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Biomimetics
Special Issues
Fabrication of Polymeric Hydrogels
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Fabrication of Polymeric Hydrogels

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetics of Materials and Structures".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 3952

Special Issue Editors

Dr. Gargi Joshi

E-Mail Website
Guest Editor
B CUBE–Center for Molecular Bioengineering, Technische Universität Dresden, Dresden, Germany
Interests: biopolymers; liquid crystals; hydrogels; structure-function; diffraction
Special Issues, Collections and Topics in MDPI journals
Dr. Maninder Singh

E-Mail Website
Guest Editor
Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, Japan
Interests: nanomaterials; polymers; hydrogels; thermoelectrics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hydrogels, contrary to the popular belief, are not only used in biomedical and tissue engineering applications but are also widely applied in electronics and magnetic device fabrication technology. They feature as structural support, design templates, or majorly as functional matrices. As a three-dimensional network, they can have a myriad of functionalities depending on the final structure and the chemistry of incorporated polymers.

From the materials point of view, hydrogels with dynamic adaptability and responsiveness to some sort of stimuli are in much demand. This Special Issue aims to involve authors and their work towards both, the fundamental understanding of hydrogel design as well as the specific application-based design. We seek latest developments in blends of polymers, inorganic materials and biopolymers including the composition-structure-function for publication in this issue.

We hope this issue will motivate researchers to submit their high-quality results and engage in a fruitful review process. 

Best wishes.

Dr. Gargi Joshi
Dr. Maninder Singh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomimetics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymers
  • nanocomposites
  • biomaterials
  • anisotropy
  • structure-function

Published Papers (3 papers)

