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Biosensors
Special Issues
Bioinspired and Biobased Materials for Biosensor Applications
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Bioinspired and Biobased Materials for Biosensor Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 9427

Special Issue Editor

Prof. Dr. Hua Li

E-Mail Website
Guest Editor
School of Mechanical & Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
Interests: modeling of smart hydrogels for bioMMS applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to share new developments in the growing field of bioinspired and biobased materials, especially for biosensor applications, as well as to understand new challenges that are being faced in these fields of research. Biosensors play a critical role in the detection and analysis of biomacromolecules such as proteins, lipid bilayers, and nucleic acids, which are often involved in a complex process in general. In order to address the relevant issues, we probably not only need to learn from nature for the development of bioinspired materials, but we also to learn from different sciences for the development of biobased materials in a multidisciplinary way. This Special Issue thus focuses on the latest research and development of bioinspired and biobased materials for biosensor applications, at all scales and from experiment to theory modeling. These include papers dealing with theoretical analyses and laboratory and field studies. Of course, contributions that demonstrate potential for practical feasibility are particularly welcome.

Prof. Li Hua
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Interactive bioinspired and biobased materials
  • Autonomous bioinspired and biobased materials
  • Stimuli-responsive bioinspired and biobased materials (photochromic, thermochromic, pH-sensitive, etc.)
  • Functional bioinspired and biobased materials

Published Papers (2 papers)

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Research

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15 pages, 4056 KiB  
Article
A Facile and Scalable Hydrogel Patterning Method for Microfluidic 3D Cell Culture and Spheroid-in-Gel Culture Array
by Chengxun Su, Yon Jin Chuah, Hong Boon Ong, Hui Min Tay, Rinkoo Dalan and Han Wei Hou
Biosensors 2021, 11(12), 509; https://0-doi-org.brum.beds.ac.uk/10.3390/bios11120509 - 10 Dec 2021
Cited by 16 | Viewed by 4686
Abstract
Incorporation of extracellular matrix (ECM) and hydrogel in microfluidic 3D cell culture platforms is important to create a physiological microenvironment for cell morphogenesis and to establish 3D co-culture models by hydrogel compartmentalization. Here, we describe a simple and scalable ECM patterning method for [...] Read more.
Incorporation of extracellular matrix (ECM) and hydrogel in microfluidic 3D cell culture platforms is important to create a physiological microenvironment for cell morphogenesis and to establish 3D co-culture models by hydrogel compartmentalization. Here, we describe a simple and scalable ECM patterning method for microfluidic cell cultures by achieving hydrogel confinement due to the geometrical expansion of channel heights (stepped height features) and capillary burst valve (CBV) effects. We first demonstrate a sequential “pillar-free” hydrogel patterning to form adjacent hydrogel lanes in enclosed microfluidic devices, which can be further multiplexed with one to two stepped height features. Next, we developed a novel “spheroid-in-gel” culture device that integrates (1) an on-chip hanging drop spheroid culture and (2) a single “press-on” hydrogel confinement step for rapid ECM patterning in an open-channel microarray format. The initial formation of breast cancer (MCF-7) spheroids was achieved by hanging a drop culture on a patterned polydimethylsiloxane (PDMS) substrate. Single spheroids were then directly encapsulated on-chip in individual hydrogel islands at the same positions, thus, eliminating any manual spheroid handling and transferring steps. As a proof-of-concept to perform a spheroid co-culture, endothelial cell layer (HUVEC) was formed surrounding the spheroid-containing ECM region for drug testing studies. Overall, this developed stepped height-based hydrogel patterning method is simple to use in either enclosed microchannels or open surfaces and can be readily adapted for in-gel cultures of larger 3D cellular spheroids or microtissues. Full article
(This article belongs to the Special Issue Bioinspired and Biobased Materials for Biosensor Applications)
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Review

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38 pages, 5209 KiB  
Review
Artificial Biomimetic Electrochemical Assemblies
by Tanja Zidarič, Matjaž Finšgar, Uroš Maver and Tina Maver
Biosensors 2022, 12(1), 44; https://0-doi-org.brum.beds.ac.uk/10.3390/bios12010044 - 15 Jan 2022
Cited by 11 | Viewed by 4017
Abstract
Rapid, selective, and cost-effective detection and determination of clinically relevant biomolecule analytes for a better understanding of biological and physiological functions are becoming increasingly prominent. In this regard, biosensors represent a powerful tool to meet these requirements. Recent decades have seen biosensors gaining [...] Read more.
Rapid, selective, and cost-effective detection and determination of clinically relevant biomolecule analytes for a better understanding of biological and physiological functions are becoming increasingly prominent. In this regard, biosensors represent a powerful tool to meet these requirements. Recent decades have seen biosensors gaining popularity due to their ability to design sensor platforms that are selective to determine target analytes. Naturally generated receptor units have a high affinity for their targets, which provides the selectivity of a device. However, such receptors are subject to instability under harsh environmental conditions and have consequently low durability. By applying principles of supramolecular chemistry, molecularly imprinted polymers (MIPs) can successfully replace natural receptors to circumvent these shortcomings. This review summarizes the recent achievements and analytical applications of electrosynthesized MIPs, in particular, for the detection of protein-based biomarkers. The scope of this review also includes the background behind electrochemical readouts and the origin of the gate effect in MIP-based biosensors. Full article
(This article belongs to the Special Issue Bioinspired and Biobased Materials for Biosensor Applications)
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