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Antioxidants
Special Issues
Second Edition of Bioavailability and Bioactivity of Plant Antioxidants
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Second Edition of Bioavailability and Bioactivity of Plant Antioxidants

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2514

Special Issue Editors

Dr. Joanna Oracz

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Guest Editor
Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 2/22 Stefanowskiego Street, 90-537 Lodz, Poland
Interests: cocoa beans; acorns, roasting; phenolic compounds; methylxanthines; tocopherols; phytosterols; Maillard reaction products; melanoidins; antioxidant capacities; isolation and characterization of bioactive compounds; nutraceuticals
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Dorota Żyżelewicz

E-Mail Website
Guest Editor
Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 2/22 Stefanowskiego Street, 90-537 Lodz, Poland
Interests: cocoa beans; roasting; phenolic compounds; methylxanthines; tocopherols; phytosterols; Maillard reaction products; antioxidant capacities; isolation and characterization of bioactive compounds; nutraceuticals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are organizing a second edition of the Special Issue “Bioavailability and Bioactivity of Plant Antioxidants” in Antioxidants, which is an interdisciplinary, peer-reviewed open access journal for research into the science and technology of antioxidants.

Plant-derived antioxidants comprise a large group of chemical compounds including secondary plant metabolites (e.g., polyphenols, carotenoids, tocopherols, and coumarins) and substances formed in food during processing (e.g., Maillard reaction products). These compounds are widely distributed in fruits and vegetables as well as their derived products. Natural antioxidants have been gaining increasing interest due to the association between their consumption and the prevention of cardiovascular disease, cancer, neurodegenerative disorders, diabetes, and other illnesses. Many research studies on plant-derived antioxidants have shown that these compounds exhibit a wide range of biological effects, including anti-aging, anti-inflammatory, anti-atherosclerotic, and anticancer effects. The bioavailability and bioefficacy of plant-derived antioxidants, including polyphenols, carotenoids, and tocopherols, are dependent on their molecular structure, food matrix, occurrence of other substances, and their digestion pathways. Recent evidence suggests that knowledge of the pharmacokinetics and metabolism of bioactive compounds is crucial to understand their role and function in human health. Furthermore, interactions of these bioactive compounds with the gut microbiota may also influence their biological roles. However, the precise mechanisms of the action, effects, and bioavailability of plant antioxidants have still not yet been fully characterized.

This Special Issue is therefore seeking original research articles and reviews covering the elucidated effects of metabolism and pharmacokinetics on the efficacy of plant antioxidants and other potential health-promoting mechanisms. Also welcome are in vitro and in vivo studies on the plant-derived antioxidant–gut microbiota interactions as well as the bioavailability, bioaccessibility, and bioactivity (e.g., antioxidant and anti-inflammatory) of plant antioxidants.

Dr. Joanna Oracz
Prof. Dr. Dorota Żyżelewicz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural antioxidants
  • polyphenols
  • carotenoids
  • tocopherols and tocotrienols
  • Maillard reaction products
  • in vitro and in vivo antioxidant activity
  • mechanism of action of antioxidant compounds
  • bioaccessibility and bioavailability of antioxidant compounds
  • metabolism and pharmacokinetics of plant antioxidants
  • interaction of plant antioxidants with gut microbiota
  • microbial catabolites

Published Papers (2 papers)

