The Role of Reactive Oxygen Species in Innate Immunity
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 2574
Special Issue Editors
Interests: macrophages, reactive oxygen species, mitochondria, redox signaling, infection
Special Issue Information
Dear Colleagues,
The importance of ROS for innate immunity has been demonstrated by many studies and their functions comprise direct and indirect antimicrobial activity. The most prominent direct antimicrobial function is the ROS-mediated inactivation and elimination of foreign organisms like bacteria, viruses and parasites. Indirect functions of ROS include the broad range of redox-regulated immune processes, such as modulation of pro- and anti-inflammatory signaling pathways, induction of inflammasomes and chemotaxis. The spectrum of ROS-related functions in innate immunity is as complex as the various innate immune cell types and their interplay. Phagocytes, including macrophages or neutrophils are the mainly investigated immune cell types concerning ROS-related processes, but also in other leukocytes, such as mast cells or natural killer cells, ROS play important roles for innate immune defense.
In this Special Issue, we want to invite researchers to contribute both original research and review articles. Studies that provide strong mechanistic insights regarding the precise roles of ROS in innate immune cells are still scarce. Therefore, we particularly welcome articles that unravel new molecular aspects of redox-regulated functions during innate immune responses. Articles that offer novel methodological approaches for detailed analysis of ROS production in innate immune cells are also highly appreciated.
Dr. Marc Herb
Prof. Dr. Roberto Giovannoni
Guest Editors
Manuscript Submission Information
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Keywords
- reactive oxygen species
- NADPH oxidase (Nox)
- mitochondria
- innate immunity
- redox signaling
- infection
- inflammation
