Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.3
5.5
Journals
Biomolecules
Special Issues
Endocrine and Immune Metabolism Mechanisms in Endometrium-Related Diseases
share announcement

Endocrine and Immune Metabolism Mechanisms in Endometrium-Related Diseases

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Reproduction".

Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 5764

Special Issue Editors

Dr. Mingqing Li

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Fudan University, Shanghai 200011, China
Interests: productive biology; reproductive immunology; autophagy; endometriosis; miscarriage; decidua; trophoblast
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Giuseppe Benagiano

E-Mail Website
Guest Editor
Department of Maternal and Child Health, Gynaecology and Urology, Sapienza, University of Rome, Rome, Italy
Interests: reproductive endocrinology; adenomyosis; contraception; endometriosis; placental bed
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As the inner lining of the uterus, the endometrium contains stromal cells, epithelial cells, and immune cells (i.e., NK cell, macrophage, T cell), and undergoes periodic changes in growth, differentiation, and degeneration under ovarian hormones. Endometrium plays an indispensable role in embryo implantation, the constitution of foetal-maternal interface, and the establishment and maintenance of pregnancy. In pathophysiological conditions, abnormality or disorder in the endometrium may lead to endometrium-related diseases, such as infertility, recurrent implantation failure, spontaneous abortion, endometriosis, adenomyosis, intrauterine adhesions, endometrium hyperplasia and even endometrial carcinoma. The immune metabolism consists of metabolic programs of different cell subsets that are distinctly associated with immunological function.

This Topic will attempt to take a closer look at research investigating the uterine endometrium microenvironment, endocrine metabolism and immune metabolism features that may benefit patients being treated for these conditions.

Potential topics include but are not limited to the following:

  1. Single-cell transcriptomics, proteomics and metabolome profiles of the endometrium and decidua;
  2. Interrogate hormones, metabolite, and immune regulation for mechanisms underlying endometrial receptivity, decidualization, and endometrium-related diseases;
  3. Molecular mechanisms of senescence, autophagy, oxidative stress, and proptosis in endometrium-related diseases;
  4. Novel targets of endocrine and immune metabolism for endometrium-related diseases;
  5. Novel immunomodulatory therapies to endometrium-related diseases.

The aim of this Special Issue is to solicit original research and review articles that illustrate or comment on the mechanisms underlying the pathogenesis of endometrium-related diseases, with a focus on the endocrine and immune metabolic regulation of cells, which could support the development of therapeutic strategies.

Dr. Mingqing Li
Prof. Dr. Giuseppe Benagiano

Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oestrogen
  • progesterone
  • NK cell
  • macrophage
  • endometrium
  • decidua
  • metabolism
  • autophagy
  • senescence
  • infertility
  • recurrent implantation failure
  • spontaneous abortion
  • endometriosis
  • adenomyosis
  • endometrial carcinoma

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

18 pages, 5859 KiB  
Article
Integrating Transcriptomic and ChIP-Seq Reveals Important Regulatory Regions Modulating Gene Expression in Myometrium during Implantation in Pigs
by Weiwei Wang, Caiqin Cao, Botao Zhang, Feiyu Wang, Dadong Deng, Jianhua Cao, Hua Li and Mei Yu
Biomolecules 2023, 13(1), 45; https://0-doi-org.brum.beds.ac.uk/10.3390/biom13010045 - 26 Dec 2022
Cited by 3 | Viewed by 1395
Abstract
The myometrium is the outer layer of the uterus. Its contraction and steroidogenic activities are required for embryo implantation. However, the molecular mechanisms underlying its functions remain unknown in pigs. The myometrium includes the inner circular muscle (CM) and the outer longitudinal muscle [...] Read more.
The myometrium is the outer layer of the uterus. Its contraction and steroidogenic activities are required for embryo implantation. However, the molecular mechanisms underlying its functions remain unknown in pigs. The myometrium includes the inner circular muscle (CM) and the outer longitudinal muscle (LM) layers. In this study, we collected the CM and LM samples from the mesometrial side (named M) of the uterus on days 12 (pre-implantation stage) and 15 (implantation stage) of pregnancy and day 15 of the estrous cycle. The transcriptomic results revealed distinct differences between the uterine CM and LM layers in early pregnancy: the genes expressed in the LM layer were mainly related to contraction pathways, whereas the transcriptional signatures in the CM layer on day 15 of pregnancy were primarily involved in the immune response processes. Subsequent comparisons in the CM layer between pregnant and cyclic gilts show that the transcriptional signatures of the CM layer are implantation-dependent. Next, we investigated the genome-wide profiling of histone H3 lysine 27 acetylation (H3K27ac) and histone H3 lysine 4 trimethylation (H3K4me3) in pig uterine CM and LM layers. The genomic regions that had transcriptional activity and were associated with the expression of genes in the two layers were characterized. Taken together, the regulatory regions identified in the study may contribute to modulating the gene expression in pig uterine CM and LM layers during implantation. Full article
(This article belongs to the Special Issue Endocrine and Immune Metabolism Mechanisms in Endometrium-Related Diseases)
►▼ Show Figures

