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Animals
Special Issues
Strategies to Improve Gut Health and Immunity in Monogastric Animals
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Strategies to Improve Gut Health and Immunity in Monogastric Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Nutrition".

Deadline for manuscript submissions: 15 December 2024 | Viewed by 1076

Special Issue Editors

Prof. Dr. Anna Czech

E-Mail Website
Guest Editor
Department of Biochemistry and Toxicology, University of Life Sciences in Lublin, Lublin, Poland
Interests: feed components; feed additives; monogastric animal nutrition; probiotics; prebiotics; ferments; production parameters; digestibility; body immunity parameters; antioxidant parameters; biochemical parameters
Special Issues, Collections and Topics in MDPI journals
Dr. Justyna Batkowska

E-Mail Website
Guest Editor
Institute of Biological Basis of Animal Production, University of Life Sciences in Lublin, ul. Akademicka 13, 20-950 Lublin, Poland
Interests: poultry; rearing systems; meat quality; eggs quality; hatching eggs; feed additives; bioactive compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Maintaining the gut health of animals is critical in livestock farming. This is extremely important, especially in young animals (weaning piglets, chicks), which are extremely susceptible to pathogens from various sources (rearing environment, diet, veterinary prophylaxis, the health status of the parental stock, etc.). For many years, research has been conducted on improving the intestinal health and immunity of animals. Many research directions of experiments have been considered, starting from zoohygienic procedures (temperature, humidity, ventilation, bedding additives) and the use of feed additives and supplements (i.e., probiotics, prebiotics, phytobiotics, etc.) and ending with interference in animal genetics. Providing breeding animals with conditions that have a positive impact on their gut anatomical structure (crypts, villi), increasing the absorption surface and/or microbiome, i.e., the development of beneficial intestinal micro-flora and limiting the spread of pathogens, brings many benefits, including, among others, improving digestibility, nutrient absorption, and the integrity of the intestinal barrier or stimulation of mucosal immunity.

This Special Issue, “Strategies to Improve Gut Health and Immunity in Monogastric Animals”, welcomes the submission of original research papers and reviews concerning all aspects related to optimizing the gut health of monogastric animals.

Prof. Dr. Anna Czech
Prof. Dr. Justyna Batkowska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut
  • immunity
  • health
  • microbiome
  • monogastric animals

Published Papers (1 paper)

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Research

11 pages, 253 KiB  
Article
Dietary Zn Deficiency Inhibits Cell Proliferation via the GPR39-Mediated Suppression of the PI3K/AKT/mTOR Signaling Pathway in the Jejunum of Broilers
by Yangyang Hu, Ke Yang, Weiyun Zhang, Mengxiao Xue, Tingting Li, Shengchen Wang, Xiaoyan Cui, Liyang Zhang, Yun Hu and Xugang Luo
Animals 2024, 14(6), 979; https://0-doi-org.brum.beds.ac.uk/10.3390/ani14060979 - 21 Mar 2024
Viewed by 578
Abstract
A prior investigation revealed that a lack of Zinc (Zn) could hinder intestinal cell proliferation in broiler chickens; however, the mechanisms responsible for this effect remain unclear. We aimed to investigate the possible mechanisms of dietary Zn deficiency in inhibiting the jejunal cell [...] Read more.
A prior investigation revealed that a lack of Zinc (Zn) could hinder intestinal cell proliferation in broiler chickens; however, the mechanisms responsible for this effect remain unclear. We aimed to investigate the possible mechanisms of dietary Zn deficiency in inhibiting the jejunal cell proliferation of broilers. For this study, a total of 112 chickens (21 days old) were randomly divided into two treatments (seven replicate cages per treatment, eight chickens per replicate cage): the control group (CON) and the Zn deficiency group. The duration of feeding was 21 d. Chickens in the control group were provided with a basal diet containing an extra addition of 40 mg Zn/kg in the form of Zn sulfate, whereas chickens in the Zn deficiency group were given the basal diet with no Zn supplementation. The results indicated that, in comparison to the CON, Zn deficiency increased (p < 0.05) the duodenal and jejunal crypt depth (CD) of broilers on d 28 and jejunal and ileal CD on d 35, and decreased (p < 0.05) the duodenal, jejunal, and ileal villus height/crypt depth (VH/CD) on d 28 and the jejunal VH, jejunal and ileal villus surface area, and VH/CD on d 35. Furthermore, Zn deficiency decreased (p < 0.0001) the number of proliferating cell nuclear antigen-positive cells and downregulated (p < 0.01) the mRNA or protein expression levels of phosphatidylinositol 3-kinase (PI3K), phosphorylated PI3K, phosphorylated serine–threonine kinase (AKT), phosphorylated mechanistic target of rapamycin (mTOR), G protein-coupled receptor 39 (GPR39), and extracellular-regulated protein kinase, but upregulated (p < 0.05) the mRNA or protein expression levels of P38 mitogen-activated protein kinase, c-jun N-terminal kinase (JNK) 1 and JNK2, and phosphorylated protein kinase C in the jejunum of the broilers on d 42. It was concluded that dietary Zn deficiency inhibited cell proliferation possibly via the GPR39-mediated suppression of the PI3K/AKT/mTOR signaling pathway in the jejunum of broilers. Full article
(This article belongs to the Special Issue Strategies to Improve Gut Health and Immunity in Monogastric Animals)
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