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Antioxidants
Special Issues
Metal and Metalloid-Induced Oxidative Damage
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Metal and Metalloid-Induced Oxidative Damage

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: closed (15 January 2023) | Viewed by 7778

Special Issue Editor

Dr. Gustavo Rafael Mazzaron Barcelos

E-Mail Website
Guest Editor
Department of Biosciences, Institute for Health and Society, Federal University of São Paulo, Santos, Brazil
Interests: genomic instability; gene–environment interactions; human biomonitoring; epigenetics; environmental and occupational toxicology

Special Issue Information

Dear Colleagues,

There is a wide variation in concentrations of the biomarkers of exposure, effect, and susceptibility associated with exposure to toxic compounds, despite similar levels of exposure and this is hypothetically related gene interactions as in the process of kinetics and dynamics of these compounds, resulting in disturbances of redox status, apoptosis, cell death, alterations of epigenetic status, DNA-damage and cancer. However, very little is known about the gene-metals interactions and their mechanisms of toxicity, as well as underlying effects related to co-exposure to these toxic compounds.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the mechanisms underlying metals-induced disturbances on redox status, apoptosis, cell death and DNA-damage either in laboratory models (in vitro and in vivo) as in exposed individuals. We are particularly interested in articles describing epigenetic alterations concerning toxic metals-induced disturbances on these biomarkers. Biomonitoring studies related to exposed individuals are especially welcome.

Potential topics include, but are not limited to:

  • Recent developments on toxicology studies related to toxic metals compounds;
  • Mechanisms of toxicant-induced DNA-damage, disturbances of redox status and cell death;
  • New outcomes related to genetic variations such as polymorphisms and epigenetic events that can modulate the dynamics and kinetics of these compounds, and consequently, the toxicity induced by them.
  • Impact of toxic metals on gene expression (genomic and proteomic assays) and their roles on biological systems;
  • New biomarkers for exposure assessment;
  • Studies about gene-toxicants, as well as gene-gene interactions in subjects exposed to toxic metals.

Dr. Gustavo Rafael Mazzaron Barcelos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • DNA instability
  • epigenetics
  • gene-environment interactions
  • inorganic toxicants
  • oxidative damage

Published Papers (3 papers)

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Research

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24 pages, 1969 KiB  
Article
Causation of Oxidative Stress and Defense Response of a Yeast Cell Model after Treatment with Orthodontic Alloys Consisting of Metal Ions
by Vito Kovač, Matic Bergant, Janez Ščančar, Jasmina Primožič, Polona Jamnik and Borut Poljšak
Antioxidants 2022, 11(1), 63; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11010063 - 28 Dec 2021
Cited by 6 | Viewed by 2695
Abstract
Misaligned teeth have a tremendous impact on oral and dental health, and the most efficient method of correcting the problem is orthodontic treatment with orthodontic appliances. The study was conducted to investigate the metal composition of selected orthodontic alloys, the release of metal [...] Read more.
Misaligned teeth have a tremendous impact on oral and dental health, and the most efficient method of correcting the problem is orthodontic treatment with orthodontic appliances. The study was conducted to investigate the metal composition of selected orthodontic alloys, the release of metal ions, and the oxidative consequences that the metal ions may cause in the cell. Different sets of archwires, stainless steel brackets, and molar bands were incubated in artificial saliva for 90 days. The composition of each orthodontic material and quantification of the concentration of metal ions released were evaluated. Metal ion mixtures were prepared to determine the occurrence of oxidative stress, antioxidant enzyme defense system, and oxidative damage to proteins. The beta titanium alloy released the fewest metal ions and did not cause oxidative stress or protein damage. The metal ions from stainless steel and the cobalt-chromium alloy can cause oxidative stress and protein damage only at high concentrations. All metal ions from orthodontic alloys alter the activity of antioxidant enzymes in some way. The determined amounts of metal ions released from orthodontic appliances in a simulated oral environment are still below the maximum tolerated dose, and the concentrations of released metal ions are not capable of inducing oxidative stress, although some changes in antioxidant enzyme activity were observed at these concentrations. Full article
(This article belongs to the Special Issue Metal and Metalloid-Induced Oxidative Damage)
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Review

