Dear Colleagues,

Several enzymatic bioelectronic devices have been developed as end-user and time-saving analytical tools to detect many analytes for food, clinical, and environmental applications. Among the big ‘family’ of enzymatic bioelectronic devices, we can certainly include biosensors, biofuel cells, sensing/actuators devices, and lab-on-chip. Enzymes were historically the first molecular recognition elements included in biosensors and continue to be the basis for a significant number of publications in this field. Starting from the very first examples by Clark, Guilbault, and Montalvo, electrochemical transducers combined with enzymes as biochemical components have now became the largest category of biosensors for food, clinical, and environmental sensing.

Recently, all previous research about enzyme-based bioelectronics has been integrated with breakdown achievements on soft wearable/implantable bioelectronics. In particular, enzyme-based bioelectronics, built on diverse biocatalytic reactions, offers distinct advantages and represents a centerpiece of wearable biodevices. Such wearable/implantable bioelectronic devices predominately rely on oxidoreductase enzymes and have already demonstrated considerable promise for on-body applications ranging from highly selective noninvasive biomarker monitoring to epidermal energy harvesting. These systems can thus greatly increase the analytical capability of wearable/implantable devices from the ubiquitous monitoring of mobility and vital signs, toward little to noninvasive analysis of important chemical biomarkers.

This Special Issue, devoted to wearable/implantable enzymatic bioelectronic devices, aims to focus on the most recent advances in the development of wearable/implantable bioelectronic devices from the ubiquitous monitoring of mobility and vital signs, toward little to noninvasive analysis of important chemical biomarkers by using redox enzymes.

Prof. Gabriele Favero
Dr. Paolo Bollella
Guest Editors

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• Enzyme biosensors
• Enzyme fuel cells
• Sensing/actuators devices
• Lab-on-chip
• Enzyme immobilization
• Wearable bioelectronics
• Implantable bioelectronics