New Insights into Neuroimmunology

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 1516

Special Issue Editor


E-Mail Website
Guest Editor
Institute for Neuroimmunology and Multiple Sclerosis Research, Göttingen, Germany
Interests: blood-brain barrier; immune cells; multiple sclerosis; experimental autoimmune encephalomyelitis; two-photon microscopy; B cells; T cells; dendritic cells; macrophages; astrocytes; microglia; oligodendrocytes; neurons; central nervous system; autoimmune disease; ion channels; calcium signaling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For a long time, the central nervous system (CNS) was described as an immune-privileged organ devoid of contact with the immune compartment in homeostatic conditions. This paradigm was in part explained by the presence of CNS barriers. Nowadays, we know that peripheral immune cells patrol the CNS in both patients and healthy individuals. During disease, extensive intricate interactions occur between leukocytes and CNS resident cells. Further understanding these direct and indirect communications between the cells could help, on one hand, prevent deleterious neuroinflammation, while, on the other hand, could help promote repair mechanisms and restore homeostasis.

The aim of this Special Issue of the journal Biomolecules is to highlight new or recently described neuroimmune cell interactions and biological processes involved during states of health and neurological diseases. Original research manuscripts, reviews and communications are invited.

Dr. Marc André Lécuyer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuroimmunology (in health and disease)
  • multiple sclerosis (MS)
  • experimental autoimmune encephalomyelitis (EAE)
  • acute disseminated encephalomyelitis (ADEM)
  • neuromyelitis optica spectrum disorders (NMOSD)
  • transverse myelitis
  • anti-NMDA receptor encephalitis (NMDAR encephalitis)
  • paraneoplastic autoimmune diseases
  • neurodegenerative diseases with immunological components
  • Parkinson’s disease
  • Alzheimer’s disease
  • neuroinfections

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 9406 KiB  
Article
CXCL10 Is Associated with Increased Cerebrospinal Fluid Immune Cell Infiltration and Disease Duration in Multiple Sclerosis
by Stephanie N. Blandford, Neva J. Fudge and Craig S. Moore
Biomolecules 2023, 13(8), 1204; https://0-doi-org.brum.beds.ac.uk/10.3390/biom13081204 - 01 Aug 2023
Cited by 1 | Viewed by 1296
Abstract
Background: Cerebrospinal fluid (CSF) is an important sampling site for putative biomarkers and contains immune cells. CXCL10 is a multiple sclerosis (MS)-relevant chemokine that is present in the injured central nervous system and recruits CXCR3+ immune cells toward injured tissues. Objective: Perform a [...] Read more.
Background: Cerebrospinal fluid (CSF) is an important sampling site for putative biomarkers and contains immune cells. CXCL10 is a multiple sclerosis (MS)-relevant chemokine that is present in the injured central nervous system and recruits CXCR3+ immune cells toward injured tissues. Objective: Perform a comprehensive evaluation to determine a potential relationship between CXCL10 and various immune cell subsets in the CNS of MS and control cases. Methods: In MS and control cases, CXCL10 was measured in the CSF and plasma by ELISA. Immune cells within both the CSF and peripheral blood were quantified by flow cytometry. Results: Compared to non-inflammatory neurological disease (NIND) cases, MS cases had significantly higher CXCL10 in CSF (p = 0.021); CXCL10 was also correlated with total cell numbers in CSF (p = 0.04) and T cell infiltrates (CD3+, p = 0.01; CD4+, p = 0.01; CD8+, p = 0.02); expression of CXCR3 on peripheral immune cell subsets was not associated with CSF CXCL10. Conclusions: Elevated levels of CXCL10 in the CSF of MS cases are associated with increased T cells but appear to be independent of peripheral CXCR3 expression. These results support the importance of elevated CXCL10 in MS and suggest the presence of an alternative mechanism of CXCL10 outside of solely influencing immune cell trafficking. Full article
(This article belongs to the Special Issue New Insights into Neuroimmunology)
Show Figures

Figure 1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: To be determined
Authors: Marc André Lécuyer; et al.
Affiliation: Institute for Neuroimmunology and Multiple Sclerosis Research, Göttingen, Germany

Back to TopTop