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Antioxidants
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Antioxidant Capacity of Bioactive Plant Compounds for Therapeutic Purpose—2nd Edition
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Antioxidant Capacity of Bioactive Plant Compounds for Therapeutic Purpose—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 4144

Special Issue Editor

Dr. María Jesús Rodríguez-Yoldi

E-Mail Website
Guest Editor
Department of Pharmacology and Physiology, Legal and Forensic Medicine, Physiology Unit, Faculty of Veterinary Medicine, University of Zaragoza, 50013 Zaragoza, Spain
Interests: intestinal absorption of nutrients; sepsis status (LPS, cytokines and inflammation); plant extracts and olive oil (squalene) for therapeutic purposes; encapsulation of plant extracts to improve their bioavailability; antioxidant and anti-inflammatory properties of plant extracts; antioxidant and anti-inflammatory markers; studies (modulators, pathways and targets) of apoptosis, necroptosis and autophagy; cell culture; cancer (mainly colon cancer) and diseases related to oxidative stress (cardiovascular, osteoarthritis and cancer); chemotherapeutics (gold complexes)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plant extracts have been used since ancient times for therapeutic purposes. These extracts contain bioactive compounds such as polyphenols with great antioxidant activity, so they can be applied in the prevention or treatment of diseases related to oxidative stress such as cancer, osteoarthritis, or cardiovascular diseases. Likewise, these extracts can also come from agri-food and forestry residues, which until now have been discarded, being thrown into landfills and incinerators. Therefore, the bioactive compounds present in these extracts show promising potential to be used in food, nutraceutical, and biomedical applications, reducing this waste and facilitating the circular economy.

Dr. María Jesús Rodríguez-Yoldi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant extracts
  • bioactive compounds
  • polyphenols
  • stress oxidative diseases
  • waste
  • circular economy

Published Papers (4 papers)

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Research

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17 pages, 2341 KiB  
Article
Ginger Polyphenols Reverse Molecular Signature of Amygdala Neuroimmune Signaling and Modulate Microbiome in Male Rats with Neuropathic Pain: Evidence for Microbiota–Gut–Brain Axis
by Chwan-Li Shen, Julianna Maria Santos, Moamen M. Elmassry, Viren Bhakta, Zarek Driver, Guangchen Ji, Vadim Yakhnitsa, Takaki Kiritoshi, Jacob Lovett, Abdul Naji Hamood, Shengmin Sang and Volker Neugebauer
Antioxidants 2024, 13(5), 502; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox13050502 - 23 Apr 2024
Viewed by 541
Abstract
Emerging evidence shows that the gut microbiota plays an important role in neuropathic pain (NP) via the gut–brain axis. Male rats were divided into sham, spinal nerve ligation (SNL), SNL + 200 mg GEG/kg BW (GEG200), and SNL + 600 mg GEG/kg BW [...] Read more.
Emerging evidence shows that the gut microbiota plays an important role in neuropathic pain (NP) via the gut–brain axis. Male rats were divided into sham, spinal nerve ligation (SNL), SNL + 200 mg GEG/kg BW (GEG200), and SNL + 600 mg GEG/kg BW (GEG600) for 5 weeks. The dosages of 200 and 600 mg GEG/kg BW for rats correspond to 45 g and 135 g raw ginger for human daily consumption, respectively. Both GEG groups mitigated SNL-induced NP behavior. GEG-supplemented animals had a decreased abundance of Rikenella, Muribaculaceae, Clostridia UCG-014, Mucispirillum schaedleri, RF39, Acetatifactor, and Clostridia UCG-009, while they had an increased abundance of Flavonifactor, Hungatella, Anaerofustis stercorihominis, and Clostridium innocuum group. Relative to sham rats, Fos and Gadd45g genes were upregulated, while Igf1, Ccl2, Hadc2, Rtn4rl1, Nfkb2, Gpr84, Pik3cg, and Abcc8 genes were downregulated in SNL rats. Compared to the SNL group, the GEG200 group and GEG600 group had increases/decreases in 16 (10/6) genes and 11 (1/10) genes, respectively. GEG downregulated Fos and Gadd45g genes and upregulated Hdac2 genes in the amygdala. In summary, GEG alleviates NP by modulating the gut microbiome and reversing a molecular neuroimmune signature. Full article
(This article belongs to the Special Issue Antioxidant Capacity of Bioactive Plant Compounds for Therapeutic Purpose—2nd Edition)
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31 pages, 5559 KiB  
Article
Chemical Composition and Biological Properties of New Romanian Lavandula Species
by Ionuț Georgică Marchidan, Alina Ortan, Simona Marcu Spinu, Sorin Marius Avramescu, Ionela Avram, Radu Claudiu Fierascu and Narcisa Babeanu
Antioxidants 2023, 12(12), 2127; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox12122127 - 16 Dec 2023
Viewed by 1152
Abstract
The aims of the present study were to evaluate for the first time the chemical composition and antioxidant, antibacterial, antifungal and antiproliferative potentials of the Romanian George 90 lavender species, as well as parental species, L. angustifolia and L. latifolia. The L. [...] Read more.
The aims of the present study were to evaluate for the first time the chemical composition and antioxidant, antibacterial, antifungal and antiproliferative potentials of the Romanian George 90 lavender species, as well as parental species, L. angustifolia and L. latifolia. The L. angustifolia, L. latifolia and George 90 essential oils were analyzed by GC-MS/MS and the L. angustifolia, L. latifolia and George 90 hydroalcoholic extracts were analyzed by HPLC-DAD. The antioxidant, antibacterial, antifungal and antiproliferative assays revealed that all the investigated species showed significant activities. The results highlighted the chemical composition and the promising biological potentials of the L. angustifolia, L. latifolia and George 90 lavender species, validating their ethnomedicinal value, which offers potential applications as natural drugs. Full article
(This article belongs to the Special Issue Antioxidant Capacity of Bioactive Plant Compounds for Therapeutic Purpose—2nd Edition)
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Review