Figure 1

16 pages, 3331 KiB  
Article
Excess Heme Promotes the Migration and Infiltration of Macrophages in Endometrial Hyperplasia Complicated with Abnormal Uterine Bleeding
by Lu-Yu Ruan, Zhen-Zhen Lai, Jia-Wei Shi, Hui-Li Yang, Jiang-Feng Ye, Feng Xie, Xue-Min Qiu, Xiao-Yong Zhu and Ming-Qing Li
Biomolecules 2022, 12(6), 849; https://0-doi-org.brum.beds.ac.uk/10.3390/biom12060849 - 19 Jun 2022
Cited by 2 | Viewed by 1991
Abstract
In patients, endometrial hyperplasia (EH) is often accompanied by abnormal uterine bleeding (AUB), which is prone to release large amounts of heme. However, the role of excess heme in the migration and infiltration of immune cells in EH complicated by AUB remains unknown. [...] Read more.
In patients, endometrial hyperplasia (EH) is often accompanied by abnormal uterine bleeding (AUB), which is prone to release large amounts of heme. However, the role of excess heme in the migration and infiltration of immune cells in EH complicated by AUB remains unknown. In this study, 45 patients with AUB were divided into three groups: a proliferative phase group (n = 15), a secretory phase group (n = 15) and EH (n = 15). We observed that immune cell subpopulations were significantly different among the three groups, as demonstrated by flow cytometry analysis. Of note, there was a higher infiltration of total immune cells and macrophages in the endometrium of patients with EH. Heme up-regulated the expression of heme oxygenase-1 (HO-1) and nuclear factor erythroid-2-related factor 2 (Nrf2) in endometrial epithelial cells (EECs) in vitro, as well as chemokine (e.g., CCL2, CCL3, CCL5, CXCL8) levels. Additionally, stimulation with heme led to the increased recruitment of THP-1 cells in an indirect EEC-THP-1 co-culture unit. These data suggest that sustained and excessive heme in patients with AUB may recruit macrophages by increasing the levels of several chemokines, contributing to the accumulation and infiltration of macrophages in the endometrium of EH patients, and the key molecules of heme metabolism, HO-1 and Nrf2, are also involved in this regulatory process. Full article
(This article belongs to the Special Issue Endocrine and Immune Metabolism Mechanisms in Endometrium-Related Diseases)
►▼ Show Figures

Figure 1

Review

Jump to: Research

15 pages, 889 KiB  
Review
An Appraisal of the Tissue Injury and Repair (TIAR) Theory on the Pathogenesis of Endometriosis and Adenomyosis
by Marwan Habiba, Giuseppe Benagiano and Sun-Wei Guo
Biomolecules 2023, 13(6), 975; https://0-doi-org.brum.beds.ac.uk/10.3390/biom13060975 - 11 Jun 2023
Cited by 4 | Viewed by 1543
Abstract
As understanding their pathogenesis remains elusive, both endometriosis and adenomyosis are often referred to as “enigmatic diseases”. The uncertainty and heightened interest are reflected in the range of expressed views and opinions. There is a sense of urgency because of the entailed patient [...] Read more.
As understanding their pathogenesis remains elusive, both endometriosis and adenomyosis are often referred to as “enigmatic diseases”. The uncertainty and heightened interest are reflected in the range of expressed views and opinions. There is a sense of urgency because of the entailed patient suffering. The plethora of opinions calls for a critical analysis of proposed theories, both old and new. A series of papers published since 2009 proposed that both endometriosis and adenomyosis originate from the same aberrations occurring within the uterus. This came to be recognized as the tissue injury and repair theory, and the newly coined term “archimetrosis” posits that the two diseases share the same origin. While the theory opens an interesting channel for exploration, its claim as a unifying theory necessitates a critical appraisal. We, thus, undertook this review of the theory and analyzed its underpinnings based on a comprehensive review of the literature. Our appraisal indicates that the theory is open to a range of criticisms. Chief among these is the need for confirmatory evidence of features of abnormal uterine contractility and the lack of data addressing the question of causality. In addition, the theory has, as yet, no supporting epidemiological evidence, which is a major weakness. The theory suffers as it is not open to the test of falsifiability, and it lacks the ability to make useful predictions. It has not addressed the questions, such as why only a small percentage of women develop adenomyosis or endometriosis, given the ubiquity of uterine peristalsis. On the other hand, the triggers and prevention of hyper- or dys-peristalsis become critical to a theory of causation. We conclude that additional supportive evidence is required for the theory to be accepted. Full article
(This article belongs to the Special Issue Endocrine and Immune Metabolism Mechanisms in Endometrium-Related Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop