Special Issue "Lab-on-a-Chip Devices and Biosensors to Model Biological Barriers"

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Prof. Dr. András Dér
E-Mail Website
Guest Editor
Institute of Biophysics, Biological Research Centre, Temesvari krt 62, H-6726 Szeged, Hungary
Interests: integrated optics; electric properties of proteins and cells; lab-on-a-chip devices for photonic and biotechnological applications
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Mária A. Deli
E-Mail Website
Guest Editor
Institute of Biophysics, Biological Research Centre, Temesvari krt 62, H-6726 Szeged, Hungary
Interests: cell culture, organoid and lab-on-a-chip models of different biological barriers; human corneal, respiratory and gut epithelial cell models; protection of the biological barriers in pathologies; natural compounds as barrier-protecting agents; targeted nanoparticles for drug delivery across biological barriers; co-culture models of the blood–brain barrier; blood–brain barrier changes in Alzheimer’s and Parkinson’s diseases
Special Issues, Collections and Topics in MDPI journals
Dr. András Kincses
E-Mail Website
Guest Editor
Institute of Biophysics, Biological Research Centre, 6726 Szeged, Hungary
Interests: lab-on-a-chip technologies
Dr. Fruzsina Walter
E-Mail Website
Guest Editor
Institute of Biophysics, Biological Research Centre, Temesvari krt 62, H-6726 Szeged, Hungary
Interests: biological barriers, brain pathologies, drug delivery, permeability studies, organoid and lab-on-a-chip devices; animal and human vascular endothelial cell culture models; co-culture models of the blood–brain barrier; protection of the biological barriers in pathologies; natural compounds as barrier-protecting agents; surface glycocalyx, surface potential measurements

Special Issue Information

Dear Colleagues,

The importance of integrated biochips for studying biological barriers in vitro has been increased in the last decade. With the possibility of the coculturing of multiple cell types and to integrate spheroids and organoids, these lab-on-a-chip devices offer effective ways to understand physiological functions, transport mechanisms, drug delivery and pathologies. Biological barriers include the skin, cornea, respiratory and gastrointestinal epithelial barriers, which are the first to come in contact with the outside environment. In the body, endothelial and epithelial cells form barriers in the testis, placenta and in the brain (blood–brain barrier, choroid plexus, blood–retina barrier). These protect the specific organ systems from outside damage and maintain ionic and nutritional homeostasis within the tissue. Integrated microelectronic biochips provide a complex hardware for multicellular barrier culture modelling, including several crucial parameters needed for effective translational studies. With the newly emerging concept of human stem cell-derived models and organoids, the field has never been more complex. This Special Issue provides a platform to feature novel developments on the miniaturized microfluidic biochip device family, integrating all types of measurements. This includes barrier integrity measurements, morphology characterizations, physiology and pathology investigations, protection in diseases, novel ways of drug targeting, and gene and protein expression studies.

Prof. Dr. András Dér
Prof. Dr. Mária A. Deli
Dr. András Kincses
Dr. Fruzsina Walter
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lab-on-a-chip devices
  • microfluidics
  • microelectronics
  • endothelial and epithelial barriers
  • brain barriers
  • gastrointestinal barriers
  • respiratory barriers
  • skin barrier
  • cell culture, organoid and chip models
  • drug transport in chip models
  • biological barriers and pathological changes in chip devices
  • protection of biological barriers in diseases

Published Papers

This special issue is now open for submission.
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