Maternal Nutrition and Offspring Programming: Impact on Animal Production and Performance

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Nutrition".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 8876

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Guest Editor
Nutrigenomics and Growth Biology Laboratory, Washington State University, Pullman, WA 99164, USA
Interests: meat science and muscle biology; developmental biology; nutrition and animal production

Special Issue Information

Dear Colleagues, 

The fetal period is very important for the development of animals, because all organs and tissues are rapidly formed and developed at this stage, undergoing further growth and maturation after birth. Developing tissues and organs are most sensitive to changes in the external environment, including maternal malnutrition, which leads to poor embryonic development and limits the long-term growth performance of animals. In the early embryonic stage, both muscle cells and fat cells are developed from the mesoderm, and their common origin provides an opportunity to strengthen muscle growth instead of adipogenic differentiation, thereby enhancing the lean/fat ratio of offspring. The initial formation of muscle fibers begins at the embryonic stage and continues to the fetal stage, and then muscle growth is mainly characterized by the hypertrophy of existing muscle fibers, in which muscle satellite cells play a key role. Therefore, increasing the number of muscle fibers and satellite cell density are two key control points for promoting muscle development and enhancing lean/fat ratio. The development of fat occurs slightly later than muscle fibers during fetal development; compared to other fat depots, intramuscular adipocyte formation occurs later and continues to around weaning, which provides an opportunity to specifically promote the development of intramuscular adipocytes and marbling fat accumulation. Understanding of mechanisms linking maternal nutrition to fetal development and offspring growth performance allows us to precisely manage animals to enhance production efficiency and quality. In this issue, a number of prominent researchers working on fetal developmental programming contribute research or review articles, with the objective to provide current status and updates in fetal programming research in livestock production.

Prof. Dr. Min Du
Guest Editor

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Keywords

  • gestation
  • meat
  • fetal programming
  • animal production
  • nutrition
  • quality

Published Papers (3 papers)

