Osteoarthritis: Molecular Pathways and Novel Therapeutic Strategies

Dear Colleagues,

Osteoarthritis (OA) is a prevalent and degenerative joint disorder characterized by the progressive deterioration of joint cartilage and the surrounding structures. It is the most common form of arthritis and often affects weight-bearing joints such as the knees, hips. Osteoarthritis (OA) exhibits a spectrum of clinical phenotypes, reflecting the heterogeneous nature of this prevalent joint disorder: (1) Chronic Pain Phenotype (Emphasizes central mechanisms, such as central sensitization; Characterized by persistent pain, potentially influencing treatment strategies); (2) Inflammatory Phenotype (Marked by elevated levels of inflammatory biomarkers); (3) Metabolic Syndrome Phenotype (Exhibits a high prevalence of obesity, diabetes, and metabolic disturbances); (4) Bone and Cartilage Metabolism Phenotype (Involves alterations in local tissue metabolism); (5) Mechanical Overload Phenotype (Primarily characterized by varus malalignment and medial compartment disease); (6) Minimal Joint Disease Phenotype (Characterized by minor clinical symptoms with slow progression). These distinct phenotypes, characterized by varying patterns of symptoms, disease progression, and treatment responses, play a pivotal role in tailoring effective interventions for individuals affected by OA. Recognizing and categorizing individuals based on these phenotypes holds promise for refining therapeutic strategies and improving overall outcomes in the diverse landscape of osteoarthritis. This Special Issue, will include a selection of original articles and reviews aimed at expanding our awareness and new insights into molecular and cellular mechanisms, key signaling pathways and novel therapeutic strategies in the treatment of osteoarthritis disease.

Dr. Antonia Patruno
Dr. Teresa Paolucci
Dr. Mirko Pesce
Dr. Andrea Pantalone
Guest Editors

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• osteoarthritis
• cartilage
• pain
• orthopedics
• rehabilitation