Mitochondrial Proteins: From Import and Biogenesis to Complex Functional Network
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Proteins".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 3311
Special Issue Editor
Interests: mitochondria; protein quality control; Lon protease; oxidative stress; metabolism; cardiotoxicity; myocardial infarction; mtDNA; cardiovascular disease; cancer
Special Issue Information
Dear Colleagues,
We know that only ~1% of mitochondrial proteins are encoded by mtDNA, and the rest of ~99% are encoded by nuclear DNA and imported into mitochondria through a regulated process, which is critical for optimal cellular function. In addition, mitochondria are not only energy-producing factories but also play vital roles in other subsidiary functions, such as calcium homeostasis, cellular signaling, regulation of heme, steroid, nucleotide, fatty acid synthesis, and apoptosis, to name a few. Therefore, understanding the role of mitochondrial proteins and their contribution to mitochondrial function is of utmost importance as most human diseases are associated with some form of mitochondrial dysfunction. Furthermore, such proteins involve various roles ranging from mitochondrial import and biogenesis to a complex functional network. Therefore, we believe that studying and understanding these mitochondrial proteins is of utmost importance in developing novel therapeutic strategies and tools to target them in human diseases. Thus, I welcome you to contribute to this Special Issue with original or review articles dealing with such mitochondrial proteins to take a step forward in targeting mitochondria in human diseases.
Dr. Venkatesh Sundararajan
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondrial proteins
- import
- biogenesis
- metabolism
- functional network
- oxidative stress
- small molecules
- mitochondrial protein quality control
- mitophagy