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Research

14 pages, 4610 KiB  
Article
Porous Polylactide Microparticles as Effective Fillers for Hydrogels
by Yuriy D. Zagoskin, Yana E. Sergeeva, Yuliya S. Fomina, Daniil V. Sukhinov, Sergey N. Malakhov, Egor O. Osidak, Elena A. Khramtsova, Pavel M. Gotovtsev, Sergei N. Chvalun and Timofei E. Grigoriev
Biomimetics 2023, 8(8), 565; https://0-doi-org.brum.beds.ac.uk/10.3390/biomimetics8080565 - 23 Nov 2023
Viewed by 1266
Abstract
High-strength composite hydrogels based on collagen or chitosan–genipin were obtained via mixing using highly porous polylactide (PLA) microparticles with diameters of 50–75 µm and porosity values of over 98%. The elastic modulus of hydrogels depended on the filler concentration. The modulus increased from [...] Read more.
High-strength composite hydrogels based on collagen or chitosan–genipin were obtained via mixing using highly porous polylactide (PLA) microparticles with diameters of 50–75 µm and porosity values of over 98%. The elastic modulus of hydrogels depended on the filler concentration. The modulus increased from 80 kPa to 400–600 kPa at a concentration of porous particles of 12–15 wt.% and up to 1.8 MPa at a filling of 20–25 wt.% for collagen hydrogels. The elastic modulus of the chitosan–genipin hydrogel increases from 75 kPa to 900 kPa at a fraction of particles of 20 wt.%. These elastic modulus values cover a range of strength properties from connective tissue to cartilage tissue. It is important to note that the increase in strength in this case is accompanied by a decrease in the density of the material, that is, an increase in porosity. PLA particles were loaded with C-phycocyanin and showed an advanced release profile up to 48 h. Thus, composite hydrogels mimic the structure, biomechanics and release of biomolecules in the tissues of a living organism. Full article
(This article belongs to the Special Issue Fabrication of Polymeric Hydrogels)
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18 pages, 5303 KiB  
Article
Hydrogels Based on Polyacrylamide and Calcium Alginate: Thermodynamic Compatibility of Interpenetrating Networks, Mechanical, and Electrical Properties
by Alexander P. Safronov, Nadezhda M. Kurilova, Lidiya V. Adamova, Tatyana F. Shklyar, Felix A. Blyakhman and Andrey Yu. Zubarev
Biomimetics 2023, 8(3), 279; https://0-doi-org.brum.beds.ac.uk/10.3390/biomimetics8030279 - 28 Jun 2023
Cited by 1 | Viewed by 1053
Abstract
The synthesis and physicochemical properties of hydrogels with interpenetrated physical and chemical networks were considered in relation to their prospective application as biomimetic materials in biomedicine and bioengineering. The study was focused on combined hydrogels based on natural polysaccharide—calcium alginate (CaAlg) and a [...] Read more.
The synthesis and physicochemical properties of hydrogels with interpenetrated physical and chemical networks were considered in relation to their prospective application as biomimetic materials in biomedicine and bioengineering. The study was focused on combined hydrogels based on natural polysaccharide—calcium alginate (CaAlg) and a synthetic polymer–polyacrylamide (PAAm). The series of hydrogels with varying proportions among alginate and polyacrylamide have been synthesized, and their water uptake has been characterized depending on their composition. The equilibrium swelling and re-swelling in water after drying were considered. The compatibility of alginate and polyacrylamide in the combined blend was studied by the thermodynamic approach. It showed a controversial combination of negative enthalpy of mixing among PAAm and CaAlg with positive Gibbs energy of mixing. Mechanical and electrical properties of the combined gels with double networking were studied as relevant for their prospective use as scaffolds for tissue regeneration and working bodies in actuators. The storage modulus and the loss modulus were determined in the oscillatory compression mode as a function of proportions among natural and synthetic polymers. Both moduli substantially increased with the content of CaAlg and PAAm. The electrical (Donnan) potential of hydrogels was measured using the capillary electrode technique. The Donnan potential was negative at all compositions of hydrogels, and its absolute values increased with the content of CaAlg and PAAm. Full article
(This article belongs to the Special Issue Fabrication of Polymeric Hydrogels)
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19 pages, 4137 KiB  
Article
Manufacture of Bilayered Composite Hydrogels with Strong, Elastic, and Tough Properties for Osteochondral Repair Applications
by Hui Yao, Congcong Wang, Yuchen Zhang, Ying Wan and Qing Min
Biomimetics 2023, 8(2), 203; https://0-doi-org.brum.beds.ac.uk/10.3390/biomimetics8020203 - 16 May 2023
Cited by 2 | Viewed by 1297
Abstract
Layered composite hydrogels have been considered attractive materials for use in osteochondral repair and regeneration. These hydrogel materials should be mechanically strong, elastic, and tough besides fulfilling some basic requirements such as biocompatibility and biodegradability. A novel type of bilayered composite hydrogel with [...] Read more.
Layered composite hydrogels have been considered attractive materials for use in osteochondral repair and regeneration. These hydrogel materials should be mechanically strong, elastic, and tough besides fulfilling some basic requirements such as biocompatibility and biodegradability. A novel type of bilayered composite hydrogel with multi-network structures and well-defined injectability was thus developed for osteochondral tissue engineering using chitosan (CH), hyaluronic acid (HA), silk fibroin (SF), CH nanoparticles (NPs), and amino-functionalized mesoporous bioglass (ABG) NPs. CH was combined with HA and CH NPs to build the chondral phase of the bilayered hydrogel, and CH, SF, and ABG NPs were used together to construct the subchondral phase of the bilayer hydrogel. Rheological measurements showed that the optimally achieved gels assigned to the chondral and subchondral layers had their elastic moduli of around 6.5 and 9.9 kPa, respectively, with elastic modulus/viscous modulus ratios higher than 36, indicating that they behaved like strong gels. Compressive measurements further demonstrated that the bilayered hydrogel with an optimally formulated composition had strong, elastic, and tough characteristics. Cell culture revealed that the bilayered hydrogel had the capacity to support the in-growth of chondrocytes in the chondral phase and osteoblasts in the subchondral phase. Results suggest that the bilayered composite hydrogel can act as an injective biomaterial for osteochondral repair applications. Full article
(This article belongs to the Special Issue Fabrication of Polymeric Hydrogels)
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