuroprotective Activities. Chemistry Proceedings. 2021; 3(1):122. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08393

Chicago/Turabian Style

Siben, Braian Alberto, María Julia Castro, and María Belén Faraoni. 2021. "Polyphenols from Thelesperma megapotamicum and Their Antioxidant and Neuroprotective Activities" Chemistry Proceedings 3, no. 1: 122. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08393

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