Dear Colleagues,

Over the past few decades, new -omic approaches, such as Genome-Wide Association Studies (GWAS), Whole-Exome Sequencing (WES), transcriptomics and proteomics, metabolomics, etc., have allowed researchers to identify novel causative genetic variants and biological signaling pathways that contribute to the susceptibility and severity of several skin disorders. Therefore, Next-Generation Sequencing (NGS) analyses, in combination with bioinformatics pipelines, enabled researchers to employ a more comprehensive approach to unravelling the complex aetiology of skin diseases, such as atopic dermatitis, psoriasis, pyoderma gangrenosum and hidradenitis suppurativa, thus, allowing for the translation of the -omic findings to diagnosis and patient follow-up.

Despite this, the pathophysiology of these autoimmune/autoinflammatory skin diseases has not been fully elucidated and a clear genotype–phenotype correlation is still to be improved.

The aim of this Special Issue is to inspire the community by exploring new approaches and perspectives on the mechanisms underlying autoimmune/autoinflammatory skin diseases and potential therapeutic targets for personalized medicine.

We encourage researchers in the field of -omics applied to autoimmune/autoinflammatory skin diseases to contribute with original articles, reviews and communications on the pathophysiology of these skin diseases, needing more data to be fully understood in favor of patient-tailored treatment.

Prof. Dr. Angelo Valerio Marzano
Prof. Dr. Sergio Crovella
Dr. Chiara Moltrasio
Guest Editors

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• autoimmune/autoinflammatory skin diseases
• omics
• bioinformatics
• pathogenesis
• tailored medicine