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Animals
Special Issues
Recent Advances in Intestinal Mucin Research
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Recent Advances in Intestinal Mucin Research

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Nutrition".

Deadline for manuscript submissions: closed (20 July 2022) | Viewed by 6935

Special Issue Editors

Dr. Marcin Barszcz

E-Mail Website
Guest Editor
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland
Interests: nutrition; pigs; poultry; rats; gut health; intestinal immunity; microbiota activity; bioactive compounds; probiotics; prebiotics
Dr. Anna Tus̈nio

E-Mail Website
Guest Editor
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland
Interests: pigs; chickens; rats; nutrition; feed additives; bioactive substances; legumes; potato protein; fibre; gastrointestinal tract; large intestine; fermentation bacterial enzymes
Dr. Ewa Święch

E-Mail Website
Guest Editor
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland
Interests: pigs; mucin; goblet cells; gastrointestinal tract; amino acids; dietary fiber; digestibility

Special Issue Information

Dear Colleagues,

Mucins are the main component of mucus, and are responsible for its protective functions, and thus contribute considerably to gut health. They are high-molecular-weight glycoproteins encoded by many mucin genes, the expression of which can be affected by nutrients and microbial metabolites. Mucus formed by different types of mucins covers the absorptive area and constitutes a physical barrier for pathogens and other detrimental factors. Thus, it is an important component of the innate immunity. It also provides an environment for the intestinal microbiota. The mucus layer undergoes permanent degradation and renewal, and changes in its properties may affect the absorption of nutrients, endogenous macromolecules, and ions.

Owing to the importance of mucins for gut health, many studies have been performed on livestock and laboratory animals. However, there are still many aspects that require further research or remain unknowns.

The aim of this Special Issue is to improve our knowledge in the field of intestinal mucins and protective mucus layer in livestock and laboratory animals. Therefore, we invite high-quality original research providing new insights on this topic, including the effects of nutritional factors on goblet cell count and their physiology, mucin concentration, mucin gene expression, mucolytic activity of microbiota, the relationship between microbial metabolites and mucus layer thickness, and others. Submissions focusing on in vitro studies using intestinal cell lines, as well as new methods used for mucin-related studies, are also welcomed.

Dr. Marcin Barszcz
Dr. Anna Tus̈nio
Prof. Ewa Święch
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mucus layer
  • mucin
  • goblet cells
  • gene expression
  • microbiota
  • nutrition
  • intestinal barrier
  • gut health

Published Papers (2 papers)

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Research

14 pages, 277 KiB  
Article
Modulation of Mucin Secretion in the Gut of Young Pigs by Dietary Threonine and Non-Essential Amino Acid Levels
by Ewa Święch, Anna Tuśnio, Marcin Taciak and Marcin Barszcz
Animals 2022, 12(3), 270; https://0-doi-org.brum.beds.ac.uk/10.3390/ani12030270 - 22 Jan 2022
Cited by 3 | Viewed by 2083
Abstract
The aim of the study was to determine the effect of threonine (Thr) and non-essential amino acid (NEAA) levels on mucin secretion and sugar composition of digesta and crude mucin preparations analyzed in different segments of the gut in young pigs. A two-factorial [...] Read more.
The aim of the study was to determine the effect of threonine (Thr) and non-essential amino acid (NEAA) levels on mucin secretion and sugar composition of digesta and crude mucin preparations analyzed in different segments of the gut in young pigs. A two-factorial experiment was conducted on 72 pigs using the following factors: Thr level (5.1, 5.7, 6.3 and 6.9 g standardized ileal digestible(SID) Thr/kg) and wheat gluten (WG) level used as a source of NEAA (20.4, 40.4 and 60.4 g WG protein in WG20, WG40 and WG60 diets, respectively). Mucin content was affected only by WG level. Tissue mucin content in the duodenum was higher in WG60 pigs than in WG20 and WG40 pigs, whereas in the middle jejunum was higher in WG40 and WG60 pigs than in WG20 pigs. In contrast, luminal crude mucin content in the proximal colon was lower in WG60 pigs compared to WG40 pigs. The lowest and highest Thr levels reduced arabinose and xylose contents and increased glucose content in ileal digesta. The highest WG level reduced arabinose and xylose contents and increased glucose content in ileal digesta. The lowest WG level increased mannose content in ileal digesta. WG60 level decreased the content of arabinose and galactose compared to lower WG levels in colonic digesta. Arabinose content was higher, while glucose and galactose contents were lower in crude mucin preparations isolated from colonic digesta in pigs fed diets containing the highest Thr level. The content of tissue mucin was higher in the ileum and proximal colon and lower in the duodenum than in the middle jejunum, whereas luminal mucin content was lower in the proximal colon than in the ileum. Ileal digesta contained less arabinose and glucose and more galactose as compared to colonic digesta. In conclusion, no effect of dietary Thr levels on mucin secretion in the gut of young pigs was found. Wheat gluten added to the diet with adequate Thr content positively affected mucin secretion only in the duodenum and middle jejunum. Full article
(This article belongs to the Special Issue Recent Advances in Intestinal Mucin Research)
12 pages, 1259 KiB  
Article
Growth Performance, Biochemical Blood Indices, and Large Intestine Physiology of Rats Fed Diets with Alfalfa Protein-Xanthophyll Concentrate
by Marcin Barszcz, Anna Tuśnio, Ilona Bachanek-Matusiewicz, Kamil Gawin, Jacek Skomiał and Marcin Taciak
Animals 2021, 11(7), 2069; https://0-doi-org.brum.beds.ac.uk/10.3390/ani11072069 - 12 Jul 2021
Cited by 2 | Viewed by 3381
Abstract
The effect of dietary levels of alfalfa protein-xanthophyll concentrate (PXC) was determined in growing rats. Three groups of eight four-week-old male Wistar rats, with an average initial body weight of 61 g, were fed for 28 days either natural-ingredient diets without PXC or [...] Read more.
The effect of dietary levels of alfalfa protein-xanthophyll concentrate (PXC) was determined in growing rats. Three groups of eight four-week-old male Wistar rats, with an average initial body weight of 61 g, were fed for 28 days either natural-ingredient diets without PXC or supplemented with 1.5% or 3% PXC. Growth performance, blood biochemistry, caecal fermentation, morphology of the large intestine, and mucin gene expression were evaluated. PXC did not affect growth performance but tended to decrease relative liver weight. Among biochemical blood parameters, only bilirubin decreased and uric acid increased in response to 1.5% and 3% PXC, respectively. Caecal fermentation was not affected, with the exception of isovaleric acid concentration, which tended to be higher in rats fed the diet containing 3% PXC. Colonic crypts tended to be deeper in rats fed the 3% PXC diet and the thickness of the colonic mucus layer was reduced by both PXC levels. In conclusion, PXC did not affect growth performance or caecal fermentation but decreased thickness of the protective mucus layer in the colon. Full article
(This article belongs to the Special Issue Recent Advances in Intestinal Mucin Research)
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