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Volume 1, December

Hemato, Volume 1, Issue 1 (September 2020) – 7 articles

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Editorial
Change of Title: Bloods Becomes Hemato
Hemato 2020, 1(1), 35; https://0-doi-org.brum.beds.ac.uk/10.3390/hemato1010007 - 23 Sep 2020
Viewed by 604
Abstract
Since January 2020, when the journal Bloods—the International Open Access Journal of Hematology—was founded, we have published six papers [...] Full article
Article
Doxorubicin Enhances Procoagulant Activity of Endothelial Cells after Exposure to Tumour Microparticles on Microfluidic Devices
Hemato 2020, 1(1), 23-34; https://0-doi-org.brum.beds.ac.uk/10.3390/bloods1010006 - 23 Jul 2020
Viewed by 1437
Abstract
The majority of cancer patients undergoing chemotherapy have a significantly increased risk of venous thromboembolism via a mechanism not yet fully elucidated but which most probably involves tumour microparticles (MP) combined with damaged/activated endothelium. Tumour cell lines (ES-2 and U87) were cultured as [...] Read more.
The majority of cancer patients undergoing chemotherapy have a significantly increased risk of venous thromboembolism via a mechanism not yet fully elucidated but which most probably involves tumour microparticles (MP) combined with damaged/activated endothelium. Tumour cell lines (ES-2 and U87) were cultured as 3D spheroids and transferred to biochips connected through to a second chip precultured with an endothelial cell layer (human umbilical vein endothelial cells [HUVECs]). Media were introduced with and without doxorubicin (DOX) to the spheroids in parallel chips under constant flow conditions. Media samples collected pre- and post-flow through the biochip were analysed for tissue factor microparticles (TFMP) and procoagulant activity (PCA). HUVECs were also harvested and tested for PCA at a constant cell number. TFMP levels in media decreased after passing over HUVECs in both conditions over time and this was accompanied by a reduction in PCA (indicated by a slower coagulation time) of the media. The relationship between PCA and TFMP was correlated (r = −0.85) and consistent across experiments. Harvested HUVECs displayed increased PCA when exposed to tumour spheroid media containing TFMP, which was increased further after the addition of DOX, suggesting that the TFMP in the media had bound to HUVEC cell surfaces. The enhanced PCA of HUVECs associated with the DOX treatment was attributed to a loss of viability of these cells rather than additional MP binding. The data suggest that tumour MP interact with HUVECs through ligand-receptor binding. The model described is a robust and reproducible method to investigate cytotoxic agents on tumour spheroids and subsequent downstream interaction with endothelial cells. Full article
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Editorial
Recent Advancements in Hematology: Knowledge, Methods and Dissemination, Part 1
Hemato 2020, 1(1), 10-22; https://0-doi-org.brum.beds.ac.uk/10.3390/bloods1010005 - 01 Jul 2020
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Abstract
Recent Advancements in Hematology: Knowledge, Methods and Dissemination is a series of editorials which is published on a biannual basis by the editorial board of the journal Bloods [...] Full article
(This article belongs to the Collection Exclusive Papers of the Editorial Board Members (EBMs) of Hemato)
Editorial
Classification of Tumors of the Hematopoietic and Lymphoid Tissues. Discovering Diseases—Defining Their Features
Hemato 2020, 1(1), 7-9; https://0-doi-org.brum.beds.ac.uk/10.3390/bloods1010004 - 13 May 2020
Viewed by 1232
Abstract
The World Health Organization (WHO) Classification of Tumours of the Hematopoietic and Lymphoid Tissues [...] Full article
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Editorial
Recent Advancements in Hematology: Knowledge, Methods and Dissemination
Hemato 2020, 1(1), 5-6; https://0-doi-org.brum.beds.ac.uk/10.3390/bloods1010003 - 20 Mar 2020
Viewed by 1247
Abstract
Communication in the field of biomedical research today involves professionals of numerous backgrounds, including researchers, doctors, public administrators, politicians, and health journalists [...] Full article
(This article belongs to the Collection Exclusive Papers of the Editorial Board Members (EBMs) of Hemato)
Editorial
Welcome to Bloods—An International Open Access Journal
Hemato 2020, 1(1), 3-4; https://0-doi-org.brum.beds.ac.uk/10.3390/bloods1010002 - 21 Feb 2020
Viewed by 928
Abstract
Hematologists, hematopathologists, cellular biologists, immunologists, and molecular biologists are invited to contribute to Bloods, a new international multidisciplinary journal for clinicians and experimental researchers of neoplastic and non-neoplastic blood diseases [...] Full article
Editorial
Bloods—An Open Access Journal of Hematology
Hemato 2020, 1(1), 1-2; https://0-doi-org.brum.beds.ac.uk/10.3390/bloods1010001 - 20 Feb 2020
Viewed by 1212
Abstract
MDPI has been publishing several medical journals, including the International Journal of Neonatal Screening [...] Full article
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