Anti-inflammatory Activity of Plant Polyphenols 3.0

Dear Colleagues,

We are pleased to announce the launch of a third volume of the Special Issue “Anti-Inflammatory Activity of Plant Polyphenols”. Inflammation is the first bodily response to infection or injury and is critical for both innate and adaptive immunity. It can be considered part of the complex biological response of vascular tissues to harmful stimuli such as pathogens, damaged cells, and irritants. Uncontrolled inflammation often results in the development of chronic diseases such as gastritis, arthritis, autoimmune disorders, degenerative joint diseases, rheumatism, atherosclerosis, diabetes, and even cancer. The inflammatory process is characterized by the migration of immune cells from blood vessels to the site of inflammation, with a massive release of pro-inflammatory mediators including cytokines, chemokines, prostaglandins, leukotrienes, and oxidative agents.

New strategies that are able to interfere with these mechanisms by preventing prolonged inflammation will greatly benefit numerous areas. In this respect, the plant kingdom has developed a multitude of secondary metabolites, many of which are recognized as useful tools for the maintenance of human health. Several botanicals from edible or medicinal plants are consumed worldwide for health purposes as different types of products including herbal medicinal products, plant food supplements, and functional foods. The purpose of this Special Issue of Biomedicines is to collect new findings on the anti-inflammatory activities of plant polyphenols as individual compounds or as ingredients of extracts, focusing mostly on their effects on the inhibition of pro-inflammatory mediators and their mechanisms of action. Both in vitro and in vivo studies are welcome.

Dr. Enrico Sangiovanni
Dr. Stefano Piazza
Guest Editors

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• botanicals
• plant polyphenols
• anti-inflammatory
• cytokines
• transcription factors
• chemokines
• pro-inflammatory mediators
• eicosanoids
• secondary metabolites