Recent Advances in Traumatic Brain Injury Using Large Animal Models

Dear Colleagues,

Traumatic brain injury is a paramount global health concern and presents a substantial economic burden worldwide. Detecting mild traumatic brain injury (mTBI), which constitutes the majority of TBI cases, poses challenges as brain abnormalities are not easily detected using conventional diagnostic imaging, despite cognitive dysfunction and prolonged impairment. From a physiological perspective, acute primary brain injury is believed to stem from tissue deformation caused by the inertial movement of the brain following rapid head rotation. In order to comprehend the mechanisms and pathophysiology of mTBI, large animal models are a valuable tool for studying the biomechanics of TBI as neuroanatomical characteristics, such as white and grey matter distinctions in addition to well-circumscribed gyri and sulci, appropriate the effects of mechanical loading on the brain.

This Special Issue will serve to address a preclinical platform for developing and evaluating diagnostic as well as prognostic tools and interventions through the presentation of original research articles, reviews, and rapid short communication papers focusing on "Recent Advances in Traumatic Brain Injury Using Large Animal Models". The primary target audience for this Special Issue includes researchers employing an integrated biomechanics approach that incorporates large animal models, cell and tissue experiments, human studies, and the subsequent translation of these findings into preclinical therapeutic trials aimed at mitigating and preventing brain injuries.

Prof. Dr. Susan Margulies
Dr. Anna Oeur
Guest Editors

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• traumatic brain injury
• large animal models
• biomarkers
• experimental
• neurotrauma
• neurological disorders
• biomechanics