Dear Colleagues,

Synthetic DNA nanostructures, assembled from a few to hundreds of orthogonal oligonucleotides, have proven to be chemically addressable and highly programmable for building nanoscale platforms or devices. A wealth of evidence now demonstrates the potential of DNA nanotechnology in nanosensing applications. DNA nanostructures can interact with proteins, indigenous DNA and RNA, gold nanoparticles, quantum dots, DNAzymes, aptamers, and ions, among other molecules, and dynamically reconfigure to give out a reportable signal. DNA-based nanosystems also exemplify signal transduction from organic to inorganic complexes, signal amplification, and in vitro and in vivo biocompatibility. Last, but not least, synthetic DNA is amenable to storage under dried or hydrated conditions, a property that has expanded the diverse scenarios in which it can be transported and used. To that end, they are poised to form the basis of smarter diagnostic and biosensing tools that are modular, rapid, and possess several properties desired for advancing biomedicine.

For this Special Issue, we invite you to submit original research and review articles with a focus on the applications of DNA nanotechnology in biosensing and bioimaging. We welcome research that leverages the versatility of DNA nanotechnology as stand-alone nanosensors or as components that are coupled with physical phenomena such as resonance energy transfer, biological machines such as CRISPR-Cas, or sophisticated engineering in the form of advanced microscopy for biosensing/imaging purposes. DNA nanotechnology also encompasses non-canonical nucleic acids such as peptide nucleic acid and locked nucleic acid, which are emerging as robust alternatives to overcome degradation, and hence are of great interest. Review articles should describe the state of research in the area, the challenges that need to be addressed, and a perspective on the future of the field. We look forward to your contributions.

Dr. Divita Mathur
Dr. Igor Medintz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Nanomaterials
• DNA origami
• Microscopy
• FRET
• Fluorescence
• Imaging
• Spectroscopy
• CRISPR
• Nanoparticles
• Signal amplification