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Antioxidants
Special Issues
Reactive Oxygen Species (ROS) in Gastrointestinal Diseases—2nd Edition
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Reactive Oxygen Species (ROS) in Gastrointestinal Diseases—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 1804

Special Issue Editors

Prof. Dr. Young Do Jung

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Guest Editor
Department of Biochemistry, Chonnam National University Medical School, Hwasun 58128, Republic of Korea
Interests: cancer; signaling; transcription factor; gene regulation; ROS; antioxidants
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Yong Xia

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Guest Editor
Institute of Precision Medicine, Jining Medical University, Jining 272067, China
Interests: oxidative stress; gene regulation; molecular oncology; tumor microenvironment; pharmacological mechanism
Dr. Sen Lian

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
Interests: anticancer target; molecular mechanism; cell signaling pathway; gastrointestinal cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Shinan Li

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China
Interests: molecular oncology; ROS; transcription factor; gene regulation; tumor microenvironment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS) play a crucial role in developing various chronic and degenerative gastrointestinal diseases, such as cancer and digestive system disorders. ROS, including superoxide and hydrogen peroxide, can act as secondary messengers in intracellular signaling pathways during cancer cell progression and are associated with multiple signaling cascades that modulate cell proliferation, invasion, and angiogenesis.

For this Special Issue, we invite researchers to submit original research articles and review articles covering, but not limited to, the following topics:

  • Novel antioxidant molecules with a wide range of applications, including large molecular antioxidant compounds, such as polymers and macromolecular compounds. In particular, this includes their applications in clinical medicines, natural compounds, synthesized compounds, and other bioactive chemicals for gastrointestinal diseases.
  • Mechanisms underlying the action of antioxidant molecules, providing a foundation for developing new antioxidant drugs.
  • The role of ROS in the development of gastrointestinal diseases.

We welcome contributions from a wide range of fields, including medicinal chemistry, biochemistry, molecular oncology, nutrition, molecular biology, and more.

We look forward to receiving your contributions to this Special Issue.

Prof. Dr. Young Do Jung
Prof. Dr. Yong Xia
Dr. Sen Lian
Dr. Shinan Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reactive oxygen species (ROS)
  • gastrointestinal diseases
  • antioxidant molecules
  • intracellular signaling
  • cancer cell progression

Published Papers (2 papers)

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Research

21 pages, 4543 KiB  
Article
Sulforaphane Inhibits IL-1β-Induced IL-6 by Suppressing ROS Production, AP-1, and STAT3 in Colorectal Cancer HT-29 Cells
by Dhiraj Kumar Sah, Archana Arjunan, Seon Young Park, Bora Lee and Young Do Jung
Antioxidants 2024, 13(4), 406; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox13040406 - 28 Mar 2024
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Abstract
Colorectal cancer (CRC) stands as a major cause of cancer-related mortality globally, accounting for approximately 881,000 deaths each year. Traditional approaches such as chemotherapy and surgery have been the primary treatment modalities, yet the outcomes for patients with metastatic CRC are often unsatisfactory. [...] Read more.
Colorectal cancer (CRC) stands as a major cause of cancer-related mortality globally, accounting for approximately 881,000 deaths each year. Traditional approaches such as chemotherapy and surgery have been the primary treatment modalities, yet the outcomes for patients with metastatic CRC are often unsatisfactory. Recent research has focused on targeting the pathways involved in oxidative stress, inflammation, and metastasis to enhance the survival of CRC patients. Within this context, sulforaphane (SFN), a notable phytochemical found predominantly in cruciferous vegetables, has been recognized as a potential anticancer agent. However, the specific mechanisms through which SFN may exert its chemopreventive effects in CRC remain unclear. This study explores the impact of SFN on IL-1β-induced IL-6 activation and MAPK and AP-1 signaling in HT-29 cells. Our findings reveal that SFN treatment not only diminishes IL-1β-stimulated IL-6 expression but also reduces oxidative stress by curtailing reactive oxygen species (ROS) production. Furthermore, it hinders the proliferation and invasiveness of HT-29 cells through the modulation of MAPK/AP-1 and STAT3 signaling pathways. These results indicate that SFN mitigates IL-1β-induced IL-6 expression in CRC cells by attenuating ROS production and disrupting MAPK/AP-1 signaling. This suggests that SFN holds significant potential as a chemotherapeutic agent for both treating and preventing CRC. Full article
(This article belongs to the Special Issue Reactive Oxygen Species (ROS) in Gastrointestinal Diseases—2nd Edition)
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18 pages, 4483 KiB  
Article
Potential Phytotherapy of DSS-Induced Colitis: Ameliorating Reactive Oxygen Species-Mediated Necroptosis and Gut Dysbiosis with a New Crataegus pinnatifida Bunge Variety—Daehong
by Kang-In Lee, Yousang Jo, Heung Joo Yuk, Sun-Young Kim, Hyungjun Kim, Hye Jin Kim, Soo-Keol Hwang and Ki-Sun Park
Antioxidants 2024, 13(3), 340; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox13030340 - 12 Mar 2024
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Abstract
Developing new plant varieties plays a crucial role in competitiveness in the agricultural and food industries and enhancing food security. Daehong (DH) is a new variety of Crataegus pinnatifida Bunge (CP); however, its physiological functions and potential as a nutraceutical ingredient remain unknown. [...] Read more.
Developing new plant varieties plays a crucial role in competitiveness in the agricultural and food industries and enhancing food security. Daehong (DH) is a new variety of Crataegus pinnatifida Bunge (CP); however, its physiological functions and potential as a nutraceutical ingredient remain unknown. Here, the efficacy of DH on inflammatory bowel disease (IBD) was investigated using dextran sulfate sodium (DSS)-induced colitis mice, and its relative pharmacological effects were analyzed against CP. DH improved colitis-induced weight loss, colon shortening, and inflammatory responses and reduced intestinal permeability. The reactive oxygen species (ROS)-mediated necroptotic signal that triggers enterocyte cell death in DSS-induced colitis was effectively controlled by DH, attributed to epicatechin. DSS-induced gut dysbiosis was recovered into a healthy gut microbiome environment by DH, increasing beneficial bacteria, like Akkermansia muciniphila, and changing harmful bacteria, including Bacteroides vulgatus and Peptostreptococcaceae. DH shows potential as a dietary or pharmaceutical ingredient to promote gut health and to prevent and treat IBD. Full article
(This article belongs to the Special Issue Reactive Oxygen Species (ROS) in Gastrointestinal Diseases—2nd Edition)
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