Stem Cell Signaling 2.0

Dear Colleagues,

While stem cell research has mainly focused on preclinical studies aimed at the development of stem cell-based cell therapy, many fundamental questions regarding the cellular and molecular features of stem cells remain. Thanks to technical advances in culture and differentiation of a number of different stem cells, the self-renewal and differentiation potential—which define the properties of stem cells—have been explored through their epigenetic regulation, transcriptional networks, and signaling pathways. Furthermore, recent advances in various interesting stem cell models, such as cellular reprogramming, naïve pluripotent stem cells, and organoids, have extended understanding of the underlying mechanisms behind how stem cells maintain stemness and commit fate determination.

This Special Issue of Biomedicines focuses on recent advances in understanding the underlying mechanisms of pluripotency, self-renewal, lineage differentiation, cellular reprogramming, regeneration, and related diseases. The goal is to promote fundamental knowledge in this exciting field in order to provide the inclusive basic knowledge necessary for regenerative medicine.

We encourage authors to submit original research and review articles that focus on the various biological features and underlying mechanisms of both pluripotent stem cells and somatic stem cells. Potential topics include but are not limited to:

• The mechanism of pluripotency maintenance;
• The mechanism of cellular reprogramming or cellular plasticity;
• The mechanism of lineage determination or differentiation;
• The mechanism of stemness (or self-renewal) maintenance or regeneration;
• The mechanism of stem cell aging;
• The mechanism of embryo development;
• Conversion between naïve and primed pluripotency.

Dr. Hyuk-Jin Cha
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• stem cells
• signaling
• development
• reprogramming
• differentiation
• self-renewal
• regeneration
• cellular plasticity