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36 pages, 12924 KiB  
Review
Recent Overview of Potent Antioxidant Activity of Coordination Compounds
by Hany M. Abd El-Lateef, Tarek El‐Dabea, Mai M. Khalaf and Ahmed M. Abu-Dief
Antioxidants 2023, 12(2), 213; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox12020213 - 17 Jan 2023
Cited by 20 | Viewed by 2318
Abstract
During recent decades, the complexation of organic ligands toward several metal ions of s-p and d-block has been applied as a plan to enhance its antioxidant performance. Due to their wide range of beneficial impacts, coordination compounds are widely used in industries, specifically [...] Read more.
During recent decades, the complexation of organic ligands toward several metal ions of s-p and d-block has been applied as a plan to enhance its antioxidant performance. Due to their wide range of beneficial impacts, coordination compounds are widely used in industries, specifically in the medicinal and pharmaceutical fields. The activity is generally improved by chelation consequently knowing that the characteristics of both ligands and metals can lead to the development of greatly active compounds. Chelation compounds are a substitute for using the traditional synthetic antioxidants, because metal chelates present benefits, including a variety in geometry, oxidation states, and coordination number, that assist and favor the redox methods associated with antioxidant action. As well as understanding the best studied anti-oxidative assets of these compounds, coordination compounds are involved in the free radical scavenging process and protecting human organisms from the opposing effects of these radicals. The antioxidant ability can be assessed by various interrelated systems. The methodological modification offers the most knowledge on the antioxidant property of metal chelates. Colorimetric techniques are the most used, though electron paramagnetic resonance (EPR) is an alternative for metallic compounds, since color does not affect the results. Information about systems, with their benefits, and restrictions, permits a dependable valuation of the antioxidant performance of coordination compounds, as well as assisting application in various states wherever antioxidant drugs are required, such as in food protection, appropriate good-packaged foods, dietary supplements, and others. Because of the new exhaustive analysis of organic ligands, it has become a separate field of research in chemistry. The present investigation will be respected for providing a foundation for the antioxidant properties of organic ligands, future tests on organic ligands, and building high-quality antioxidative compounds. Full article
(This article belongs to the Special Issue Metal and Metalloid-Induced Oxidative Damage)
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16 pages, 946 KiB  
Review
The Role of Lead and Cadmium in Gynecological Malignancies
by Gabriela Furtak, Mateusz Kozłowski, Sebastian Kwiatkowski and Aneta Cymbaluk-Płoska
Antioxidants 2022, 11(12), 2468; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11122468 - 15 Dec 2022
Cited by 2 | Viewed by 2088
Abstract
Lead and cadmium are non-essential and toxic heavy metals. Their presence and elevated levels can lead to many pathologies. They disrupt the antioxidant properties of many enzymes, consume the resources of antioxidant cells, and thus participate in the generation of oxidative stress, which [...] Read more.
Lead and cadmium are non-essential and toxic heavy metals. Their presence and elevated levels can lead to many pathologies. They disrupt the antioxidant properties of many enzymes, consume the resources of antioxidant cells, and thus participate in the generation of oxidative stress, which may result in DNA damage. In addition, they have been found to be carcinogenic through their genotoxic properties. They have been shown to be present in various types of cancer, including cancer of the female reproductive system. Both metals have been recognized as metalloestrogens, which are important in hormone-related cancers. Participation in the oncogenesis of ovarian, endometrial and cervical cancer was analysed in detail, using the available research in this field. We emphasize their role as potential biomarkers in cancer risk and diagnosis as well as advancement of gynaecological malignancies. Full article
(This article belongs to the Special Issue Metal and Metalloid-Induced Oxidative Damage)
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