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Research

18 pages, 1971 KiB  
Article
Effect of Maternal Catalase Supplementation on Reproductive Performance, Antioxidant Activity and Mineral Transport in Sows and Piglets
by Guanglun Guo, Tiantian Zhou, Fengyun Ren, Jingzhan Sun, Dun Deng, Xingguo Huang, Teketay Wassie, Izhar Hyder Qazi and Xin Wu
Animals 2022, 12(7), 828; https://0-doi-org.brum.beds.ac.uk/10.3390/ani12070828 - 24 Mar 2022
Cited by 7 | Viewed by 2604
Abstract
This experiment was conducted to investigate the effects of maternal catalase (CAT) supplementation on reproductive performance, antioxidant enzyme activities, mineral transport, and mRNA expression of related genes in sows and offspring. A total of 40 pregnant sows at 95 days of gestation with [...] Read more.
This experiment was conducted to investigate the effects of maternal catalase (CAT) supplementation on reproductive performance, antioxidant enzyme activities, mineral transport, and mRNA expression of related genes in sows and offspring. A total of 40 pregnant sows at 95 days of gestation with similar parity (3–5 parities) and back-fat thickness were assigned randomly and equally into the control (CON) group (fed a basal diet) and CAT group (fed a basal diet supplemented with 660 mg/kg CAT; CAT activity, 280 U/g). The reproductive performance was recorded, and the placenta and blood samples of sows and neonatal piglets, as well as the jejunum and ileum samples from neonatal boars (eight replicates per group), were collected. Results showed that dietary supplementation with CAT significantly decreased the intrauterine growth restriction (IUGR) rate and increased the activity of serum CAT in neonatal piglets and umbilical cords (p < 0.05). In addition, CAT supplementation tended to improve total antioxidant capacity (T-AOC) levels in the maternal serum (p = 0.089) and umbilical cords of piglets (p = 0.051). The serum calcium (Ca), manganese (Mn), and zinc (Zn) of farrowing sows and Mn concentration in the umbilical cord, and serum Ca, magnesium (Mg), copper (Cu), and Mn of neonatal piglets were significantly increased (p < 0.05) in the CAT group. CAT supplementation downregulated mRNA expression of TRPV6 and CTR1 (p < 0.05), Cu/Zn SOD (p = 0.086) in the placenta and tended to increase the mRNA expression of the glutathione peroxidase 1 (GPX1) (p = 0.084), glutathione peroxidase 4 (GPX4) (p = 0.063), and CAT (p = 0.052) genes in the ileum of piglets. These results showed that the maternal CAT supplementation improved fetal growth by decreasing the IUGR rate, and modulated antioxidant activity, as well as mineral elements in the pregnant sows and their piglets. Full article
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11 pages, 261 KiB  
Article
Influence of Maternal Protein Restriction in Primiparous Beef Heifers during Mid- and/or Late-Gestation on Progeny Feedlot Performance and Carcass Characteristics
by Janna J. Block, Megan J. Webb, Keith R. Underwood, Michael G. Gonda, Adele A. Harty, Robin R. Salverson, Rick N. Funston, Kenneth C. Olson and Amanda D. Blair
Animals 2022, 12(5), 588; https://0-doi-org.brum.beds.ac.uk/10.3390/ani12050588 - 25 Feb 2022
Cited by 3 | Viewed by 1610
Abstract
This study investigated the impacts of metabolizable protein (MP) restriction in primiparous heifers during mid- and/or late-gestation on progeny performance and carcass characteristics. Heifers were allocated to 12 pens in a randomized complete block design. The factorial treatment structure included two stages of [...] Read more.
This study investigated the impacts of metabolizable protein (MP) restriction in primiparous heifers during mid- and/or late-gestation on progeny performance and carcass characteristics. Heifers were allocated to 12 pens in a randomized complete block design. The factorial treatment structure included two stages of gestation (mid- and late-) and two levels of dietary protein (control (CON); ~101% of MP requirements and restricted (RES); ~80% of MP requirements). Half of the pens on each treatment were randomly reassigned to the other treatment at the end of mid-gestation. Progeny were finished in a GrowSafe feeding system and carcass measurements were collected. Gestation treatment x time interactions indicated that MP restriction negatively influenced heifer body weight (BW), body condition score, and longissimus muscle (LM) area (p < 0.05), but not fat thickness (p > 0.05). Treatment did not affect the feeding period, initial or final BW, dry matter intake, or average daily gain of progeny (p > 0.05). The progeny of dams on the RES treatment in late gestation had a greater LM area (p = 0.04), but not when adjusted on a hot carcass weight basis (p > 0.10). Minimal differences in the animal performance and carcass characteristics suggest that the level of MP restriction imposed during mid- and late-gestation in this study did not have a significant developmental programming effect. Full article
14 pages, 1157 KiB  
Article
Skeletal Muscle Development in Postnatal Beef Cattle Resulting from Maternal Protein Restriction during Mid-Gestation
by Thais Correia Costa, Min Du, Karolina Batista Nascimento, Matheus Castilho Galvão, Javier Andrés Moreno Meneses, Erica Beatriz Schultz, Mateus Pies Gionbelli and Marcio de Souza Duarte
Animals 2021, 11(3), 860; https://0-doi-org.brum.beds.ac.uk/10.3390/ani11030860 - 18 Mar 2021
Cited by 24 | Viewed by 3778
Abstract
We aimed to investigate the effects of maternal protein restriction during mid-gestation on the skeletal muscle composition of the offspring. In the restriction treatment (RES, n = 9), cows were fed a basal diet, while in the control (CON, n = 9) group [...] Read more.
We aimed to investigate the effects of maternal protein restriction during mid-gestation on the skeletal muscle composition of the offspring. In the restriction treatment (RES, n = 9), cows were fed a basal diet, while in the control (CON, n = 9) group cows received the same RES diet plus the protein supplement during mid-gestation (100–200d). Samples of Longissimus dorsi muscle were collected from the offspring at 30d and 450d postnatal. Muscle fiber number was found to be decreased as a result of maternal protein restriction and persisted throughout the offspring’s life (p < 0.01). The collagen content was enhanced (p < 0.05) due to maternal protein restriction at 30d. MHC2X mRNA expression tended to be higher (p = 0.08) in RES 30d offspring, however, no difference (p > 0.05) was found among treatments at 450d. Taken together, our results suggest that maternal protein restriction during mid-gestation has major and persistent effects by reducing muscle fiber formation and may slightly increase collagen accumulation in the skeletal muscle of the offspring. Although maternal protein restriction may alter the muscle fiber metabolism by favoring the establishment of a predominant glycolytic metabolism, the postnatal environment may be a determinant factor that establishes the different proportion of muscle fiber types. Full article
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