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19 pages, 709 KiB  
Review
Exploring the Antioxidative Effects of Ginger and Cinnamon: A Comprehensive Review of Evidence and Molecular Mechanisms Involved in Polycystic Ovary Syndrome (PCOS) and Other Oxidative Stress-Related Disorders
by Sladjana Novakovic, Vladimir Jakovljevic, Nikola Jovic, Kristina Andric, Milica Milinkovic, Teodora Anicic, Bozidar Pindovic, Elena Nikolaevna Kareva, Vladimir Petrovich Fisenko, Aleksandra Dimitrijevic and Jovana Joksimovic Jovic
Antioxidants 2024, 13(4), 392; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox13040392 - 25 Mar 2024
Viewed by 838
Abstract
Oxidative stress represents the pathophysiological basis for most disorders, including reproductive issues. Polycystic ovary syndrome (PCOS) is heterogeneous endocrine disorder of women characterized primarily by irregular menstrual cycles, hyper-androgenism, and ovulatory dysfunction. In the last decades, PCOS was recognized as a systemic silent [...] Read more.
Oxidative stress represents the pathophysiological basis for most disorders, including reproductive issues. Polycystic ovary syndrome (PCOS) is heterogeneous endocrine disorder of women characterized primarily by irregular menstrual cycles, hyper-androgenism, and ovulatory dysfunction. In the last decades, PCOS was recognized as a systemic silent inflammation and an oxidative disturbance-related disorder, exerting multifaceted symptoms, including metabolic. PCOS treatment should involve a personalized approach tailored to individual symptoms; however, the results are often unsatisfactory. Various supplementary treatments have been proposed to assist in the management and alleviation of PCOS symptoms. Cinnamon and ginger, known for millennia as herbs used in spices or traditional medicine for the treatment of various diseases, are of interest in this study. The aim of this study is to evaluate and investigate the effects of cinnamon and ginger in PCOS patients. Using relevant keywords we searched through PubMed/MEDLINE, Science Direct, Google Scholar and Web of science to find animal studies, pre-clinical, and clinical studies which were then reviewed for usage. Out of all of the reviewed studies a total of 65 studies were included in this review article. Cinnamon and ginger can affect hormonal status, lipid profile, obesity, and insulin resistance by mitigating oxidative stress and inflammation. Generally, based on current clinical evidence, it was revealed that supplementation with cinnamon or ginger had a useful impact in patients with PCOS. This review summarizes the antioxidative effects of ginger and cinnamon in PCOS treatment, highlighting their potential benefits in other oxidative stress-related pathologies. Full article
(This article belongs to the Special Issue Antioxidant Capacity of Bioactive Plant Compounds for Therapeutic Purpose—2nd Edition)
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20 pages, 4771 KiB  
Review
Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases
by Rosanna Avola, Alessandro Giuseppe Furnari, Adriana Carol Eleonora Graziano, Alessandra Russo and Venera Cardile
Antioxidants 2024, 13(2), 178; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox13020178 - 31 Jan 2024
Viewed by 1114
Abstract
Neuroinflammation, a pivotal factor in the pathogenesis of various brain disorders, including neurodegenerative diseases, has become a focal point for therapeutic exploration. This review highlights neuroinflammatory mechanisms that hallmark neurodegenerative diseases and the potential benefits of essential oils in counteracting neuroinflammation and oxidative [...] Read more.
Neuroinflammation, a pivotal factor in the pathogenesis of various brain disorders, including neurodegenerative diseases, has become a focal point for therapeutic exploration. This review highlights neuroinflammatory mechanisms that hallmark neurodegenerative diseases and the potential benefits of essential oils in counteracting neuroinflammation and oxidative stress, thereby offering a novel strategy for managing and mitigating the impact of various brain disorders. Essential oils, derived from aromatic plants, have emerged as versatile compounds with a myriad of health benefits. Essential oils exhibit robust antioxidant activity, serving as scavengers of free radicals and contributing to cellular defense against oxidative stress. Furthermore, essential oils showcase anti-inflammatory properties, modulating immune responses and mitigating inflammatory processes implicated in various chronic diseases. The intricate mechanisms by which essential oils and phytomolecules exert their anti-inflammatory and antioxidant effects were explored, shedding light on their multifaceted properties. Notably, we discussed their ability to modulate diverse pathways crucial in maintaining oxidative homeostasis and suppressing inflammatory responses, and their capacity to rescue cognitive deficits observed in preclinical models of neurotoxicity and neurodegenerative diseases. Full article
(This article belongs to the Special Issue Antioxidant Capacity of Bioactive Plant Compounds for Therapeutic Purpose—2nd Edition)
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