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Antioxidants
Special Issues
Advances in Antioxidants & Immunoactives from Marine Algae
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Advances in Antioxidants & Immunoactives from Marine Algae

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 5056

Special Issue Editors

Dr. Christophe Brunet

E-Mail Website
Guest Editor
Stazione Zoologica Anton Dohrn, sede Molosiglio, via Acton 55, 80133 Naples, Italy
Interests: photosynthesis; microalgae; bioactive molecules; biotechnology
Special Issues, Collections and Topics in MDPI journals
Dr. Clementina Sansone

E-Mail Website
Guest Editor
Stazione Zoologica Anton Dohrn, Naples, Italy
Interests: marine biotechnology; drug discovery; cell biology; pharmaceuticals; nutraceuticals and cosmetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is a pleasure for us to invite you to contribute to this Special Issue of Antioxidants on “Advances in Antioxidants & Immunoactives from Marine Algae”. Authors interested in this topic are invited to submit original research papers or review articles covering the different aspects of the antioxidant and/or immunomodulatory properties of algal resources and their human or animal benefits. Algal immunoreactive compounds, i.e., compounds able to strengthen the body’s natural defenses and to boost the immune system are of great interest for the eco-friendly and sustainable development of new nutraceuticals, cosmeceuticals or feed products, based on (micro-)algal sources. Algae do generally contain a high content and diversity of known and less known bioactive compounds (e.g., carotenoids, phenolic compounds or vitamins), and some might be considered a factory for their synthesis. Contributions reporting bioactivity assessment of algal biomass or extracts are welcome, together with documented activities of some specific algal compounds. Reports on in vitro or in vivo description of immune-stimulatory activities of algal biomass/extracts in human or animals against not communicable and/or communicable pathologies are also greatly appreciated.

Dr. Christophe Brunet
Dr. Clementina Sansone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microalgae
  • macroalgae
  • vitamins
  • polyphenols
  • carotenoids
  • chemoprevention
  • antiviral
  • health promotion
  • nutraceuticals
  • immune system

Published Papers (2 papers)

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Research

19 pages, 7448 KiB  
Article
Elucidation of Antiviral and Antioxidant Potential of C-Phycocyanin against HIV-1 Infection through In Silico and In Vitro Approaches
by Pratiksha Jadaun, Chandrabhan Seniya, Sudhir Kumar Pal, Sanjit Kumar, Pramod Kumar, Vijay Nema, Smita S Kulkarni and Anupam Mukherjee
Antioxidants 2022, 11(10), 1942; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11101942 - 28 Sep 2022
Cited by 9 | Viewed by 2696
Abstract
Antiretroviral therapy is the single existing therapy for patients infected with HIV; however, it has drawbacks in terms of toxicity and resistance. Thus, there is a continuous need to explore safe and efficacious anti-retroviral agents. C-Phycocyanin (C-PC) is a phycobiliprotein, which has been [...] Read more.
Antiretroviral therapy is the single existing therapy for patients infected with HIV; however, it has drawbacks in terms of toxicity and resistance. Thus, there is a continuous need to explore safe and efficacious anti-retroviral agents. C-Phycocyanin (C-PC) is a phycobiliprotein, which has been known for various biological properties; however, its effect on HIV-1 replication needs revelation. This study aimed to identify the inhibitory effects of C-PC on HIV-1 using in vitro and in silico approaches and to assess its role in the generation of mitochondrial reactive oxygen species (ROS) during HIV-1 infection. In vitro anti-HIV-1 activity of C-PC was assessed on TZM-bl cells through luciferase gene assay against four different clades of HIV-1 strains in a dose-dependent manner. Results were confirmed in PBMCs, using the HIV-1 p24 antigen assay. Strong associations between C-PC and HIV-1 proteins were observed through in silico molecular simulation-based interactions, and the in vitro mechanistic study confirmed its target by inhibition of reverse transcriptase and protease enzymes. Additionally, the generation of mitochondrial ROS was detected by the MitoSOX and DCF-DA probe through confocal microscopy. Furthermore, our results confirmed that C-PC treatment notably subdued the fluorescence in the presence of the virus, thus reduction of ROS and the activation of caspase-3/7 in HIV-1-infected cells. Overall, our study suggests C-PC as a potent and broad in vitro antiviral and antioxidant agent against HIV-1 infection. Full article
(This article belongs to the Special Issue Advances in Antioxidants & Immunoactives from Marine Algae)
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16 pages, 1787 KiB  
Article
The Microalgal Diatoxanthin Inflects the Cytokine Storm in SARS-CoV-2 Stimulated ACE2 Overexpressing Lung Cells
by Clementina Sansone, Luigi Pistelli, Angelo Del Mondo, Luana Calabrone, Angelo Fontana, Douglas M. Noonan, Adriana Albini and Christophe Brunet
Antioxidants 2022, 11(8), 1515; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11081515 - 03 Aug 2022
Cited by 6 | Viewed by 1858
Abstract
Contact between SARS-CoV-2 and human lung cells involves the viral spike protein and the human angiotensin-converting enzyme 2 (ACE2) receptor on epithelial cells, the latter being strongly involved in the regulation of inflammation as well as blood pressure homeostasis. SARS-CoV-2 infection is characterized [...] Read more.
Contact between SARS-CoV-2 and human lung cells involves the viral spike protein and the human angiotensin-converting enzyme 2 (ACE2) receptor on epithelial cells, the latter being strongly involved in the regulation of inflammation as well as blood pressure homeostasis. SARS-CoV-2 infection is characterized by a strong inflammatory response defined as a “cytokine storm”. Among recent therapeutic approaches against SARS-CoV-2 targeting the dramatic inflammatory reaction, some natural products are promising. Diatoms are microalgae able to produce bioactive secondary metabolites, such as the xanthophyll diatoxanthin (Dt). The aim of this study is to demonstrate the anti-inflammatory effects of Dt on the A549-hACE2 lung cell line, exploring its interaction with the ACE2 receptor, as well as depicting its role in inhibiting a cytokine storm induced by the SARS-CoV-2 spike glycoprotein. Results showed that Dt enhanced the cell metabolism, e.g., the percent of metabolically active cells, as well as the ACE2 enzymatic activity. Moreover, Dt strongly affected the response of the SARS-CoV-2 spike glycoprotein-exposed A549-hACE2 cells in decreasing the interleukin-6 production and increasing the interleukin-10 release. Moreover, Dt upregulated genes encoding for the interferon pathway related to antiviral defense and enhanced proteins belonging to the innate immunity response. The potential interest of Dt as a new therapeutic agent in the treatment and/or prevention of the severe inflammatory syndrome related to SARS-CoV-2 infection is postulated. Full article
(This article belongs to the Special Issue Advances in Antioxidants & Immunoactives from Marine Algae)
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