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20 pages, 5960 KiB  
Article
Optimization of the Extraction Conditions of Polyphenols from Red Clover (Trifolium pratense L.) Flowers and Evaluation of the Antiradical Activity of the Resulting Extracts
by Beata Drużyńska, Jakub Łukasiewicz, Ewa Majewska and Rafał Wołosiak
Antioxidants 2024, 13(4), 414; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox13040414 - 28 Mar 2024
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Abstract
The purpose of this study was to analyze the effect of the type of extraction solution (water, different concentrations of ethanol), temperature and time on the polyphenol content and antioxidant properties of red clover extracts and the effect of the addition of selected [...] Read more.
The purpose of this study was to analyze the effect of the type of extraction solution (water, different concentrations of ethanol), temperature and time on the polyphenol content and antioxidant properties of red clover extracts and the effect of the addition of selected extracts on the antioxidant properties of enriched blackcurrant beverages. In both the extractions carried out under different conditions and in the enriched beverages, the content of selected polyphenols was determined by HPLC. This study confirmed the significant effect of the alcohol content of the extract, extraction time and temperature on the antioxidant properties of clover extracts. Ethanolic extracts had better antioxidant properties than aqueous extracts. The addition of ethanol extracts had a significant effect on the antioxidant properties of the fortified beverages. Increasing the temperature, time or ethanol content in the extracts mostly resulted in an increase in the total polyphenol content in the obtained extracts. Based on the analysis of the response surface, it was found that for the DPPH radical, the best activity was obtained by extraction for 20 min with a solution of approximately 65% at low temperatures. In the case of the ABTS radical, the best antiradical activity was obtained after extraction for 60 min at 80 °C with a solution of approximately 50% ethanol. It was also found that the use of a solution of approximately 60% ethanol after extraction for 60 min at 80 °C would provide an extract with high antiradical activity against both radicals. Full article
(This article belongs to the Special Issue Second Edition of Bioavailability and Bioactivity of Plant Antioxidants)
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21 pages, 819 KiB  
Article
Exploring the Antioxidant Potential of Blackberry and Raspberry Leaves: Phytochemical Analysis, Scavenging Activity, and In Vitro Polyphenol Bioaccessibility
by Iulia Varzaru, Alexandra Gabriela Oancea, Petru Alexandru Vlaicu, Mihaela Saracila and Arabela Elena Untea
Antioxidants 2023, 12(12), 2125; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox12122125 - 16 Dec 2023
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Abstract
The goal of this research was nutritional evaluation through the phytochemical analysis of blackberry and raspberry leaves, the screening of their biological activity (antioxidant capacity and inhibition of lipid peroxidation), and the investigation of the effect of in vitro gastrointestinal digestion (GID) of [...] Read more.
The goal of this research was nutritional evaluation through the phytochemical analysis of blackberry and raspberry leaves, the screening of their biological activity (antioxidant capacity and inhibition of lipid peroxidation), and the investigation of the effect of in vitro gastrointestinal digestion (GID) of blackberry and raspberry leaves on the bioaccessibility of polyphenol subclasses. The concentrations of the analyzed liposoluble antioxidants were higher (p < 0.05) in blackberry leaves compared to raspberry leaves, while a significant (p < 0.05) higher content of water-soluble antioxidants was registered in raspberry leaves (with a total polyphenol content of 26.2 mg GAE/g DW of which flavonoids accounted for 10.6 mg/g DW). Blackberry leaves had the highest antioxidant capacity inhibition of the superoxide radicals (O2•−), while raspberry leaves registered the highest inhibition of hydroxyl radicals (•OH), suggesting a high biological potency in scavenging-free radicals under in vitro systems. The maximum inhibition percentage of lipid peroxidation was obtained for blackberry leaves (24.86% compared to 4.37% in raspberry leaves), suggesting its potential to limit oxidative reactions. Simulated in vitro digestion showed that hydroxybenzoic acids registered the highest bioaccessibility index in the intestinal phase of both types of leaves, with gallic acid being one of the most bioaccessible phenolics. The outcomes of this investigation reveal that the most significant release of phenolic compounds from blackberry and raspberry leaves occurs either during or after the gastric phase. Knowledge about the bioaccessibility and stability of polyphenol compounds during digestion can provide significant insights into the bioavailability of these molecules and the possible effectiveness of plant metabolites for human health. Full article
(This article belongs to the Special Issue Second Edition of Bioavailability and Bioactivity of Plant Antioxidants)
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